1EJ1
| COCRYSTAL STRUCTURE OF THE MESSENGER RNA 5' CAP-BINDING PROTEIN (EIF4E) BOUND TO 7-METHYL-GDP | Descriptor: | 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E | Authors: | Marcotrigiano, J, Gingras, A.-C, Sonenberg, N, Burley, S.K. | Deposit date: | 2000-02-29 | Release date: | 2000-03-15 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP. Cell(Cambridge,Mass.), 89, 1997
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1EJ4
| COCRYSTAL STRUCTURE OF EIF4E/4E-BP1 PEPTIDE | Descriptor: | 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, EUKARYOTIC INITIATION FACTOR 4E, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E BINDING PROTEIN 1 | Authors: | Marcotrigiano, J, Gingras, A.-C, Sonenberg, N, Burley, S.K. | Deposit date: | 2000-02-28 | Release date: | 2000-03-15 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G. Mol.Cell, 3, 1999
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1EJH
| EIF4E/EIF4G PEPTIDE/7-METHYL-GDP | Descriptor: | 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, EUKARYOTIC INITIATION FACTOR 4E, EUKARYOTIC INITIATION FACTOR 4GII | Authors: | Marcotrigiano, J, Gingras, A.-C, Sonenberg, N, Burley, S.K. | Deposit date: | 2000-03-02 | Release date: | 2000-03-10 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G. Mol.Cell, 3, 1999
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5J5Y
| Translation initiation factor 4E in complex with m2(7,2'O)GppCCl2ppG mRNA 5' cap analog | Descriptor: | 2-amino-9-{5-O-[(R)-{[(S)-{dichloro[(R)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-2-O-methyl-beta-D-ribofuranosyl}-7-methyl-9H-purin-7-ium-6-olate, Eukaryotic translation initiation factor 4E, GLYCEROL | Authors: | Warminski, M, Nowak, E, Rydzik, A.M, Kowalska, J, Jemielity, J, Nowotny, M. | Deposit date: | 2016-04-04 | Release date: | 2017-05-10 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation. Nucleic Acids Res., 45, 2017
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7KCJ
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5J5O
| Translation initiation factor 4E in complex with m7GppppG mRNA 5' cap analog | Descriptor: | 5'-O-[(R)-hydroxy{[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]-7-methylguanosine, Eukaryotic translation initiation factor 4E, GLYCEROL | Authors: | Warminski, M, Nowak, E, Rydzik, A.M, Kowalska, J, Jemielity, J, Nowotny, M. | Deposit date: | 2016-04-03 | Release date: | 2017-05-10 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.867 Å) | Cite: | mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation. Nucleic Acids Res., 45, 2017
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1L8B
| Cocrystal Structure of the Messenger RNA 5' Cap-binding Protein (eIF4E) bound to 7-methylGpppG | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E | Authors: | Niedzwiecka, A, Marcotrigiano, J, Stepinski, J, Jankowska-Anyszka, M, Wyslouch-Cieszynska, A, Dadlez, M, Gingras, A.-C, Mak, P, Darzynkiewicz, E, Sonenberg, N. | Deposit date: | 2002-03-19 | Release date: | 2002-06-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins. J.Mol.Biol., 319, 2002
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5T46
| Crystal structure of the human eIF4E-eIF4G complex | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4 gamma 1, Eukaryotic translation initiation factor 4E, ... | Authors: | Gruener, S, Peter, D, Weber, R, Wohlbold, L, Chung, M.-Y, Weichenrieder, O, Valkov, E, Igreja, C, Izaurralde, E. | Deposit date: | 2016-08-29 | Release date: | 2016-10-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation. Mol.Cell, 64, 2016
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5ABX
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5ABY
| Complex of C. elegans eIF4E-3 with the 4E-binding protein Mextli | Descriptor: | 4E-BINDING PROTEIN MEXTLI, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-3, GLYCEROL, ... | Authors: | Peter, D, Weichenrieder, O. | Deposit date: | 2015-08-09 | Release date: | 2015-09-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Mextli Proteins Use Both Canonical Bipartite and Novel Tripartite Binding Modes to Form Eif4E Complexes that Display Differential Sensitivity to 4E-BP Regulation Genes Dev., 29, 2015
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5ABU
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5ABV
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5WB5
| Leishmania IF4E-1 bound to Leishmania 4E-IP1 | Descriptor: | DI(HYDROXYETHYL)ETHER, Putative eukaryotic translation initiation factor eIF-4E, Uncharacterized protein | Authors: | Leger-Abraham, M, Meleppattu, S, Arthanari, H, Zinoviev, A, Boeszoermenyi, A, Wagner, G, Shapira, M. | Deposit date: | 2017-06-27 | Release date: | 2018-03-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for LeishIF4E-1 modulation by an interacting protein in the human parasite Leishmania major. Nucleic Acids Res., 46, 2018
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2V8W
| Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives | Descriptor: | EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1, [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE | Authors: | Brown, C.J, Mcnae, I, Fischer, P.M, Walkinshaw, M.D. | Deposit date: | 2007-08-16 | Release date: | 2007-08-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystallographic and Mass Spectrometric Characterisation of Eif4E with N(7)-Alkylated CAP Derivatives. J.Mol.Biol., 372, 2007
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5NVN
| Crystal structure of the human 4EHP-4E-BP1 complex | Descriptor: | Eukaryotic translation initiation factor 4E type 2, Eukaryotic translation initiation factor 4E-binding protein 1, FORMIC ACID | Authors: | Peter, D, Sandmeir, F, Valkov, E. | Deposit date: | 2017-05-04 | Release date: | 2017-07-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression. Genes Dev., 31, 2017
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5NVM
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5NVK
| Crystal structure of the human 4EHP-GIGYF1 complex | Descriptor: | Eukaryotic translation initiation factor 4E type 2, GRB10-interacting GYF protein 1 | Authors: | Peter, D, Valkov, E. | Deposit date: | 2017-05-04 | Release date: | 2017-07-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression. Genes Dev., 31, 2017
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5NVL
| Crystal structure of the human 4EHP-GIGYF2 complex | Descriptor: | Eukaryotic translation initiation factor 4E type 2, GRB10-interacting GYF protein 2 | Authors: | Peter, D, Valkov, E. | Deposit date: | 2017-05-04 | Release date: | 2017-07-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression. Genes Dev., 31, 2017
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2V8Y
| Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives | Descriptor: | EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1, P-FLUORO-7-BENZYL GUANINE MONOPHOSPHATE | Authors: | Brown, C.J, Mcnae, I, Fischer, P.M, Walkinshaw, M.D. | Deposit date: | 2007-08-16 | Release date: | 2007-08-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystallographic and Mass Spectrometric Characterisation of Eif4E with N(7)-Alkylated CAP Derivatives. J.Mol.Biol., 372, 2007
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2V8X
| Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives | Descriptor: | 7-BENZYL GUANINE MONOPHOSPHATE, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1 | Authors: | Brown, C.J, Mcnae, I, Fischer, P.M, Walkinshaw, M.D. | Deposit date: | 2007-08-16 | Release date: | 2007-08-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystallographic and Mass Spectrometric Characterisation of Eif4E with N(7)-Alkylated CAP Derivatives. J.Mol.Biol., 372, 2007
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2W97
| Crystal Structure of eIF4E Bound to Glycerol and eIF4G1 peptide | Descriptor: | EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, GLYCEROL, ... | Authors: | Brown, C.J, Verma, C.S, Walkinshaw, M.D, Lane, D.P. | Deposit date: | 2009-01-22 | Release date: | 2010-03-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Crystallization of eIF4E complexed with eIF4GI peptide and glycerol reveals distinct structural differences around the cap-binding site. Cell Cycle, 8, 2009
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5OSX
| Translation initiation factor 4E in complex with m7G(5'S)ppp(5'S)G mRNA 5' cap analog | Descriptor: | Eukaryotic translation initiation factor 4E, POTASSIUM ION, [(2~{S},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-3~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl-[[[(3~{R},4~{S})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-phosphinic acid | Authors: | Warminski, M, Nowak, E, Wojtczak, B.A, Fac-Dabrowska, K, Kubacka, D, Nowicka, A, Sikorski, P.J, Kowalska, J, Jemielity, J, Nowotny, M. | Deposit date: | 2017-08-18 | Release date: | 2018-05-02 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | 5'-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes. J. Am. Chem. Soc., 140, 2018
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2WMC
| Crystal structure of eukaryotic initiation factor 4E from Pisum sativum | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E | Authors: | Ashby, J.A, Stevenson, C.E.M, Maule, A.J, Lawson, D.M. | Deposit date: | 2009-06-30 | Release date: | 2010-09-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure-Based Mutational Analysis of Eif4E in Relation to Sbm1 Resistance to Pea Seed-Borne Mosaic Virus in Pea. Plos One, 6, 2011
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2GPQ
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5EI3
| Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | Descriptor: | Eukaryotic translation initiation factor 4 gamma, Eukaryotic translation initiation factor 4E, SULFATE ION, ... | Authors: | Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. | Deposit date: | 2015-10-29 | Release date: | 2016-09-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124, 2016
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