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1DS3	CRYSTAL STRUCTURE OF OMTKY3-CH2-ASP19I Descriptor: OVOMUCOID Authors: Bateman, K.S, Huang, K, Anderson, S, Lu, W, Qasim, M.A, Laskowski Jr, M, James, M.N.G. Deposit date: 2000-01-06 Release date: 2001-01-31 Last modified: 2021-11-03 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Contribution of peptide bonds to inhibitor-protease binding: crystal structures of the turkey ovomucoid third domain backbone variants OMTKY3-Pro18I and OMTKY3-psi[COO]-Leu18I in complex with Streptomyces griseus proteinase B (SGPB) and the structure of the free inhibitor, OMTKY-3-psi[CH2NH2+]-Asp19I J.Mol.Biol., 305, 2001
1UVF	Solution Structure of the structured part of the 15th Domain of LEKTI Descriptor: SERINE PROTEINASE INHIBITOR KAZAL TYPE 5 Authors: Vitzithum, K, Roesch, P, Marx, U.C. Deposit date: 2004-01-20 Release date: 2005-04-14 Last modified: 2011-07-13 Method: SOLUTION NMR Cite: The Solution Structure of a Chimeric Lekti Domain Reveals a Chameleon Sequence Biochemistry, 43, 2004
1TUS	SOLUTION STRUCTURE OF REACTIVE-SITE HYDROLYZED TURKEY OVOMUCOID THIRD DOMAIN BY NUCLEAR MAGNETIC RESONANCE AND DISTANCE GEOMETRY METHODS Descriptor: OVOMUCOID Authors: Walkenhorst, W.F, Krezel, A.M, Rhyu, G.I, Markley, J.L. Deposit date: 1994-07-06 Release date: 1994-10-15 Last modified: 2017-11-29 Method: SOLUTION NMR Cite: Solution structure of reactive-site hydrolyzed turkey ovomucoid third domain by nuclear magnetic resonance and distance geometry methods. J.Mol.Biol., 242, 1994
1TUR	SOLUTION STRUCTURE OF TURKEY OVOMUCOID THIRD DOMAIN AS DETERMINED FROM NUCLEAR MAGNETIC RESONANCE DATA Descriptor: OVOMUCOID Authors: Krezel, A.M, Darba, P, Robertson, A.D, Fejzo, J, Macura, S, Markley, J.L. Deposit date: 1994-07-06 Release date: 1994-10-15 Last modified: 2017-11-29 Method: SOLUTION NMR Cite: Solution structure of turkey ovomucoid third domain as determined from nuclear magnetic resonance data. J.Mol.Biol., 242, 1994
1UVG	Solution structure of the 15th Domain of LEKTI Descriptor: SERINE PROTEINASE INHIBITOR KAZAL TYPE 5 Authors: Vitzithum, K, Roesch, P, Marx, U.C. Deposit date: 2004-01-20 Release date: 2005-04-14 Last modified: 2019-10-30 Method: SOLUTION NMR Cite: The Solution Structure of a Chimeric Lekti Domain Reveals a Chameleon Sequence Biochemistry, 43, 2004
7E50	Crystal structure of human microplasmin in complex with kazal-type inhibitor AaTI Descriptor: AAEL006007-PA, GLYCEROL, Plasminogen, ... Authors: Varsha, A.W, Jobichen, C, Mok, Y.K. Deposit date: 2021-02-16 Release date: 2022-02-16 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal structure of Aedes aegypti trypsin inhibitor in complex with mu-plasmin reveals role for scaffold stability in Kazal-type serine protease inhibitor. Protein Sci., 31, 2022
8IVD	COMPLEX STRUCTURE OF CD93-IGFBP7 Descriptor: Insulin-like growth factor-binding protein 7,Complement component C1q receptor Authors: Xu, Y.M, Song, G.J. Deposit date: 2023-03-27 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (3.24 Å) Cite: structural insight into CD93 recognition by IGFBP7 To Be Published
5DAE	Kazal type inhibitor from salivary glands of Aedes aegypti mosquito Descriptor: AAEL006007-PA Authors: Torquato, R.J.S, Pereira, P.J.B, Tanaka, A.S. Deposit date: 2015-08-19 Release date: 2016-09-07 Last modified: 2020-01-01 Method: X-RAY DIFFRACTION (1.4 Å) Cite: High-resolution structure of a Kazal-type serine protease inhibitor from the dengue vector Aedes aegypti. Acta Crystallogr F Struct Biol Commun, 73, 2017
6KBR	Crystal structure of Human KLK4 and SPINK2 derived KLK4 inhibitor complex Descriptor: GLYCEROL, K41043, Kallikrein-4 Authors: Kawaguchi, Y, Nishimiya, D. Deposit date: 2019-06-26 Release date: 2019-07-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: A protein scaffold, engineered SPINK2, for generation of inhibitors with high affinity and specificity against target proteases. Sci Rep, 9, 2019
4OVO	REFINED X-RAY CRYSTAL STRUCTURES OF THE REACTIVE SITE MODIFIED OVOMUCOID INHIBITOR THIRD DOMAINS FROM SILVER PHEASANT (OMSVP3(ASTERISK)) AND FROM JAPANESE QUAIL (OMJPQ3(ASTERISK)) Descriptor: OVOMUCOID THIRD DOMAIN CLEAVED RDI Authors: Musil, D, Bode, W. Deposit date: 1991-05-13 Release date: 1993-01-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Refined X-ray crystal structures of the reactive site modified ovomucoid inhibitor third domains from silver pheasant (OMSVP3*) and from Japanese quail (OMJPQ3*). J.Mol.Biol., 220, 1991
2SGD	ASP 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B AT PH 10.7 Descriptor: Ovomucoid, PHOSPHATE ION, POTASSIUM ION, ... Authors: Huang, K, Lu, W, Anderson, S, Laskowski Jr, M, James, M.N.G. Deposit date: 1999-03-25 Release date: 2003-08-26 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Recruitment of a Buried K+ Ion to Stabilize the Negative Charge of Ionized P1 in the Hydrophobic Pocket: Crystal Structures of Glu18, Gln18, Asp18 and Asn18 Variants of Turkey Ovomucoid Inhibitor Third Domain Complexed with Streptomyces griseus Protease B at Various pHs To be Published
7QE9	Human cationic trypsin (TRY1) complexed with serine protease inhibitor Kazal type 1 N34S (SPINK1 N34S) Descriptor: SULFATE ION, Serine protease inhibitor Kazal-type 1, Trypsin-1 Authors: Nagel, F, Palm, G.J, Delcea, M, Lammers, M. Deposit date: 2021-12-01 Release date: 2022-03-30 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural and Biophysical Insights into SPINK1 Bound to Human Cationic Trypsin. Int J Mol Sci, 23, 2022
7QE8	Human cationic trypsin (TRY1) complexed with serine protease inhibitor Kazal type 1 (SPINK1) Descriptor: SULFATE ION, Serine protease inhibitor Kazal-type 1, Trypsin-1 Authors: Nagel, F, Palm, G.J, Delcea, M, Lammers, M. Deposit date: 2021-12-01 Release date: 2022-03-30 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural and Biophysical Insights into SPINK1 Bound to Human Cationic Trypsin. Int J Mol Sci, 23, 2022
2V53	Crystal structure of a SPARC-collagen complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COLLAGEN ALPHA-1(III) CHAIN, ... Authors: Hohenester, E, Sasaki, T, Giudici, C, Farndale, R.W, Bachinger, H.P. Deposit date: 2008-10-01 Release date: 2008-11-25 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structural Basis of Sequence-Specific Collagen Recognition by Sparc. Proc.Natl.Acad.Sci.USA, 105, 2008
1HJA	LYS 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH ALPHA-CHYMOTRYPSIN Descriptor: ALPHA-CHYMOTRYPSIN, OVOMUCOID INHIBITOR Authors: Ding, J.-H, James, M.N.G. Deposit date: 1997-07-09 Release date: 1998-01-14 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structure of Lys18 Variant of Turkey Ovomucoid Inhibitor Third Domain Complexed with Alpha-Chymotrypsin at 2.3 A To be Published
2BUS	SOLUTION CONFORMATION OF PROTEINASE INHIBITOR IIA FROM BULL SEMINAL PLASMA BY 1H NUCLEAR MAGNETIC RESONANCE AND DISTANCE GEOMETRY Descriptor: PROTEINASE INHIBITOR IIA Authors: Guntert, P, Williamson, M.P, Havel, T.F, Wuthrich, K. Deposit date: 1990-05-14 Release date: 1991-04-15 Last modified: 2019-12-25 Method: SOLUTION NMR Cite: Solution conformation of proteinase inhibitor IIA from bull seminal plasma by 1H nuclear magnetic resonance and distance geometry. J.Mol.Biol., 182, 1985
1YU6	Crystal Structure of the Subtilisin Carlsberg:OMTKY3 Complex Descriptor: CALCIUM ION, Ovomucoid, Subtilisin Carlsberg Authors: Maynes, J.T, Cherney, M.M, Qasim, M.A, Laskowski Jr, M, James, M.N.G. Deposit date: 2005-02-11 Release date: 2005-05-03 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Structure of the subtilisin Carlsberg-OMTKY3 complex reveals two different ovomucoid conformations. Acta Crystallogr.,Sect.D, 61, 2005
3TJQ	N-domain of HtrA1 Descriptor: CHLORIDE ION, GLYCEROL, PLATINUM (II) ION, ... Authors: Eigenbrot, C, Ultsch, M. Deposit date: 2011-08-24 Release date: 2012-05-16 Last modified: 2012-06-27 Method: X-RAY DIFFRACTION (2.001 Å) Cite: Structural and Functional Analysis of HtrA1 and Its Subdomains. Structure, 20, 2012
3SGB	STRUCTURE OF THE COMPLEX OF STREPTOMYCES GRISEUS PROTEASE B AND THE THIRD DOMAIN OF THE TURKEY OVOMUCOID INHIBITOR AT 1.8 ANGSTROMS RESOLUTION Descriptor: PROTEINASE B (SGPB), TURKEY OVOMUCOID INHIBITOR (OMTKY3) Authors: Read, R.J, Fujinaga, M, Sielecki, A.R, James, M.N.G. Deposit date: 1983-01-21 Release date: 1983-07-12 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure of the complex of Streptomyces griseus protease B and the third domain of the turkey ovomucoid inhibitor at 1.8-A resolution. Biochemistry, 22, 1983
3SGQ	GLN 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B AT PH 10.7 Descriptor: Ovomucoid, PHOSPHATE ION, Streptogrisin B Authors: Huang, K, Lu, W, Anderson, S, Laskowski Jr, M, James, M.N.G. Deposit date: 1999-03-25 Release date: 2003-08-26 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Recruitment of a Buried K+ Ion to Stabilize the Negative Charge of Ionized P1 in the Hydrophobic Pocket: Crystal Structures of Glu18, Gln18, Asp18 and Asn18 Variants of Turkey Ovomucoid Inhibitor Third Domain Complexed with Streptomyces griseus Protease B at Various pH's To be Published
3QTL	Structural Basis for Dual-inhibition Mechanism of a Non-classical Kazal-type Serine Protease Inhibitor from Horseshoe Crab in Complex with Subtilisin Descriptor: Kazal-type serine protease inhibitor SPI-1, Subtilisin-like serin protease Authors: Shenoy, R.T, Sivaraman, J. Deposit date: 2011-02-23 Release date: 2011-06-01 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural basis for dual-inhibition mechanism of a non-classical kazal-type serine protease inhibitor from horseshoe crab in complex with subtilisin. Plos One, 6, 2011
2F3C	Crystal structure of infestin 1, a Kazal-type serineprotease inhibitor, in complex with trypsin Descriptor: CALCIUM ION, Cationic trypsin, SULFATE ION, ... Authors: Campos, I.T.N, Tanaka, A.S, Barbosa, J.A.R.G. Deposit date: 2005-11-20 Release date: 2006-12-05 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The Kazal-type inhibitors infestins 1 and 4 differ in specificity but are similar in three-dimensional structure. Acta Crystallogr.,Sect.D, 68, 2012
2SGP	PRO 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B AT PH 6.5 Descriptor: OVOMUCOID INHIBITOR, PHOSPHATE ION, PROTEINASE B Authors: Huang, K, Lu, W, Anderson, S, Laskowski Jr, M, James, M.N.G. Deposit date: 1999-03-25 Release date: 2001-01-31 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Contribution of peptide bonds to inhibitor-protease binding: crystal structures of the turkey ovomucoid third domain backbone variants OMTKY3-Pro18I and OMTKY3-psi[COO]-Leu18I in complex with Streptomyces griseus proteinase B (SGPB) and the structure of the free inhibitor, OMTKY-3-psi[CH2NH2+]-Asp19I J.Mol.Biol., 305, 2001
2SGQ	GLN 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B AT PH 6.5 Descriptor: Ovomucoid, PHOSPHATE ION, Streptogrisin B Authors: Huang, K, Lu, W, Anderson, S, Laskowski Jr, M, James, M.N.G. Deposit date: 1999-03-25 Release date: 2003-08-26 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Recruitment of a Buried K+ Ion to Stabilize the Negative Charge of Ionized P1 in the Hydrophobic Pocket: Crystal Structures of Glu18, Gln18, Asp18 and Asn18 Variants of Turkey Ovomucoid Inhibitor Third Domain Complexed with Streptomyces griseus Protease B at Various pH's To be Published
2SGE	GLU 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B AT PH 10.7 Descriptor: Ovomucoid, PHOSPHATE ION, POTASSIUM ION, ... Authors: Huang, K, Lu, W, Anderson, S, Laskowski Jr, M, James, M.N.G. Deposit date: 1999-03-25 Release date: 2003-08-26 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Water molecules participate in proteinase-inhibitor interactions: crystal structures of Leu18, Ala18, and Gly18 variants of turkey ovomucoid inhibitor third domain complexed with Streptomyces griseus proteinase B. Protein Sci., 4, 1995

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