8YTL

Human PPAR alpha ligand binding domain in complex with a 1H-pyrazolo[3,4-b]pyridine-derived compound

This is a non-PDB format compatible entry.

Summary for 8YTL

• Entry DOI: 10.2210/pdb8ytl/pdb
• Related: 8YT6
• Descriptor: Peroxisome proliferator-activated receptor alpha, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, S-1,2-PROPANEDIOL, ... (5 entities in total)
• Functional Keywords: agonist, complex, nuclear receptor, transcription
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 33678.28

Authors

Tachibana, K.,Morie, T.,Fukuda, S.,Yuzuriha, T.,Ishimoto, K.,Nunomura, K.,Lin, B.,Miyachi, H.,Oki, H.,Kawahara, K.,Meguro, K.,Nakagawa, S.,Tsujikawa, K.,Akai, S.,Doi, T.,Yoshida, T. (deposition date: 2024-03-26, release date: 2025-04-02)

• Primary citation: Tachibana, K.,Morie, T.,Fukuda, S.,Yuzuriha, T.,Ishimoto, K.,Nunomura, K.,Lin, B.,Miyachi, H.,Oki, H.,Kawahara, K.,Meguro, K.,Nakagawa, S.,Tsujikawa, K.,Akai, S.,Doi, T.,Yoshida, T.; Structural evolution of 1H-pyrazolo[3,4-b]pyridine-derived PPARalpha activators as leads for nonalcoholic steatohepatitis; To Be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)