3LZB
| EGFR kinase domain complexed with an imidazo[2,1-b]thiazole inhibitor | Descriptor: | Epidermal growth factor receptor, N-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamide | Authors: | Swinger, K.K. | Deposit date: | 2010-03-01 | Release date: | 2011-03-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases. Bioorg.Med.Chem.Lett., 20, 2010
|
|
8RN8
| Influenza B polymerase pseudo-symmetrical apo-dimer (FluPol(E)|FluPol(S)) | Descriptor: | MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ... | Authors: | Arragain, B, Cusack, S. | Deposit date: | 2024-01-09 | Release date: | 2024-09-11 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase. Nat Commun, 15, 2024
|
|
8RN1
| Influenza B polymerase, monomeric encapsidase with 5' cRNA hook bound | Descriptor: | 5' cRNA hook (1-12), Polymerase acidic protein, Polymerase basic protein 2, ... | Authors: | Arragain, B, Cusack, S. | Deposit date: | 2024-01-09 | Release date: | 2024-09-11 | Method: | ELECTRON MICROSCOPY (3.64 Å) | Cite: | Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase. Nat Commun, 15, 2024
|
|
8RN2
| Monomeric apo-influenza B polymerase, encapsidase conformation | Descriptor: | Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit | Authors: | Arragain, B, Cusack, S. | Deposit date: | 2024-01-09 | Release date: | 2024-09-11 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase. Nat Commun, 15, 2024
|
|
8RNA
| Influenza B polymerase apo-trimer | Descriptor: | Acidic leucine-rich nuclear phosphoprotein 32 family member A, Polymerase acidic protein, Polymerase basic protein 2, ... | Authors: | Arragain, B, Cusack, S. | Deposit date: | 2024-01-09 | Release date: | 2024-09-11 | Method: | ELECTRON MICROSCOPY (3.57 Å) | Cite: | Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase. Nat Commun, 15, 2024
|
|
8RN3
| |
8RN7
| |
8RNB
| |
8RNC
| Influenza B polymerase, replication complex, an asymmetric polymerase dimer bound to human ANP32A (from "Influenza B polymerase apo-trimer" | Local refinement) | Descriptor: | Acidic leucine-rich nuclear phosphoprotein 32 family member A, Polymerase acidic protein, Polymerase basic protein 2, ... | Authors: | Arragain, B, Cusack, S. | Deposit date: | 2024-01-09 | Release date: | 2024-09-11 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase. Nat Commun, 15, 2024
|
|
8RN4
| |
8RN6
| |
8RN9
| |
8RN5
| |
6AGX
| |
5IB3
| Crystal structure of HLA-B*27:05 complexed with the self-peptide pVIPR and Copper | Descriptor: | Beta-2-microglobulin, COPPER (II) ION, GLYCEROL, ... | Authors: | Janke, R, Ballaschk, M, Schmieder, P, Uchanska-Ziegler, B, Ziegler, A, Loll, B. | Deposit date: | 2016-02-22 | Release date: | 2017-02-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Metal-triggered conformational reorientation of a self-peptide bound to a disease-associated HLA-B*27 subtype. J.Biol.Chem., 2019
|
|
6PVR
| Influenza B M2 Proton Channel in the Closed State - SSNMR Structure at pH 7.5 | Descriptor: | BM2 protein | Authors: | Mandala, V.S, Loftis, A.R, Shcherbakov, A.S, Pentelute, B.L, Hong, M. | Deposit date: | 2019-07-21 | Release date: | 2020-02-05 | Last modified: | 2024-05-01 | Method: | SOLID-STATE NMR | Cite: | Atomic structures of closed and open influenza B M2 proton channel reveal the conduction mechanism. Nat.Struct.Mol.Biol., 27, 2020
|
|
1CT9
| CRYSTAL STRUCTURE OF ASPARAGINE SYNTHETASE B FROM ESCHERICHIA COLI | Descriptor: | ADENOSINE MONOPHOSPHATE, ASPARAGINE SYNTHETASE B, CHLORIDE ION, ... | Authors: | Larsen, T.M, Boehlein, S.K, Schuster, S.M, Richards, N.G.J, Thoden, J.B, Holden, H.M, Rayment, I. | Deposit date: | 1999-08-20 | Release date: | 1999-12-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product. Biochemistry, 38, 1999
|
|
8GPZ
| Crystal structure of BRD4 bromodomain 1 (BD1) in complex with C239-0012 | Descriptor: | 3-methyl-6-(4-methylpiperidin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine, Bromodomain-containing protein 4, FORMIC ACID, ... | Authors: | Park, T.H, Lee, B.I. | Deposit date: | 2022-08-27 | Release date: | 2023-01-18 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.528 Å) | Cite: | Crystal structure of [1,2,4]triazolo[4,3-b]pyridazine derivatives as BRD4 bromodomain inhibitors and structure-activity relationship study. Sci Rep, 13, 2023
|
|
8GQ0
| Crystal structure of BRD4 bromodomain 1 (BD1) in complex with STL233497 | Descriptor: | Bromodomain-containing protein 4, FORMIC ACID, GLYCEROL, ... | Authors: | Park, T.H, Lee, B.I. | Deposit date: | 2022-08-27 | Release date: | 2023-01-18 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Crystal structure of [1,2,4]triazolo[4,3-b]pyridazine derivatives as BRD4 bromodomain inhibitors and structure-activity relationship study. Sci Rep, 13, 2023
|
|
7OEW
| |
1CIT
| DNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B | Descriptor: | DNA (5'-D(*CP*CP*GP*AP*AP*AP*AP*GP*GP*TP*CP*AP*TP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*AP*TP*GP*AP*CP*CP*TP*TP*TP*TP*CP*GP*G)-3'), PROTEIN (ORPHAN NUCLEAR RECEPTOR NGFI-B), ... | Authors: | Meinke, G, Sigler, P.B. | Deposit date: | 1999-04-05 | Release date: | 1999-05-03 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | DNA-binding mechanism of the monomeric orphan nuclear receptor NGFI-B. Nat.Struct.Biol., 6, 1999
|
|
6YGH
| Duck hepatitis B virus capsid | Descriptor: | Capsid protein | Authors: | Makbul, C, Bottcher, B. | Deposit date: | 2020-03-27 | Release date: | 2020-09-02 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability. Elife, 9, 2020
|
|
6YGI
| |
6Z9M
| Pseudoatomic model of the pre-fusion conformation of glycoprotein B of Herpes simplex virus 1 | Descriptor: | Envelope glycoprotein B | Authors: | Vollmer, B, Prazak, V, Vasishtan, D, Jefferys, E.E, Hernandez-Duran, A, Vallbracht, M, Klupp, B, Mettenleiter, T.C, Backovic, M, Rey, F.A, Topf, M, Gruenewald, K. | Deposit date: | 2020-06-04 | Release date: | 2020-10-07 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (9.1 Å) | Cite: | The prefusion structure of herpes simplex virus glycoprotein B. Sci Adv, 6, 2020
|
|
8U2D
| Bruton's tyrosine kinase in complex with N-[(2R)-1-[(3R)-3-(methylcarbamoyl)-1H,2H,3H,4H,9H-pyrido[3,4-b]indol-2-yl]-3-(3-methylphenyl)-1-oxopropan-2-yl]-1H-indazole-5-carboxamide | Descriptor: | (3R)-2-[N-(1H-indazole-5-carbonyl)-3-methyl-D-phenylalanyl]-N-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide, 1,2-ETHANEDIOL, CHLORIDE ION, ... | Authors: | Gajewski, S, Clifton, M.C. | Deposit date: | 2023-09-05 | Release date: | 2024-01-31 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton's Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies. J.Med.Chem., 67, 2024
|
|