7ZNG
| Crystal structure of the light-driven inward proton pump xenorhodopsin BcXeR in the ground state at pH 8.2 at room temperature, 500-mks-long snapshots | Descriptor: | EICOSANE, OLEIC ACID, PHOSPHATE ION, ... | Authors: | Kovalev, K, Tsybrov, F, Alekseev, A, Bourenkov, G, Gordeliy, V. | Deposit date: | 2022-04-20 | Release date: | 2023-05-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Mechanisms of inward transmembrane proton translocation. Nat.Struct.Mol.Biol., 30, 2023
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7ZNH
| Crystal structure of the light-driven inward proton pump xenorhodopsin BcXeR in the activated state at pH 8.2 at room temperature, 250-750-mks-snapshot | Descriptor: | EICOSANE, OLEIC ACID, PHOSPHATE ION, ... | Authors: | Kovalev, K, Tsybrov, F, Alekseev, A, Bourenkov, G, Gordeliy, V. | Deposit date: | 2022-04-20 | Release date: | 2023-05-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Mechanisms of inward transmembrane proton translocation. Nat.Struct.Mol.Biol., 30, 2023
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7ZNI
| Crystal structure of the light-driven inward proton pump xenorhodopsin BcXeR in the activated state at pH 8.2 at room temperature, 7.5-15-ms-snapshot | Descriptor: | EICOSANE, OLEIC ACID, PHOSPHATE ION, ... | Authors: | Kovalev, K, Tsybrov, F, Alekseev, A, Bourenkov, G, Gordeliy, V. | Deposit date: | 2022-04-20 | Release date: | 2023-05-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mechanisms of inward transmembrane proton translocation. Nat.Struct.Mol.Biol., 30, 2023
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7L4U
| Crystal structure of human monoacylglycerol lipase in complex with compound 1h | Descriptor: | (5S)-5-(3-{4-[(2-chloro-4-fluorophenoxy)methyl]piperidin-1-yl}-3-oxopropyl)pyrrolidin-2-one, CHLORIDE ION, Monoglyceride lipase | Authors: | Qin, L, Lane, W, Skene, R.J, Dougan, D. | Deposit date: | 2020-12-21 | Release date: | 2021-08-11 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2 H -benzo[ b ][1,4]oxazin-6-yl Moiety. J.Med.Chem., 64, 2021
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7L50
| Crystal structure of human monoacylglycerol lipase in complex with compound 4f | Descriptor: | (2s,4R)-2-{3-[(3-chloro-4-methylphenyl)methoxy]azetidine-1-carbonyl}-7-oxa-5-azaspiro[3.4]octan-6-one, ACETATE ION, Monoglyceride lipase | Authors: | Qin, L, Lane, W, Skene, R.J. | Deposit date: | 2020-12-21 | Release date: | 2021-08-11 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2 H -benzo[ b ][1,4]oxazin-6-yl Moiety. J.Med.Chem., 64, 2021
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7L4W
| Crystal structure of human monoacylglycerol lipase in complex with compound 2d | Descriptor: | (2s,4R)-2-{4-[(2-chloro-4-fluorophenoxy)methyl]piperidine-1-carbonyl}-7-oxa-5-azaspiro[3.4]octan-6-one, Monoglyceride lipase | Authors: | Qin, L, Gay, S.C, Lane, W, Skene, R.J. | Deposit date: | 2020-12-21 | Release date: | 2021-08-11 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2 H -benzo[ b ][1,4]oxazin-6-yl Moiety. J.Med.Chem., 64, 2021
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7L4T
| Crystal structure of human monoacylglycerol lipase in complex with compound 1 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 6-{4-[(2-chloro-4-fluorophenoxy)methyl]piperidine-1-carbonyl}-2H-1,4-benzoxazin-3(4H)-one, ACETATE ION, ... | Authors: | Qin, L, Gay, S.C, Lane, W, Skene, R.J. | Deposit date: | 2020-12-21 | Release date: | 2021-08-11 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2 H -benzo[ b ][1,4]oxazin-6-yl Moiety. J.Med.Chem., 64, 2021
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6RAZ
| D. melanogaster CMG-DNA, State 2B | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, AT18545p, ... | Authors: | Eickhoff, P, Martino, F, Costa, A. | Deposit date: | 2019-04-08 | Release date: | 2019-09-18 | Last modified: | 2021-01-20 | Method: | ELECTRON MICROSCOPY (4.46 Å) | Cite: | Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome. Cell Rep, 28, 2019
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6RAY
| D. melanogaster CMG-DNA, State 2A | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, AT18545p, ... | Authors: | Eickhoff, P, Martino, F, Costa, A. | Deposit date: | 2019-04-08 | Release date: | 2019-09-11 | Last modified: | 2019-09-18 | Method: | ELECTRON MICROSCOPY (4.28 Å) | Cite: | Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome. Cell Rep, 28, 2019
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7F5K
| Crystal structure of TCR4-1 ectodomain | Descriptor: | T cell receptor alpha chain, T cell receptor beta chain | Authors: | Nagae, M, Yamasaki, S. | Deposit date: | 2021-06-22 | Release date: | 2022-06-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.0000298 Å) | Cite: | Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b. Nat Commun, 13, 2022
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7F9F
| Thrombocorticin | Descriptor: | MAGNESIUM ION, Thrombocorticin | Authors: | Kageyama, H, Onodera, K, Sakai, R, Tanaka, Y, Freymann, D.M. | Deposit date: | 2021-07-04 | Release date: | 2022-07-06 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.411 Å) | Cite: | A marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation. Nat Commun, 13, 2022
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7F9G
| Thrombocorticin in complex with Ca2+ and fucose | Descriptor: | CALCIUM ION, Thrombocorticin, alpha-L-fucopyranose | Authors: | Kageyama, H, Onodera, K, Sakai, R, Tanaka, Y. | Deposit date: | 2021-07-04 | Release date: | 2022-07-06 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.331 Å) | Cite: | A marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation. Nat Commun, 13, 2022
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7F9J
| Thrombocorticin Q25K in complex with Ca2+ | Descriptor: | CALCIUM ION, Thrombocorticin Q25K mutant | Authors: | Kageyama, H, Onodera, K, Sakai, R, Tanaka, Y. | Deposit date: | 2021-07-04 | Release date: | 2022-07-06 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | A marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation. Nat Commun, 13, 2022
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7F91
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7FBL
| Thrombocorticin in complex with Ca2+ and mannose | Descriptor: | CALCIUM ION, Thrombocorticin, alpha-D-mannopyranose | Authors: | Kageyama, H, Onodera, K, Sakai, R, Tanaka, Y. | Deposit date: | 2021-07-11 | Release date: | 2022-07-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.419 Å) | Cite: | A marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation. Nat Commun, 13, 2022
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7LUB
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7U0Y
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6S8R
| D. melanogaster RNA helicase Me31B in complex with GIGYF | Descriptor: | ACETATE ION, ATP-dependent RNA helicase me31b, GIGYF family protein CG11148 | Authors: | Peter, D, Valkov, E. | Deposit date: | 2019-07-10 | Release date: | 2019-09-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated translational repression. Genes Dev., 33, 2019
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8QBT
| E. coli ApdP-stalled ribosomal complex | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S11, ... | Authors: | Morici, M, Wilson, D.N. | Deposit date: | 2023-08-25 | Release date: | 2024-03-20 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | RAPP-containing arrest peptides induce translational stalling by short circuiting the ribosomal peptidyltransferase activity. Nat Commun, 15, 2024
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8QCQ
| B. subtilis ApdA-stalled ribosomal complex | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Morici, M, Wilson, D.N. | Deposit date: | 2023-08-28 | Release date: | 2024-03-20 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | RAPP-containing arrest peptides induce translational stalling by short circuiting the ribosomal peptidyltransferase activity. Nat Commun, 15, 2024
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6S9R
| Crystal structure of SSDP from D. melanogaster | Descriptor: | Sequence-specific single-stranded DNA-binding protein, isoform A | Authors: | Renko, M, Bienz, M. | Deposit date: | 2019-07-15 | Release date: | 2019-10-09 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Rotational symmetry of the structured Chip/LDB-SSDP core module of the Wnt enhanceosome. Proc.Natl.Acad.Sci.USA, 116, 2019
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8BLR
| G13D mutant of KRAS4b (2-169) bound to GDP with the switch-I in fully open conformation | Descriptor: | GTPase KRas, N-terminally processed, GUANOSINE-5'-DIPHOSPHATE | Authors: | Moche, M, Jungholm, O, Strandback, E, Ampah-Korsah, H, Nyman, T, Orwar, O. | Deposit date: | 2022-11-10 | Release date: | 2024-05-22 | Last modified: | 2024-09-11 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Novel druggable space in human KRAS G13D discovered using structural bioinformatics and a P-loop targeting monoclonal antibody. Sci Rep, 14, 2024
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7MRZ
| Structure of GDF11 bound to fused ActRIIB-ECD and Alk4-ECD with Anti-ActRIIB Fab fragment | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2B,Activin receptor type-1B, Fab Heavy Chain, ... | Authors: | Goebel, E.J, Kattamuri, C, Gipson, G.R, Thompson, T.B. | Deposit date: | 2021-05-10 | Release date: | 2022-01-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures of activin ligand traps using natural sets of type I and type II TGF beta receptors. Iscience, 25, 2022
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7MEP
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7MDU
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