7LUB

Crystal structure of recombinant human fumarase in complex with D-2-amino-3-phosphono-propionic acid

Summary for 7LUB

• Entry DOI: 10.2210/pdb7lub/pdb
• Descriptor: Fumarate hydratase, mitochondrial, D-2-AMINO-3-PHOSPHONO-PROPIONIC ACID, GLYCEROL, ... (4 entities in total)
• Functional Keywords: fumarase, lyase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 100893.22

Authors

Cardoso, I.A.,Nonato, M.C. (deposition date: 2021-02-21, release date: 2022-02-23, Last modification date: 2023-10-25)

• Primary citation: Hicks, K.G.,Cluntun, A.A.,Schubert, H.L.,Hackett, S.R.,Berg, J.A.,Leonard, P.G.,Ajalla Aleixo, M.A.,Zhou, Y.,Bott, A.J.,Salvatore, S.R.,Chang, F.,Blevins, A.,Barta, P.,Tilley, S.,Leifer, A.,Guzman, A.,Arok, A.,Fogarty, S.,Winter, J.M.,Ahn, H.C.,Allen, K.N.,Block, S.,Cardoso, I.A.,Ding, J.,Dreveny, I.,Gasper, W.C.,Ho, Q.,Matsuura, A.,Palladino, M.J.,Prajapati, S.,Sun, P.,Tittmann, K.,Tolan, D.R.,Unterlass, J.,VanDemark, A.P.,Vander Heiden, M.G.,Webb, B.A.,Yun, C.H.,Zhao, P.,Wang, B.,Schopfer, F.J.,Hill, C.P.,Nonato, M.C.,Muller, F.L.,Cox, J.E.,Rutter, J.; Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase.; Science, 379:996-1003, 2023; PubMed: 36893255; DOI: 10.1126/science.abm3452

Experimental method

X-RAY DIFFRACTION (2.15 Å)