PDB: 46984 resultsInfo pagesStatus searchChemie searchBIRD

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6YMO	Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pS617 peptide Descriptor: 14-3-3 protein zeta/delta, 2-HYDROXYBENZOIC ACID, Glucocorticoid receptor, ... Authors: Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. Deposit date: 2020-04-09 Release date: 2021-03-24 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
7NIF	14-3-3 sigma with Pin1 binding site pS72 and covalently bound TCF521-011 Descriptor: 1-(4-methylphenyl)imidazole, 14-3-3 protein sigma, CALCIUM ION, ... Authors: Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. Deposit date: 2021-02-12 Release date: 2021-06-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
3O8I	Structure of 14-3-3 isoform sigma in complex with a C-Raf1 peptide and a stabilizing small molecule fragment Descriptor: 14-3-3 binding site peptide of RAF proto-oncogene serine/threonine-protein kinase, 14-3-3 protein sigma, 6,6-dihydroxy-1-methoxyhexan-2-one Authors: Ottmann, C, Rose, R, Kaiser, M, Kuhenne, P. Deposit date: 2010-08-03 Release date: 2010-09-29 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling Mol.Cell.Biol., 30, 2010
7D8P	CRTC1 pSer151 peptide in complex with 14-3-3 zeta Descriptor: 14-3-3 protein zeta/delta, CRTC1 pSer151 peptide, GLYCEROL Authors: Chen, H, Zhang, H, Xiang, S. Deposit date: 2020-10-08 Release date: 2021-02-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol., 433, 2021
3RDH	X-ray induced covalent inhibition of 14-3-3 Descriptor: 14-3-3 protein zeta/delta, 4-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]benzoic acid, NICKEL (II) ION Authors: Horton, J.R, Upadhyay, A.K, Fu, H, Cheng, X. Deposit date: 2011-04-01 Release date: 2011-09-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor. Proc.Natl.Acad.Sci.USA, 108, 2011
4DAT	Structure of 14-3-3 sigma in complex with PADI6 14-3-3 binding motif II Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, Peptidylarginine Deiminase type VI Authors: Rose, R, Rose, M, Ottmann, C. Deposit date: 2012-01-13 Release date: 2012-06-13 Last modified: 2012-10-24 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI. J.Struct.Biol., 180, 2012
6T5F	Human 14-3-3 sigma fused to the StARD1 peptide including phosphoserine-195 Descriptor: 14-3-3 protein sigma, StARD1 peptide Authors: Sluchanko, N.N, Tugaeva, K.V, Titterington, J, Antson, A.A. Deposit date: 2019-10-16 Release date: 2020-11-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.63 Å) Cite: Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14-3-3 protein family. Febs J., 287, 2020
8EC0	III2IV respiratory supercomplex from Saccharomyces cerevisiae cardiolipin-lacking mutant Descriptor: (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 5-(3,7,11,15,19,23-HEXAMETHYL-TETRACOSA-2,6,10,14,18,22-HEXAENYL)-2,3-DIMETHOXY-6-METHYL-BENZENE-1,4-DIOL, ... Authors: Hryc, C.F, Mileykovskaya, E, Baker, M, Dowhan, W. Deposit date: 2022-08-31 Release date: 2023-05-24 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structural insights into cardiolipin replacement by phosphatidylglycerol in a cardiolipin-lacking yeast respiratory supercomplex. Nat Commun, 14, 2023
8E7S	III2IV2 respiratory supercomplex from Saccharomyces cerevisiae with 4 bound UQ6 Descriptor: (5S,11R)-5,8,11-trihydroxy-5,11-dioxido-17-oxo-4,6,10,12,16-pentaoxa-5,11-diphosphaoctadec-1-yl pentadecanoate, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 5-(3,7,11,15,19,23-HEXAMETHYL-TETRACOSA-2,6,10,14,18,22-HEXAENYL)-2,3-DIMETHOXY-6-METHYL-BENZENE-1,4-DIOL, ... Authors: Hryc, C.F, Mileykovskaya, E, Baker, M, Dowhan, W. Deposit date: 2022-08-24 Release date: 2023-05-24 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural insights into cardiolipin replacement by phosphatidylglycerol in a cardiolipin-lacking yeast respiratory supercomplex. Nat Commun, 14, 2023
7D9V	CRTC1 pSer245 peptide in complex with 14-3-3 zeta Descriptor: 14-3-3 protein zeta/delta, CRTC1 pSer245 peptide, GLYCEROL Authors: Chen, H, Zhang, H, Xiang, S. Deposit date: 2020-10-14 Release date: 2021-02-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.21 Å) Cite: Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol., 433, 2021
7D8H	CRTC1 pSer64 peptide in complex with 14-3-3 zeta Descriptor: 14-3-3 protein zeta/delta, CRTC1 pSer64 peptide Authors: Chen, H, Zhang, H, Xiang, S. Deposit date: 2020-10-08 Release date: 2021-02-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.42 Å) Cite: Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol., 433, 2021
7NND	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 09 Descriptor: 14-3-3 protein sigma, 5-[1-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-24 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NMX	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 12 Descriptor: 14-3-3 protein sigma, Amot-p130 phosphopeptide (pS175), CALCIUM ION, ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-23 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NPG	Crystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide and fragment 22 Descriptor: 14-3-3 protein sigma, 5-[3-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-26 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.37 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NMW	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 40 Descriptor: 14-3-3 protein sigma, 5-(2-azanylethyl)-4-phenyl-thiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-23 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NNE	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 22 Descriptor: 14-3-3 protein sigma, 5-[3-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-24 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NPB	Crystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide and fragment 09 Descriptor: 14-3-3 protein sigma, 5-[1-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-26 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.37 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NMA	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide Descriptor: 14-3-3 protein sigma, Amot-p130 phosphopeptide (pS175), CHLORIDE ION, ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-23 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NN2	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 41 Descriptor: 14-3-3 protein sigma, 7-(6-azanyl-5-methyl-pyridin-2-yl)-1-benzothiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-24 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NP2	Crystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide Descriptor: 14-3-3 protein sigma, Amot-p130 phosphopeptide (pS175), CHLORIDE ION, ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-26 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.27 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
5OMA	CH3 chimera of human 14-3-3 sigma with the StARD1 peptide including Ser57 Descriptor: 14-3-3 protein sigma,Steroidogenic acute regulatory protein, mitochondrial, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... Authors: Sluchanko, N.N, Tugaeva, K.V, Greive, S.J, Antson, A.A. Deposit date: 2017-07-28 Release date: 2017-10-11 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.9 Å) Cite: Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners. Sci Rep, 7, 2017
7BMC	Crystal structure of 14-3-3 sigma in complex with CIP2ApS904 peptide and stabilizing Fusicoccin A Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-01-19 Release date: 2022-03-02 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2 Å) Cite: Fusicoccin-A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C-Terminal Interaction with 14-3-3. Acs Chem.Biol., 17, 2022
7BM9	Crystal structure of 14-3-3 sigma in complex with CIP2ApS904 peptide Descriptor: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-01-19 Release date: 2022-03-02 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Fusicoccin-A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C-Terminal Interaction with 14-3-3. Acs Chem.Biol., 17, 2022
3T0L	Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening Descriptor: 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ... Authors: Thiel, P, Ottmann, C. Deposit date: 2011-07-20 Release date: 2012-12-26 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
6T5H	Human 14-3-3 sigma fused to the StARD1 peptide including phosphoserine-57 Descriptor: 14-3-3 protein sigma,Steroidogenic acute regulatory protein, mitochondrial, IMIDAZOLE, ... Authors: Sluchanko, N.N, Tugaeva, K.V, Titterington, J, Antson, A.A. Deposit date: 2019-10-16 Release date: 2020-11-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14-3-3 protein family. Febs J., 287, 2020

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