7AVQ

Crystal structure of haspin in complex with disubstituted imidazo[1,2- b]pyridazine inhibitor (compound 12)

Summary for 7AVQ

• Entry DOI: 10.2210/pdb7avq/pdb
• Descriptor: Serine/threonine-protein kinase haspin, (2~{R})-2-[[3-(2~{H}-indazol-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol, SODIUM ION, ... (6 entities in total)
• Functional Keywords: kinase, haspin, gsg2, inhibitor, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 41359.20

Authors

Chaikuad, A.,Bonnet, P.,Routier, S.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-11-05, release date: 2020-11-18, Last modification date: 2024-01-31)

• Primary citation: Elie, J.,Feizbakhsh, O.,Desban, N.,Josselin, B.,Baratte, B.,Bescond, A.,Duez, J.,Fant, X.,Bach, S.,Marie, D.,Place, M.,Ben Salah, S.,Chartier, A.,Berteina-Raboin, S.,Chaikuad, A.,Knapp, S.,Carles, F.,Bonnet, P.,Buron, F.,Routier, S.,Ruchaud, S.; Design of new disubstituted imidazo[1,2- b ]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation.; J Enzyme Inhib Med Chem, 35:1840-1853, 2020; PubMed: 33040634; DOI: 10.1080/14756366.2020.1825408

Experimental method

X-RAY DIFFRACTION (1.65 Å)