8I18
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![BU of 8i18 by Molmil](/molmil-images/mine/8i18) | |
8G9D
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![BU of 8g9d by Molmil](/molmil-images/mine/8g9d) | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 5- phosphonodifluoroacetamide inositol pentakisphosphate (5-PCF2Am-InsP5), an analogue of 5-InsP7 | Descriptor: | (1,1-difluoro-2-oxo-2-{[(1s,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl]amino}ethyl)phosphonic acid, Diphosphoinositol polyphosphate phosphohydrolase 1 | Authors: | Zong, G, Wang, H, Shears, S. | Deposit date: | 2023-02-21 | Release date: | 2024-01-03 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs. Chemistry, 29, 2023
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8G9C
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![BU of 8g9c by Molmil](/molmil-images/mine/8g9c) | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 5- difluoromethylenebisphosphonate inositol pentakisphosphate (5-PCF2P-IP5), an analogue of 5-InsP7 | Descriptor: | CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, FLUORIDE ION, ... | Authors: | Zong, G, Wang, H, Shears, S. | Deposit date: | 2023-02-21 | Release date: | 2024-01-03 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs. Chemistry, 29, 2023
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8DPA
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![BU of 8dpa by Molmil](/molmil-images/mine/8dpa) | Crystal structure of the homodimeric AvrM14-B Nudix hydrolase effector from Melampsora lini | Descriptor: | AvrM14-B, SULFATE ION | Authors: | McCombe, C.L, Outram, M.A, Ericsson, D.J, Williams, S.J. | Deposit date: | 2022-07-15 | Release date: | 2023-01-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | A rust-fungus Nudix hydrolase effector decaps mRNA in vitro and interferes with plant immune pathways. New Phytol., 239, 2023
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8DP9
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![BU of 8dp9 by Molmil](/molmil-images/mine/8dp9) | Crystal structure of the monomeric AvrM14-B Nudix hydrolase effector from Melampsora lini | Descriptor: | AvrM14-B, SULFATE ION | Authors: | McCombe, C.L, Outram, M.A, Ericsson, D.J, Williams, S.J. | Deposit date: | 2022-07-15 | Release date: | 2023-01-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | A rust-fungus Nudix hydrolase effector decaps mRNA in vitro and interferes with plant immune pathways. New Phytol., 239, 2023
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8DP8
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![BU of 8dp8 by Molmil](/molmil-images/mine/8dp8) | |
8A3A
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![BU of 8a3a by Molmil](/molmil-images/mine/8a3a) | MTH1 in complex with TH013074 | Descriptor: | 4-(4-methylphenyl)-1~{H}-quinazolin-2-one, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION | Authors: | Liu, H, Scaletti, E, Stenmark, P. | Deposit date: | 2022-06-07 | Release date: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | MTH1 in complex with TH013074 To Be Published
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8A34
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![BU of 8a34 by Molmil](/molmil-images/mine/8a34) | MTH1 in complex with TH013071 | Descriptor: | 5-(2-phenylphenyl)-1H-pyrimidine-2,4-dione, 7,8-dihydro-8-oxoguanine triphosphatase, ACETATE ION, ... | Authors: | Liu, H, Scaletti, E, Stenmark, P. | Deposit date: | 2022-06-07 | Release date: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | MTH1 in complex with TH013071 To Be Published
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8A0T
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![BU of 8a0t by Molmil](/molmil-images/mine/8a0t) | MTH1 in complex with TH012532 | Descriptor: | 5-(phenylmethyl)pyrimidine-2,4-diol, 7,8-dihydro-8-oxoguanine triphosphatase, ACETATE ION, ... | Authors: | Scaletti, E, Stenmark, P. | Deposit date: | 2022-05-30 | Release date: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | MTH1 in complex with TH012532 To Be Published
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8A0S
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![BU of 8a0s by Molmil](/molmil-images/mine/8a0s) | MTH1 in complex with TH013350 | Descriptor: | 4-[(2-chlorophenyl)methylsulfanyl]-5~{H}-pyrimidin-2-one, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION | Authors: | Liu, H, Scaletti, E, Stenmark, P. | Deposit date: | 2022-05-30 | Release date: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | MTH1 in complex with TH013350 To Be Published
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8A07
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![BU of 8a07 by Molmil](/molmil-images/mine/8a07) | |
7X9O
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![BU of 7x9o by Molmil](/molmil-images/mine/7x9o) | Crystal structure of MutT-8-oxo-dGMP complex with Mg2+ ions: Reaction using Mg2+ | Descriptor: | 7,8-dihydro-8-oxoguanine-triphosphatase, 8-OXO-2'-DEOXY-GUANOSINE-5'-MONOPHOSPHATE, MAGNESIUM ION, ... | Authors: | Nakamura, T, Yamagata, Y. | Deposit date: | 2022-03-15 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Visualization of mutagenic nucleotide processing by Escherichia coli MutT, a Nudix hydrolase. Proc.Natl.Acad.Sci.USA, 119, 2022
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7X9N
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![BU of 7x9n by Molmil](/molmil-images/mine/7x9n) | Crystal structure of MutT-8-oxo-dGTP complex with three Mg2+ ions: Reaction using Mg2+ | Descriptor: | 7,8-dihydro-8-oxoguanine-triphosphatase, 8-OXO-2'-DEOXY-GUANOSINE-5'-MONOPHOSPHATE, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Nakamura, T, Yamagata, Y. | Deposit date: | 2022-03-15 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Visualization of mutagenic nucleotide processing by Escherichia coli MutT, a Nudix hydrolase. Proc.Natl.Acad.Sci.USA, 119, 2022
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7X9L
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![BU of 7x9l by Molmil](/molmil-images/mine/7x9l) | Crystal structure of MutT-8-oxo-dGTP complex: Reaction for 4 hr using 10 mM Mn2+ | Descriptor: | 7,8-dihydro-8-oxoguanine-triphosphatase, 8-OXO-2'-DEOXY-GUANOSINE-5'-MONOPHOSPHATE, MANGANESE (II) ION, ... | Authors: | Nakamura, T, Yamagata, Y. | Deposit date: | 2022-03-15 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Visualization of mutagenic nucleotide processing by Escherichia coli MutT, a Nudix hydrolase. Proc.Natl.Acad.Sci.USA, 119, 2022
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7X9K
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![BU of 7x9k by Molmil](/molmil-images/mine/7x9k) | Crystal structure of MutT-8-oxo-dGTP complex: Reaction for 2 hr using 10 mM Mn2+ | Descriptor: | 7,8-dihydro-8-oxoguanine-triphosphatase, 8-OXO-2'-DEOXY-GUANOSINE-5'-MONOPHOSPHATE, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Nakamura, T, Yamagata, Y. | Deposit date: | 2022-03-15 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Visualization of mutagenic nucleotide processing by Escherichia coli MutT, a Nudix hydrolase. Proc.Natl.Acad.Sci.USA, 119, 2022
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7X9J
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![BU of 7x9j by Molmil](/molmil-images/mine/7x9j) | Crystal structure of MutT-8-oxo-dGTP complex: Reaction for 24 hr using 5 mM Mn2+ | Descriptor: | 7,8-dihydro-8-oxoguanine-triphosphatase, 8-OXO-2'-DEOXY-GUANOSINE-5'-MONOPHOSPHATE, MANGANESE (II) ION, ... | Authors: | Nakamura, T, Yamagata, Y. | Deposit date: | 2022-03-15 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Visualization of mutagenic nucleotide processing by Escherichia coli MutT, a Nudix hydrolase. Proc.Natl.Acad.Sci.USA, 119, 2022
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7X9I
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![BU of 7x9i by Molmil](/molmil-images/mine/7x9i) | Crystal structure of MutT-8-oxo-dGTP complex: Reaction for 12 hr using 5 mM Mn2+ | Descriptor: | 7,8-dihydro-8-oxoguanine-triphosphatase, 8-OXO-2'-DEOXY-GUANOSINE-5'-MONOPHOSPHATE, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Nakamura, T, Yamagata, Y. | Deposit date: | 2022-03-15 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Visualization of mutagenic nucleotide processing by Escherichia coli MutT, a Nudix hydrolase. Proc.Natl.Acad.Sci.USA, 119, 2022
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7X9H
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![BU of 7x9h by Molmil](/molmil-images/mine/7x9h) | Crystal structure of MutT-8-oxo-dGTP complex: Reaction for 9 hr using 5 mM Mn2+ | Descriptor: | 7,8-dihydro-8-oxoguanine-triphosphatase, 8-OXO-2'-DEOXY-GUANOSINE-5'-MONOPHOSPHATE, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Nakamura, T, Yamagata, Y. | Deposit date: | 2022-03-15 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Visualization of mutagenic nucleotide processing by Escherichia coli MutT, a Nudix hydrolase. Proc.Natl.Acad.Sci.USA, 119, 2022
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7WWA
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![BU of 7wwa by Molmil](/molmil-images/mine/7wwa) | Crystal structure of MutT-8-oxo-dGTP complex: Reaction for 2.5 hr in 20 mM Mn2+ | Descriptor: | 7,8-dihydro-8-oxoguanine-triphosphatase, 8-OXO-2'-DEOXY-GUANOSINE-5'-MONOPHOSPHATE, MANGANESE (II) ION, ... | Authors: | Nakamura, T, Yamagata, Y. | Deposit date: | 2022-02-12 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Visualization of mutagenic nucleotide processing by Escherichia coli MutT, a Nudix hydrolase. Proc.Natl.Acad.Sci.USA, 119, 2022
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7WW9
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![BU of 7ww9 by Molmil](/molmil-images/mine/7ww9) | Crystal structure of MutT-8-oxo-dGTP complex: Reaction for 1.5 hr in 20 mM Mn2+ | Descriptor: | 7,8-dihydro-8-oxoguanine-triphosphatase, 8-OXO-2'-DEOXY-GUANOSINE-5'-MONOPHOSPHATE, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Nakamura, T, Yamagata, Y. | Deposit date: | 2022-02-12 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Visualization of mutagenic nucleotide processing by Escherichia coli MutT, a Nudix hydrolase. Proc.Natl.Acad.Sci.USA, 119, 2022
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7WW8
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![BU of 7ww8 by Molmil](/molmil-images/mine/7ww8) | Crystal structure of MutT-8-oxo-dGTP complex: Reaction for 5 hr in 5 mM Mn2+ | Descriptor: | 7,8-dihydro-8-oxoguanine-triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... | Authors: | Nakamura, T, Yamagata, Y. | Deposit date: | 2022-02-12 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Visualization of mutagenic nucleotide processing by Escherichia coli MutT, a Nudix hydrolase. Proc.Natl.Acad.Sci.USA, 119, 2022
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7WW7
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![BU of 7ww7 by Molmil](/molmil-images/mine/7ww7) | Crystal structure of MutT-8-oxo-dGTP complex: Reaction for 1 hr in 5 mM Mn2+ | Descriptor: | 7,8-dihydro-8-oxoguanine-triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... | Authors: | Nakamura, T, Yamagata, Y. | Deposit date: | 2022-02-12 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Visualization of mutagenic nucleotide processing by Escherichia coli MutT, a Nudix hydrolase. Proc.Natl.Acad.Sci.USA, 119, 2022
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7WW6
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![BU of 7ww6 by Molmil](/molmil-images/mine/7ww6) | Crystal structure of MutT-8-oxo-dGTP complex: Reaction for 20 min in 5 mM Mn2+ | Descriptor: | 7,8-dihydro-8-oxoguanine-triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... | Authors: | Nakamura, T, Yamagata, Y. | Deposit date: | 2022-02-12 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.36 Å) | Cite: | Visualization of mutagenic nucleotide processing by Escherichia coli MutT, a Nudix hydrolase. Proc.Natl.Acad.Sci.USA, 119, 2022
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7WW5
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![BU of 7ww5 by Molmil](/molmil-images/mine/7ww5) | Crystal structure of MutT-8-oxo-dGTP complex | Descriptor: | 7,8-dihydro-8-oxoguanine-triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, SODIUM ION, ... | Authors: | Nakamura, T, Yamagata, Y. | Deposit date: | 2022-02-12 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Visualization of mutagenic nucleotide processing by Escherichia coli MutT, a Nudix hydrolase. Proc.Natl.Acad.Sci.USA, 119, 2022
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7TN4
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![BU of 7tn4 by Molmil](/molmil-images/mine/7tn4) | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 3-diphosphoinositol 1,2,4,5-tetrakisphosphate (3-PP-IP4), Mg and Fluoride ion | Descriptor: | (1R,2S,3R,4R,5S,6S)-4-hydroxy-2,3,5,6-tetrakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, ... | Authors: | Zong, G, Wang, H, Shears, S.B. | Deposit date: | 2022-01-20 | Release date: | 2022-06-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural and catalytic analyses of the InsP 6 kinase activities of higher plant ITPKs. Faseb J., 36, 2022
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