1N6P
 
 | | Crystal Structure of Human Rab5a A30E mutant complex with GppNHp | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-5A | | Authors: | Zhu, G, Liu, J, Terzyan, S, Zhai, P, Li, G, Zhang, X.C. | | Deposit date: | 2002-11-11 | | Release date: | 2002-11-27 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.54 Å) | | Cite: | High Resolution Crystal Structures of Human Rab5a and Five Mutants with Substitutions in the Catalytically Important Phosphate-Binding Loop
J.Biol.Chem., 278, 2003
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1N6R
 | | Crystal Structure of Human Rab5a A30L mutant complex with GppNHp | | Descriptor: | BETA-MERCAPTOETHANOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | Authors: | Zhu, G, Liu, J, Terzyan, S, Zhai, P, Li, G, Zhang, X.C. | | Deposit date: | 2002-11-11 | | Release date: | 2002-11-27 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | High Resolution Crystal Structures of Human Rab5a and Five Mutants with Substitutions in the Catalytically Important Phosphate-Binding Loop
J.Biol.Chem., 278, 2003
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5E95
 | | Crystal Structure of Mb(NS1)/H-Ras Complex | | Descriptor: | GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Eguchi, R.R, Sha, F, Gupta, A, Koide, A, Koide, S. | | Deposit date: | 2015-10-14 | | Release date: | 2016-11-02 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.402 Å) | | Cite: | Inhibition of RAS function through targeting an allosteric regulatory site.
Nat. Chem. Biol., 13, 2017
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2VH5
 | | CRYSTAL STRUCTURE OF HRAS(G12V) - ANTI-RAS FV (disulfide free mutant) COMPLEX | | Descriptor: | ANTI-RAS FV HEAVY CHAIN, ANTI-RAS FV LIGHT CHAIN, GTPASE HRAS, ... | | Authors: | Tanaka, T, Williams, R.L, Rabbitts, T.H. | | Deposit date: | 2007-11-19 | | Release date: | 2008-01-22 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Functional Intracellular Antibody Fragments Do not Require Invariant Intra-Domain Disulfide Bonds.
J.Mol.Biol., 376, 2008
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1OIV
 | | X-ray structure of the small G protein Rab11a in complex with GDP | | Descriptor: | 1,2-ETHANEDIOL, GUANOSINE-5'-DIPHOSPHATE, RAS-RELATED PROTEIN RAB-11A, ... | | Authors: | Pasqualato, S, Senic-Matuglia, F, Renault, L, Goud, B, Salamero, J, Cherfils, J. | | Deposit date: | 2003-06-26 | | Release date: | 2004-01-08 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | The Structural Gdp/GTP Cycle of Rab11 Reveals a Novel Interface Involved in the Dynamics of Recycling Endosomes
J.Biol.Chem., 279, 2004
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2DPX
 | | Crystal Structure of human Rad GTPase | | Descriptor: | GTP-binding protein RAD, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Yanuar, A, Sakurai, S, Kitano, K, Hakoshima, T. | | Deposit date: | 2006-05-18 | | Release date: | 2006-08-08 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of human Rad GTPase of the RGK-family
Genes Cells, 11, 2006
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3K9L
 | | Allosteric modulation of H-Ras GTPase | | Descriptor: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | Authors: | Fetics, S, Young, M, Buhrman, G, Mattos, C. | | Deposit date: | 2009-10-15 | | Release date: | 2010-11-03 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Allosteric modulation of H-Ras GTPase
To be Published
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2CLS
 | | The crystal structure of the human RND1 GTPase in the active GTP bound state | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RHO-RELATED GTP-BINDING PROTEIN RHO6 | | Authors: | Pike, A.C.W, Yang, X, Colebrook, S, Gileadi, O, Sobott, F, Bray, J, Wen Hwa, L, Marsden, B, Zhao, Y, Schoch, G, Elkins, J, Debreczeni, J.E, Turnbull, A.P, von Delft, F, Arrowsmith, C, Edwards, A, Weigelt, J, Sundstrom, M, Doyle, D. | | Deposit date: | 2006-04-28 | | Release date: | 2006-05-04 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | The Crystal Structure of the Human Rnd1 Gtpase in the Active GTP Bound State
To be Published
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2CLC
 | | CRYSTAL STRUCTURE ANALYSIS OF A FLUORESCENT FORM OF H-RAS P21 IN COMPLEX WITH GTP (2) | | Descriptor: | GTPASE HRAS, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Klink, B.U, Goody, R.S, Scheidig, A.J. | | Deposit date: | 2006-04-27 | | Release date: | 2006-05-24 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | A Newly Designed Microspectrofluorometer for Kinetic Studies on Protein Crystals in Combination with X-Ray Diffraction
Biophys.J., 91, 2006
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1M7B
 | | Crystal structure of Rnd3/RhoE: functional implications | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Rnd3/RhoE small GTP-binding protein | | Authors: | Fiegen, D, Blumenstein, L, Stege, P, Vetter, I.R, Ahmadian, M.R. | | Deposit date: | 2002-07-19 | | Release date: | 2002-08-07 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of Rnd3/RhoE: functional implications
FEBS LETT., 525, 2002
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3KKO
 | | Crystal structure of M-Ras P40D/D41E/L51R in complex with GppNHp | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein M-Ras, ... | | Authors: | Muraoka, S, Shima, F, Liao, J, Ijiri, Y, Matsumoto, K, Ye, M, Inoue, T, Kataoka, T. | | Deposit date: | 2009-11-06 | | Release date: | 2010-06-16 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis for conformational dynamics of GTP-bound Ras protein
J.Biol.Chem., 285, 2010
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3LAW
 | | Structure of GTP-bound L129F mutant Rab7 | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-7a | | Authors: | McCray, B.A, Skordalakes, E, Taylor, J.P. | | Deposit date: | 2010-01-07 | | Release date: | 2010-01-26 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation.
Hum.Mol.Genet., 19, 2010
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3LBN
 | | Ras soaked in Magnesium Acetate | | Descriptor: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | Authors: | Holzapfel, G, Buhrman, G, Mattos, C. | | Deposit date: | 2010-01-08 | | Release date: | 2010-03-02 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.862 Å) | | Cite: | Allosteric modulation of Ras positions Q61 for a direct role in catalysis.
Proc.Natl.Acad.Sci.USA, 107, 2010
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2W2X
 | | Complex of Rac2 and PLCg2 spPH Domain | | Descriptor: | 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H. | | Deposit date: | 2008-11-04 | | Release date: | 2009-05-05 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2.
Mol.Cell, 34, 2009
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1MH1
 | | SMALL G-PROTEIN | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, RAC1 | | Authors: | Hirshberg, M, Stockley, R.W, Dodson, G, Webb, M.R. | | Deposit date: | 1997-01-21 | | Release date: | 1998-01-21 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.38 Å) | | Cite: | The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue.
Nat.Struct.Biol., 4, 1997
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2BMD
 | | high resolution structure of GDP-bound human Rab4a | | Descriptor: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, RAS-RELATED PROTEIN RAB4A | | Authors: | Scheidig, A.J, Huber, S.K. | | Deposit date: | 2005-03-13 | | Release date: | 2005-04-25 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | High Resolution Crystal Structures of Human Rab4A in its Active and Inactive Conformations.
FEBS Lett., 579, 2005
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1P2S
 | | H-Ras 166 in 50% 2,2,2 triflouroethanol | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, TRIFLUOROETHANOL, ... | | Authors: | Buhrman, G.K, de Serrano, V, Mattos, C. | | Deposit date: | 2003-04-16 | | Release date: | 2003-08-05 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Organic Solvents Order the Dynamic Switch II in Ras Crystals
Structure, 11, 2003
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1P2T
 | | H-Ras 166 in Aqueous mother liqour, RT | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Transforming protein p21/H-RAS-1 | | Authors: | Buhrman, G.K, de Serrano, V, Mattos, C. | | Deposit date: | 2003-04-16 | | Release date: | 2003-08-05 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Organic solvents order the dynamic switch II in Ras crystals
Structure, 11, 2003
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1P2U
 | | H-Ras in 50% isopropanol | | Descriptor: | ISOPROPYL ALCOHOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | Authors: | Buhrman, G.K, de Serrano, V, Mattos, C. | | Deposit date: | 2003-04-16 | | Release date: | 2003-08-05 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Organic solvents order the dynamic switch II in Ras crystals
Structure, 11, 2003
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2ASE
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1OIW
 | | X-ray structure of the small G protein Rab11a in complex with GTPgammaS | | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, RAS-RELATED PROTEIN RAB-11A | | Authors: | Pasqualato, S, Senic-Matuglia, F, Renault, L, Goud, B, Salamero, J, Cherfils, J. | | Deposit date: | 2003-06-26 | | Release date: | 2004-01-08 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | The Structural Gdp/GTP Cycle of Rab11 Reveals a Novel Interface Involved in the Dynamics of Recycling Endosomes
J.Biol.Chem., 279, 2004
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1OIX
 | | X-ray structure of the small G protein Rab11a in complex with GDP and Pi | | Descriptor: | CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Pasqualato, S, Senic-Matuglia, F, Renault, L, Goud, B, Salamero, J, Cherfils, J. | | Deposit date: | 2003-06-26 | | Release date: | 2005-01-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystallographic Evidence for Substrate-Assisted GTP Hydrolysis by a Small GTP Binding Protein
Structure, 13, 2005
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2W2T
 | | Rac2 (G12V) in complex with GDP | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2 | | Authors: | Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H. | | Deposit date: | 2008-11-04 | | Release date: | 2009-05-05 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2.
Mol.Cell, 34, 2009
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2RAP
 | | THE SMALL G PROTEIN RAP2A IN COMPLEX WITH GTP | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RAP2A | | Authors: | Cherfils, J, Menetrey, J, Lebras, G. | | Deposit date: | 1998-05-06 | | Release date: | 1998-06-17 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS.
EMBO J., 16, 1997
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2W2V
 | | Rac2 (G12V) in complex with GTPgS | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2 | | Authors: | Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H. | | Deposit date: | 2008-11-04 | | Release date: | 2009-05-05 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2.
Mol.Cell, 34, 2009
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