7R1O
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![BU of 7r1o by Molmil](/molmil-images/mine/7r1o) | p62-ZZ domain of the human sequestosome in complex with dusquetide | Descriptor: | Dusquetide, Sequestosome-1, ZINC ION | Authors: | Hakansson, M, Hansson, M, Logan, D.T, Rozek, A, Donini, O. | Deposit date: | 2022-02-03 | Release date: | 2022-05-18 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.202 Å) | Cite: | Dusquetide modulates innate immune response through binding to p62. Structure, 30, 2022
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4NZD
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![BU of 4nzd by Molmil](/molmil-images/mine/4nzd) | Interleukin 21 receptor | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Interleukin-21 receptor, ... | Authors: | Hamming, O.T, Kang, L, Siupka, P, Gad, H.H, Hartmann, R. | Deposit date: | 2013-12-12 | Release date: | 2014-12-17 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Interleukin 21 receptor structure and function To be Published
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4NWC
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![BU of 4nwc by Molmil](/molmil-images/mine/4nwc) | Crystal structure of the GluK3 ligand-binding domain (S1S2) in complex with the agonist (2S,4R)-4-(3-Methoxy-3-oxopropyl)glutamic acid at 2.01 A resolution. | Descriptor: | (2S,4R)-4-(3-Methoxy-3-oxopropyl) glutamic acid, CHLORIDE ION, Glutamate receptor ionotropic, ... | Authors: | Larsen, A.P, Venskutonyte, R, Frydenvang, K, Gajhede, M, Kastrup, J.S. | Deposit date: | 2013-12-06 | Release date: | 2014-08-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.012 Å) | Cite: | Molecular Recognition of Two 2,4-syn-Functionalized (S)-Glutamate Analogues by the Kainate Receptor GluK3 Ligand Binding Domain. Chemmedchem, 9, 2014
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4NZB
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![BU of 4nzb by Molmil](/molmil-images/mine/4nzb) | NS9283 bound to Ls-AChBP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl]benzonitrile, ACETATE ION, ... | Authors: | Olsen, J.A, Kastrup, J.S, Gajhede, M. | Deposit date: | 2013-12-11 | Release date: | 2014-07-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at alpha 4 beta 2 nicotinic acetylcholine receptors. J.Biol.Chem., 289, 2014
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4O3A
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![BU of 4o3a by Molmil](/molmil-images/mine/4o3a) | Crystal structure of the glua2 ligand-binding domain in complex with L-aspartate at 1.80 a resolution | Descriptor: | ACETATE ION, ASPARTIC ACID, CHLORIDE ION, ... | Authors: | Krintel, C, Frydenvang, F, Gajhede, M, Kastrup, J.S. | Deposit date: | 2013-12-18 | Release date: | 2014-04-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. Febs J., 281, 2014
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4O3B
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![BU of 4o3b by Molmil](/molmil-images/mine/4o3b) | Crystal structure of an open/closed glua2 ligand-binding domain dimer at 1.91 A resolution | Descriptor: | ACETATE ION, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Krintel, C, de Rabassa, A.C, Frydenvang, K, Gajhede, M, Kastrup, J.S. | Deposit date: | 2013-12-18 | Release date: | 2014-04-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.906 Å) | Cite: | L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. Febs J., 281, 2014
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4O3C
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![BU of 4o3c by Molmil](/molmil-images/mine/4o3c) | Crystal structure of the GLUA2 ligand-binding domain in complex with L-aspartate at 1.50 A resolution | Descriptor: | ACETATE ION, ASPARTIC ACID, CHLORIDE ION, ... | Authors: | Krintel, C, Frydenvang, K, Kaern, A.M, Gajhede, M, Kastrup, J.S. | Deposit date: | 2013-12-18 | Release date: | 2014-04-16 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. Febs J., 281, 2014
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4LP4
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![BU of 4lp4 by Molmil](/molmil-images/mine/4lp4) | |
3EII
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![BU of 3eii by Molmil](/molmil-images/mine/3eii) | Zinc-bound glycoside hydrolase 61 E from Thielavia terrestris | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, SULFATE ION, ... | Authors: | Salbo, R, Welner, D, Lo Leggio, L, Harris, P, McFarland, K. | Deposit date: | 2008-09-16 | Release date: | 2009-10-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Stimulation of lignocellulosic biomass hydrolysis by proteins of glycoside hydrolase family 61: structure and function of a large, enigmatic family. Biochemistry, 49, 2010
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4M4M
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![BU of 4m4m by Molmil](/molmil-images/mine/4m4m) | The structure of Ni T6 bovine insulin | Descriptor: | Insulin, NICKEL (II) ION | Authors: | Frankaer, C.G, Harris, P, Stahl, K. | Deposit date: | 2013-08-07 | Release date: | 2014-01-15 | Last modified: | 2018-03-07 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Towards accurate structural characterization of metal centres in protein crystals: the structures of Ni and Cu T6 bovine insulin derivatives. Acta Crystallogr.,Sect.D, 70, 2014
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2PKD
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![BU of 2pkd by Molmil](/molmil-images/mine/2pkd) | Crystal structure of CD84: Insite into SLAM family function | Descriptor: | CHLORIDE ION, SLAM family member 5 | Authors: | Yan, Q, Malashkevich, V.N, Fedorov, A, Cao, E, Lary, J.W, Cole, J.L, Nathenson, S.G, Almo, S.C. | Deposit date: | 2007-04-17 | Release date: | 2007-06-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.043 Å) | Cite: | Structure of CD84 provides insight into SLAM family function. Proc.Natl.Acad.Sci.Usa, 104, 2007
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4P3B
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2OZQ
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![BU of 2ozq by Molmil](/molmil-images/mine/2ozq) | Crystal Structure of apo-MUP | Descriptor: | CADMIUM ION, Novel member of the major urinary protein (Mup) gene family, SODIUM ION | Authors: | Dennis, C.A, Homans, S.W, Phillips, S.E.V, Syme, N.R. | Deposit date: | 2007-02-27 | Release date: | 2008-01-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Origin of heat capacity changes in a "nonclassical" hydrophobic interaction. Chembiochem, 8, 2007
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4P3A
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4PC3
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![BU of 4pc3 by Molmil](/molmil-images/mine/4pc3) | Elongation factor Tu:Ts complex with partially bound GDP | Descriptor: | Elongation factor Ts, Elongation factor Tu 1, GLYCEROL, ... | Authors: | Thirup, S.S. | Deposit date: | 2014-04-14 | Release date: | 2015-05-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8313 Å) | Cite: | Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu. J.Struct.Biol., 191, 2015
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4P2Y
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![BU of 4p2y by Molmil](/molmil-images/mine/4p2y) | |
4PC7
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![BU of 4pc7 by Molmil](/molmil-images/mine/4pc7) | Elongation factor Tu:Ts complex in a near GTP conformation. | Descriptor: | (1S,2S,3E,5E,7E,10S,11S,12S)-12-[(2R,4E,6E,8Z,10R,12E,14E,16Z,18S,19Z)-10,18-DIHYDROXY-12,16,19-TRIMETHYL-11,22-DIOXOOX ACYCLODOCOSA-4,6,8,12,14,16,19-HEPTAEN-2-YL]-2,11-DIHYDROXY-1,10-DIMETHYL-9-OXOTRIDECA-3,5,7-TRIEN-1-YL 6-DEOXY-2,4-DI-O-METHYL-BETA-L-GALACTOPYRANOSIDE, Elongation factor Ts, Elongation factor Tu 1, ... | Authors: | Thirup, S.S. | Deposit date: | 2014-04-14 | Release date: | 2015-05-06 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.6003 Å) | Cite: | Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu. J.Struct.Biol., 191, 2015
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2NPQ
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2QFW
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![BU of 2qfw by Molmil](/molmil-images/mine/2qfw) | |
3VM5
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![BU of 3vm5 by Molmil](/molmil-images/mine/3vm5) | |
3MPT
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![BU of 3mpt by Molmil](/molmil-images/mine/3mpt) | Crystal structure of P38 kinase in complex with a pyrrole-2-carboxamide inhibitor | Descriptor: | GLYCEROL, Mitogen-activated protein kinase 14, N-(furan-2-ylmethyl)-4-[(2-methylphenyl)carbonyl]-1H-pyrrole-2-carboxamide | Authors: | Somers, D.O. | Deposit date: | 2010-04-27 | Release date: | 2010-07-07 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | The discovery and initial optimisation of pyrrole-2-carboxamides as inhibitors of p38alpha MAP kinase. Bioorg.Med.Chem.Lett., 20, 2010
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3NNU
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![BU of 3nnu by Molmil](/molmil-images/mine/3nnu) | Crystal structure of P38 alpha in complex with DP1376 | Descriptor: | 2-{3-[(5E)-5-{[(2,3-dichlorophenyl)carbamoyl]imino}-3-thiophen-2-yl-2,5-dihydro-1H-pyrazol-1-yl]phenyl}acetamide, Mitogen-activated protein kinase 14 | Authors: | Abendroth, J. | Deposit date: | 2010-06-24 | Release date: | 2010-09-15 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region Bioorg.Med.Chem.Lett., 20, 2010
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3NNW
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![BU of 3nnw by Molmil](/molmil-images/mine/3nnw) | Crystal structure of P38 alpha in complex with DP802 | Descriptor: | 2-[3-(3-tert-butyl-5-{[(2,3-dichlorophenyl)carbamoyl]imino}-2,5-dihydro-1H-pyrazol-1-yl)phenyl]acetamide, Mitogen-activated protein kinase 14 | Authors: | Abendroth, J. | Deposit date: | 2010-06-24 | Release date: | 2010-09-15 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region Bioorg.Med.Chem.Lett., 20, 2010
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3MW1
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![BU of 3mw1 by Molmil](/molmil-images/mine/3mw1) | p38 kinase Crystal structure in complex with small molecule inhibitor | Descriptor: | 8-(2,6-dichlorophenyl)-4-(2,4-difluorophenyl)-2-piperidin-4-yl-1,7-naphthyridine 7-oxide, Mitogen-activated protein kinase 14 | Authors: | Segarra, V, Caturla, F, Lumeras, W, Roca, R, Fisher, M, Lamers, M. | Deposit date: | 2010-05-05 | Release date: | 2011-04-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | 1,7-Naphthyridine 1-Oxides as Novel Potent and Selective Inhibitors of p38 Mitogen Activated Protein Kinase J.Med.Chem., 54, 2011
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3QB4
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![BU of 3qb4 by Molmil](/molmil-images/mine/3qb4) | |