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7NQ0
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BU of 7nq0 by Molmil
C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH oxabicyclo(hexan-6-yl)-N2-methyl-6-((S)-1-phenylethyl)pyridine-2,4-dicarboxamide
Descriptor: 1,2-ETHANEDIOL, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Bromodomain-containing protein 2, ...
Authors:Chung, C.
Deposit date:2021-02-28
Release date:2021-07-21
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Identification of a Series of N -Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins.
J.Med.Chem., 64, 2021
7NQ3
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BU of 7nq3 by Molmil
C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH N4-((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-6-((S)-methoxy(phenyl)methyl)-N2-methylpyridine-2,4-dicarboxamide
Descriptor: 1,2-ETHANEDIOL, 6-[(~{S})-methoxy(phenyl)methyl]-~{N}2-methyl-~{N}4-[(1~{S},5~{R})-3-oxabicyclo[3.1.0]hexan-6-yl]pyridine-2,4-dicarboxamide, Bromodomain-containing protein 2
Authors:Chung, C.
Deposit date:2021-02-28
Release date:2021-07-21
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.603 Å)
Cite:Identification of a Series of N -Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins.
J.Med.Chem., 64, 2021
8C6P
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BU of 8c6p by Molmil
Fragment screening hit I bound to endothiapepsin
Descriptor: 4-[(2-azanyl-4-methyl-1,3-thiazol-5-yl)methyl]benzenecarbonitrile, Endothiapepsin, GLYCEROL
Authors:Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D.
Deposit date:2023-01-12
Release date:2023-05-24
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library.
J.Med.Chem., 66, 2023
8C6Q
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BU of 8c6q by Molmil
Fragment screening hit II bound to endothiapepsin
Descriptor: 3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)aniline, Endothiapepsin, GLYCEROL
Authors:Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D.
Deposit date:2023-01-12
Release date:2023-05-24
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library.
J.Med.Chem., 66, 2023
8C70
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BU of 8c70 by Molmil
Pyrrolidine fragment 1 bound to endothiapepsin
Descriptor: (3~{R},4~{R})-4-[4-[(5-bromanylpyridin-3-yl)oxymethyl]-1,2,3-triazol-1-yl]pyrrolidin-3-ol, Endothiapepsin
Authors:Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D.
Deposit date:2023-01-12
Release date:2023-05-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library.
J.Med.Chem., 66, 2023
8C71
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BU of 8c71 by Molmil
Pyrrolidine fragment 5b bound to endothiapepsin
Descriptor: (3~{R},4~{R})-4-(3,4-dihydro-1~{H}-isoquinolin-2-yl)pyrrolidin-3-ol, Endothiapepsin, GLYCEROL
Authors:Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D.
Deposit date:2023-01-12
Release date:2023-05-24
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library.
J.Med.Chem., 66, 2023
8C72
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BU of 8c72 by Molmil
Pyrrolidine fragment 10b bound to endothiapepsin
Descriptor: (3~{S},4~{S})-4-(4-pyridin-2-yl-1,2,3-triazol-1-yl)piperidin-3-ol, Endothiapepsin, GLYCEROL
Authors:Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D.
Deposit date:2023-01-12
Release date:2023-05-24
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library.
J.Med.Chem., 66, 2023
8C74
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BU of 8c74 by Molmil
Pyrrolidine fragment 10d bound to endothiapepsin
Descriptor: (3~{R},4~{R})-4-[4-[(4-azanylphenoxy)methyl]-1,2,3-triazol-1-yl]pyrrolidin-3-ol, Endothiapepsin, GLYCEROL
Authors:Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D.
Deposit date:2023-01-12
Release date:2023-05-24
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library.
J.Med.Chem., 66, 2023
8C6S
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BU of 8c6s by Molmil
Fragment screening hit III bound to endothiapepsin
Descriptor: 4-(1,4-diazepan-1-ylsulfonyl)isoquinoline, Endothiapepsin, GLYCEROL
Authors:Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D.
Deposit date:2023-01-12
Release date:2023-05-24
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library.
J.Med.Chem., 66, 2023
8C6T
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BU of 8c6t by Molmil
Fragment screening hit IV bound to endothiapepsin
Descriptor: 1-[3,5-bis(chloranyl)phenoxy]propan-2-amine, Endothiapepsin, GLYCEROL
Authors:Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D.
Deposit date:2023-01-12
Release date:2023-05-24
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library.
J.Med.Chem., 66, 2023
8CK3
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BU of 8ck3 by Molmil
STRUCTURE OF HIF2A-ARNT HETERODIMER IN COMPLEX WITH (S)-1-(3,5-Difluoro-phenyl)-5,5-difluoro-3-methanesulfonyl-5,6-dihydro-4H-cyclopenta[c]thiophen-4-ol
Descriptor: (4~{S})-1-[3,5-bis(fluoranyl)phenyl]-5,5-bis(fluoranyl)-3-methylsulfonyl-4,6-dihydrocyclopenta[c]thiophen-4-ol, Aryl hydrocarbon receptor nuclear translocator, DIMETHYL SULFOXIDE, ...
Authors:Musil, D, Lehmannn, M, Diehl, L.
Deposit date:2023-02-14
Release date:2023-07-19
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.707 Å)
Cite:Discovery of Cycloalkyl[ c ]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2 alpha Inhibitors.
J.Med.Chem., 66, 2023
8CK8
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BU of 8ck8 by Molmil
STRUCTURE OF HIF2A-ARNT HETERODIMER IN COMPLEX WITH (S)-1-Cyclohexyloxy-5,5-difluoro-3-methanesulfonyl-5,6-dihydro-4H-cyclopenta[c]thiophen-4-ol
Descriptor: (4~{S})-1-cyclohexyloxy-5,5-bis(fluoranyl)-3-methylsulfonyl-4,6-dihydrocyclopenta[c]thiophen-4-ol, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
Authors:Musil, D.
Deposit date:2023-02-14
Release date:2023-07-19
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.302 Å)
Cite:Discovery of Cycloalkyl[ c ]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2 alpha Inhibitors.
J.Med.Chem., 66, 2023
8CK4
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BU of 8ck4 by Molmil
STRUCTURE OF HIF2A-ARNT HETERODIMER IN COMPLEX WITH (4S)-1-(3,5-difluorophenyl)-5,5-difluoro-3-methanesulfonyl-4,5,6,7-tetrahydro-2-benzothiophen-4-ol
Descriptor: (4~{S})-1-[3,5-bis(fluoranyl)phenyl]-5,5-bis(fluoranyl)-3-methylsulfonyl-6,7-dihydro-4~{H}-2-benzothiophen-4-ol, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
Authors:Musil, D.
Deposit date:2023-02-14
Release date:2023-07-19
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Discovery of Cycloalkyl[ c ]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2 alpha Inhibitors.
J.Med.Chem., 66, 2023
8TU3
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BU of 8tu3 by Molmil
Bruton's tyrosine kinase in complex with covalent inhibitor compound 10
Descriptor: 1-[(4R)-4-{[(6P,8S)-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}azepan-1-yl]propan-1-one, Tyrosine-protein kinase BTK
Authors:Metrick, C.M.
Deposit date:2023-08-15
Release date:2024-06-26
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.
J.Med.Chem., 67, 2024
8TU4
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BU of 8tu4 by Molmil
Bruton's tyrosine kinase in complex with covalent inhibitor compound 25
Descriptor: N-methyl-N-[(1S,3r)-3-methyl-3-{[(6M,8S)-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}cyclobutyl]propanamide, Tyrosine-protein kinase BTK
Authors:Metrick, C.M.
Deposit date:2023-08-15
Release date:2024-06-26
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.
J.Med.Chem., 67, 2024
8TU5
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BU of 8tu5 by Molmil
Bruton's tyrosine kinase in complex with covalent inhibitor compound 27
Descriptor: 1-[(1S,5S,6S)-6-methyl-6-{[(6M,8R)-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}-2-azabicyclo[3.2.0]heptan-2-yl]propan-1-one, Tyrosine-protein kinase BTK
Authors:Metrick, C.M.
Deposit date:2023-08-15
Release date:2024-06-26
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.
J.Med.Chem., 67, 2024
4ZYF
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BU of 4zyf by Molmil
Discovery of NVP-CGM097 - a highly potent and selective MDM2 inhibitor undergoing phase 1 clinical trials in p53wt tumors: Hdm2 (MDM2) complexed with NVP-CGM097
Descriptor: (S)-1-(4-chlorophenyl)-7-isopropoxy-6-methoxy-2-(4-(methyl(((1r,4S)-4-(4-methyl-3-oxopiperazin-1-yl)cyclohexyl)methyl)amino)phenyl)-1,2-dihydroisoquinolin-3(4H)-one, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2
Authors:Kallen, J.
Deposit date:2015-05-21
Release date:2015-07-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors.
J.Med.Chem., 58, 2015
6M1J
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BU of 6m1j by Molmil
The DNA Gyrase B ATP binding domain of PSEUDOMONAS AERUGINOSA in complex with compound 12x
Descriptor: 1-[5-[6-fluoranyl-8-(methylamino)-4-[3-(trifluoromethyl)pyrazol-1-yl]-9H-pyrido[2,3-b]indol-3-yl]pyrimidin-2-yl]cyclopropane-1-carboxylic acid, DIMETHYL SULFOXIDE, DNA gyrase subunit B, ...
Authors:Xu, Z.H, Zhou, Z.
Deposit date:2020-02-26
Release date:2020-09-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.701 Å)
Cite:Discovery of Pyrido[2,3-b]indole Derivatives with Gram-Negative Activity Targeting Both DNA Gyrase and Topoisomerase IV.
J.Med.Chem., 63, 2020
6M1S
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BU of 6m1s by Molmil
The DNA Gyrase B ATP binding domain of PSEUDOMONAS AERUGINOSA in complex with compound 12o
Descriptor: 3-[5-[8-(ethylamino)-6-fluoranyl-4-[3-(trifluoromethyl)pyrazol-1-yl]-9H-pyrido[2,3-b]indol-3-yl]pyrimidin-2-yl]oxy-2,2-dimethyl-propanoic acid, CHLORIDE ION, DNA gyrase subunit B, ...
Authors:Xu, Z.H, Zhou, Z.
Deposit date:2020-02-26
Release date:2020-09-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.254 Å)
Cite:Discovery of Pyrido[2,3-b]indole Derivatives with Gram-Negative Activity Targeting Both DNA Gyrase and Topoisomerase IV.
J.Med.Chem., 63, 2020
6LQD
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BU of 6lqd by Molmil
Structure of Enterovirus 71 in complex with NLD-22
Descriptor: 1-(2-azanylpyridin-4-yl)-3-[5-[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]pentyl]imidazolidin-2-one, Capsid protein VP1, Capsid protein VP2, ...
Authors:Zhang, M, Sun, Y, Wang, X, Guo, Y, Rao, Z.
Deposit date:2020-01-13
Release date:2020-03-11
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.264 Å)
Cite:Design, Synthesis, and Evaluation of Novel Enterovirus 71 Inhibitors as Therapeutic Drug Leads for the Treatment of Human Hand, Foot, and Mouth Disease.
J.Med.Chem., 63, 2020
8W44
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BU of 8w44 by Molmil
X-ray crystal structure of V30M-TTR in complex with oxyresveratrol
Descriptor: SODIUM ION, Transthyretin, trans-oxyresveratrol
Authors:Yokoyama, T.
Deposit date:2023-08-23
Release date:2023-11-22
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.399 Å)
Cite:Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin.
J.Med.Chem., 66, 2023
8W46
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BU of 8w46 by Molmil
X-ray crystal structure of V30M-TTR in complex with pterostilbene
Descriptor: Pterostilbene, SODIUM ION, Transthyretin
Authors:Yokoyama, T.
Deposit date:2023-08-23
Release date:2023-11-22
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin.
J.Med.Chem., 66, 2023
8W48
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BU of 8w48 by Molmil
Neutron and X-ray joint structure of WT-TTR in complex with piceatannol
Descriptor: PICEATANNOL, Transthyretin
Authors:Yokoyama, T, Kusaka, K, Fujiwara, S.
Deposit date:2023-08-23
Release date:2023-11-22
Last modified:2023-12-06
Method:NEUTRON DIFFRACTION (1.19 Å), X-RAY DIFFRACTION
Cite:Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin.
J.Med.Chem., 66, 2023
8W43
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BU of 8w43 by Molmil
X-ray crystal structure of V30M-TTR in complex with piceatannol
Descriptor: PICEATANNOL, SODIUM ION, Transthyretin
Authors:Yokoyama, T.
Deposit date:2023-08-23
Release date:2023-11-22
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.302 Å)
Cite:Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin.
J.Med.Chem., 66, 2023
8W45
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BU of 8w45 by Molmil
X-ray crystal structure of V30M-TTR in complex with pinostilbene
Descriptor: 3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxy-phenol, SODIUM ION, Transthyretin
Authors:Yokoyama, T.
Deposit date:2023-08-23
Release date:2023-11-22
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin.
J.Med.Chem., 66, 2023

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