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2FNK
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BU of 2fnk by Molmil
Activation of Human Carbonic Anhydrase II by exogenous proton donors
Descriptor: Carbonic anhydrase 2, ZINC ION
Authors:Bhatt, D, Fisher, S.Z, Tu, C, McKenna, R, Silverman, D.N.
Deposit date:2006-01-11
Release date:2006-11-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Location of binding sites in small molecule rescue of human carbonic anhydrase II.
Biophys.J., 92, 2007
1Z93
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BU of 1z93 by Molmil
Human Carbonic Anhydrase III:Structural and Kinetic study of Catalysis and Proton Transfer.
Descriptor: Carbonic anhydrase III, ZINC ION
Authors:Duda, D.M, Tu, C, Fisher, S.Z, An, H, Yoshioka, C, Govindasamy, L, Laipis, P.J, Agbandje-McKenna, M, Silverman, D.N, McKenna, R.
Deposit date:2005-03-31
Release date:2005-08-09
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human Carbonic Anhydrase III: Structural and Kinetic Study of Catalysis and Proton Transfer
Biochemistry, 44, 2005
4HF3
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BU of 4hf3 by Molmil
Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
Descriptor: Carbonic anhydrase 2, IMIDAZOLE, ZINC ION
Authors:Aggarwal, M, McKenna, R.
Deposit date:2012-10-04
Release date:2013-10-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.1476 Å)
Cite:Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles.
IUCrJ, 1, 2014
6CA2
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BU of 6ca2 by Molmil
ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II
Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION
Authors:Alexander, R.S, Christianson, D.W.
Deposit date:1991-07-09
Release date:1992-07-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Engineering the hydrophobic pocket of carbonic anhydrase II.
Biochemistry, 30, 1991
4E3G
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BU of 4e3g by Molmil
Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
Descriptor: Carbonic anhydrase 2, GLYCEROL, MERCURIBENZOIC ACID, ...
Authors:Cohen, S.M, Martin, D.P.
Deposit date:2012-03-09
Release date:2012-06-27
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
Chem.Commun.(Camb.), 48, 2012
4E3H
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BU of 4e3h by Molmil
Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
Descriptor: Carbonic anhydrase 2, MERCURIBENZOIC ACID, ZINC ION, ...
Authors:Cohen, S.M, Martin, D.P.
Deposit date:2012-03-09
Release date:2012-06-27
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
Chem.Commun.(Camb.), 48, 2012
7PRI
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BU of 7pri by Molmil
Carbonic Anhydrase from Schistosoma Mansoni in complex with clorsulon
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-azanyl-6-[1,2,2-tris(chloranyl)ethenyl]benzene-1,3-disulfonamide, Carbonic anhydrase, ...
Authors:Angeli, A, Ferraroni, M.
Deposit date:2021-09-21
Release date:2022-10-05
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.679 Å)
Cite:Inhibition of Schistosoma mansoni carbonic anhydrase by the antiparasitic drug clorsulon: X-ray crystallographic and in vitro studies.
Acta Crystallogr D Struct Biol, 78, 2022
2HFW
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BU of 2hfw by Molmil
Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III
Descriptor: Carbonic anhydrase 3, ZINC ION
Authors:Elder, I, Fisher, S.Z, Laipis, P.J, Tu, C.K, McKenna, R, Silverman, D.N.
Deposit date:2006-06-26
Release date:2007-05-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III.
Proteins, 68, 2007
2IT4
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BU of 2it4 by Molmil
X ray structure of the complex between Carbonic Anhydrase I and the phosphonate antiviral drug foscarnet
Descriptor: Carbonic anhydrase 1, PHOSPHONOFORMIC ACID, ZINC ION
Authors:Temperini, C, Innocenti, A, Guerri, A, Scozzafava, A, Supuran, C.T.
Deposit date:2006-10-19
Release date:2007-09-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.
Bioorg.Med.Chem.Lett., 17, 2007
4E49
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BU of 4e49 by Molmil
Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
Descriptor: Carbonic anhydrase 2, MERCURIBENZOIC ACID, RESORCINOL, ...
Authors:Cohen, S.M, Martin, D.P.
Deposit date:2012-03-12
Release date:2012-06-27
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
Chem.Commun.(Camb.), 48, 2012
1YDC
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BU of 1ydc by Molmil
STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II
Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION
Authors:Nair, S.K, Christianson, D.W.
Deposit date:1994-12-22
Release date:1995-02-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis of inhibitor affinity to variants of human carbonic anhydrase II.
Biochemistry, 34, 1995
7CXY
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BU of 7cxy by Molmil
Structural insights into novel mechanisms of inhibition of the major b-carbonic anhydrase CafB from the pathogenic fungus Aspergillus fumigatus (zinc-bound form)
Descriptor: Carbonic anhydrase, ZINC ION
Authors:Jin, M.S, Kim, S, Yeon, J, Sung, J, Kim, N.J, Hong, S.
Deposit date:2020-09-02
Release date:2021-03-31
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural insights into novel mechanisms of inhibition of the major beta-carbonic anhydrase CafB from the pathogenic fungus Aspergillus fumigatus.
J.Struct.Biol., 213, 2021
2FOQ
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BU of 2foq by Molmil
Human Carbonic Anhydrase II complexed with two-prong inhibitors
Descriptor: Carbonic anhydrase 2, GLYCEROL, ZINC ION, ...
Authors:Jude, K.M, Christianson, D.W.
Deposit date:2006-01-13
Release date:2006-02-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity.
J.Am.Chem.Soc., 128, 2006
2FOY
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BU of 2foy by Molmil
Human Carbonic Anhydrase I complexed with a two-prong inhibitor
Descriptor: Carbonic anhydrase 1, ZINC ION, {2,2'-[(2-{[4-(AMINOSULFONYL)BENZOYL]AMINO}ETHYL)IMINO]DIACETATO(2-)-KAPPAO}COPPER
Authors:Jude, K.M, Banerjee, A.L, Haldar, M.K, Manokaran, S, Roy, B, Mallik, S, Srivastava, D.K, Christianson, D.W.
Deposit date:2006-01-14
Release date:2006-04-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity.
J.Am.Chem.Soc., 128, 2006
7C5W
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BU of 7c5w by Molmil
Crystal structure of the iota-carbonic anhydrase from cyanobacterium complexed with iodide
Descriptor: IODIDE ION, iota-carbonic anhydrase
Authors:Senda, M, Senda, T.
Deposit date:2020-05-20
Release date:2021-04-28
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Characterization of a novel type of carbonic anhydrase that acts without metal cofactors.
Bmc Biol., 19, 2021
7C5Y
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BU of 7c5y by Molmil
Crystal structure of the iota-carbonic anhydrase from eukaryotic microalga complexed with iodide
Descriptor: IODIDE ION, iota-carbonic anhydrase
Authors:Senda, M, Senda, T.
Deposit date:2020-05-20
Release date:2021-04-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Characterization of a novel type of carbonic anhydrase that acts without metal cofactors.
Bmc Biol., 19, 2021
7C5X
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BU of 7c5x by Molmil
Crystal structure of the iota-carbonic anhydrase from eukaryotic microalga complexed with bicarbonate
Descriptor: BICARBONATE ION, iota-carbonic anhydrase
Authors:Senda, M, Senda, T.
Deposit date:2020-05-20
Release date:2021-04-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Characterization of a novel type of carbonic anhydrase that acts without metal cofactors.
Bmc Biol., 19, 2021
7C5V
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BU of 7c5v by Molmil
Crystal structure of the iota-carbonic anhydrase from cyanobacterium complexed with bicarbonate
Descriptor: BICARBONATE ION, iota-carbonic anhydrase
Authors:Senda, M, Senda, T.
Deposit date:2020-05-20
Release date:2021-04-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Characterization of a novel type of carbonic anhydrase that acts without metal cofactors.
Bmc Biol., 19, 2021
7CA2
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BU of 7ca2 by Molmil
ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II
Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION
Authors:Nair, S.K, Christianson, D.W.
Deposit date:1991-07-09
Release date:1992-07-15
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Engineering the hydrophobic pocket of carbonic anhydrase II.
Biochemistry, 30, 1991
4O1J
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BU of 4o1j by Molmil
Crystal structures of two tetrameric beta-carbonic anhydrases from the filamentous ascomycete Sordaria macrospora.
Descriptor: CHLORIDE ION, Carbonic anhydrase, ZINC ION
Authors:Lehneck, R, Neumann, P, Vullo, D, Elleuche, S, Supuran, C.T, Ficner, R, Poggeler, S.
Deposit date:2013-12-16
Release date:2014-03-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.695 Å)
Cite:Crystal structures of two tetrameric beta-carbonic anhydrases from the filamentous ascomycete Sordaria macrospora.
Febs J., 281, 2014
3E24
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BU of 3e24 by Molmil
H. influenzae beta-carbonic anhydrase, variant W39F
Descriptor: Carbonic anhydrase 2, PHOSPHATE ION, ZINC ION
Authors:Rowlett, R.S, Lee, J.
Deposit date:2008-08-05
Release date:2009-06-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Allosteric site variants of Haemophilus influenzae beta-carbonic anhydrase.
Biochemistry, 48, 2009
3E28
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BU of 3e28 by Molmil
H. influenzae beta-carbonic anhydrase, variant Y181F
Descriptor: Carbonic anhydrase 2, SULFATE ION, ZINC ION
Authors:Rowlett, R.S, Lee, J.
Deposit date:2008-08-05
Release date:2009-06-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Allosteric site variants of Haemophilus influenzae beta-carbonic anhydrase.
Biochemistry, 48, 2009
3E1V
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BU of 3e1v by Molmil
H. influenzae beta-carbonic anhydrase, variant D44N
Descriptor: Carbonic anhydrase 2, ZINC ION
Authors:Rowlett, R.S, Chapnick, D.A, Shah, S.
Deposit date:2008-08-04
Release date:2009-06-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Allosteric site variants of Haemophilus influenzae beta-carbonic anhydrase.
Biochemistry, 48, 2009
3E1W
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BU of 3e1w by Molmil
H. influenzae beta-carbonic anhydrase, variant D44N in 100 mM sodium bicarbonate
Descriptor: Carbonic anhydrase 2, ZINC ION
Authors:Rowlett, R.S.
Deposit date:2008-08-04
Release date:2009-06-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Allosteric site variants of Haemophilus influenzae beta-carbonic anhydrase.
Biochemistry, 48, 2009
6JQC
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BU of 6jqc by Molmil
The structural basis of the beta-carbonic anhydrase CafC (wild type) of the filamentous fungus Aspergillus fumigatus
Descriptor: Carbonic anhydrase, ZINC ION
Authors:Jin, M.S, Kim, S, Kim, N.J, Hong, S, Kim, S, Sung, J.
Deposit date:2019-03-30
Release date:2019-08-14
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structural basis of the low catalytic activities of the two minor beta-carbonic anhydrases of the filamentous fungus Aspergillus fumigatus.
J.Struct.Biol., 208, 2019

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