7YID
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![BU of 7yid by Molmil](/molmil-images/mine/7yid) | Human KCNH5 closed state 1 | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | Authors: | Zhang, M.F. | Deposit date: | 2022-07-16 | Release date: | 2023-04-05 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel. Nat Commun, 14, 2023
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7YIH
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![BU of 7yih by Molmil](/molmil-images/mine/7yih) | Human KCNH5 open state | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | Authors: | Zhang, M.F. | Deposit date: | 2022-07-16 | Release date: | 2023-04-05 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel. Nat Commun, 14, 2023
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7YIJ
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![BU of 7yij by Molmil](/molmil-images/mine/7yij) | Human KCNH5 pore dilation but the non-conducting state | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | Authors: | Zhang, M.F. | Deposit date: | 2022-07-16 | Release date: | 2023-04-05 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel. Nat Commun, 14, 2023
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7YIF
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![BU of 7yif by Molmil](/molmil-images/mine/7yif) | Human KCNH5 pre-open state 1 | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | Authors: | Zhang, M.F. | Deposit date: | 2022-07-16 | Release date: | 2023-04-05 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel. Nat Commun, 14, 2023
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7YIG
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![BU of 7yig by Molmil](/molmil-images/mine/7yig) | Human KCNH5 pre-open state 2 | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | Authors: | Zhang, M.F. | Deposit date: | 2022-07-16 | Release date: | 2023-04-05 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel. Nat Commun, 14, 2023
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7YIE
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![BU of 7yie by Molmil](/molmil-images/mine/7yie) | Human KCNH5-closed state 2 | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | Authors: | Zhang, M.F. | Deposit date: | 2022-07-16 | Release date: | 2023-04-05 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel. Nat Commun, 14, 2023
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8PD8
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![BU of 8pd8 by Molmil](/molmil-images/mine/8pd8) | cAMP-bound SpSLC9C1 in lipid nanodiscs, dimer | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Sperm-specific sodium proton exchanger | Authors: | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | Deposit date: | 2023-06-12 | Release date: | 2023-11-08 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structures of a sperm-specific solute carrier gated by voltage and cAMP. Nature, 623, 2023
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8PD3
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![BU of 8pd3 by Molmil](/molmil-images/mine/8pd3) | Ligand-free SpSLC9C1 in lipid nanodiscs, protomer state 2 | Descriptor: | Sperm-specific sodium proton exchanger | Authors: | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | Deposit date: | 2023-06-11 | Release date: | 2023-11-08 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structures of a sperm-specific solute carrier gated by voltage and cAMP. Nature, 623, 2023
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8PCZ
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![BU of 8pcz by Molmil](/molmil-images/mine/8pcz) | Ligand-free SpSLC9C1 in lipid nanodiscs, dimer | Descriptor: | Sperm-specific sodium proton exchanger | Authors: | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | Deposit date: | 2023-06-11 | Release date: | 2023-11-08 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Structures of a sperm-specific solute carrier gated by voltage and cAMP. Nature, 623, 2023
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8PD7
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![BU of 8pd7 by Molmil](/molmil-images/mine/8pd7) | Ligand-free SpSLC9C1 in lipid nanodiscs, protomer state 4 | Descriptor: | Sperm-specific sodium proton exchanger | Authors: | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | Deposit date: | 2023-06-11 | Release date: | 2023-11-08 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of a sperm-specific solute carrier gated by voltage and cAMP. Nature, 623, 2023
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8PD5
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![BU of 8pd5 by Molmil](/molmil-images/mine/8pd5) | Ligand-free SpSLC9C1 in lipid nanodiscs, protomer state 3 | Descriptor: | Sperm-specific sodium proton exchanger | Authors: | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | Deposit date: | 2023-06-11 | Release date: | 2023-11-08 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of a sperm-specific solute carrier gated by voltage and cAMP. Nature, 623, 2023
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8PD2
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![BU of 8pd2 by Molmil](/molmil-images/mine/8pd2) | Ligand-free SpSLC9C1 in lipid nanodiscs, protomer state 1 | Descriptor: | Sperm-specific sodium proton exchanger | Authors: | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | Deposit date: | 2023-06-11 | Release date: | 2023-11-08 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Structures of a sperm-specific solute carrier gated by voltage and cAMP. Nature, 623, 2023
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8PD9
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![BU of 8pd9 by Molmil](/molmil-images/mine/8pd9) | cAMP-bound SpSLC9C1 in lipid nanodiscs, protomer state 1 | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Sperm-specific sodium proton exchanger | Authors: | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | Deposit date: | 2023-06-12 | Release date: | 2023-11-08 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of a sperm-specific solute carrier gated by voltage and cAMP. Nature, 623, 2023
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8PDV
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![BU of 8pdv by Molmil](/molmil-images/mine/8pdv) | cGMP-bound SpSLC9C1 in lipid nanodiscs, protomer | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, Sperm-specific sodium proton exchanger | Authors: | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | Deposit date: | 2023-06-12 | Release date: | 2023-11-08 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | Structures of a sperm-specific solute carrier gated by voltage and cAMP. Nature, 623, 2023
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8PDU
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![BU of 8pdu by Molmil](/molmil-images/mine/8pdu) | cGMP-bound SpSLC9C1 in lipid nanodiscs, dimer | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, Sperm-specific sodium proton exchanger | Authors: | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | Deposit date: | 2023-06-12 | Release date: | 2023-11-08 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | Structures of a sperm-specific solute carrier gated by voltage and cAMP. Nature, 623, 2023
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3TNP
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![BU of 3tnp by Molmil](/molmil-images/mine/3tnp) | Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme | Descriptor: | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type II-beta regulatory subunit | Authors: | Zhang, P, Smith-Nguyen, E.V, Keshwani, M.M, Deal, M.S, Kornev, A.P, Taylor, S.S. | Deposit date: | 2011-09-01 | Release date: | 2012-02-01 | Last modified: | 2013-02-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure and allostery of the PKA RIIbeta tetrameric holoenzyme Science, 335, 2012
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8T4M
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![BU of 8t4m by Molmil](/molmil-images/mine/8t4m) | Closed human HCN1 F186C S264C bound to cAMP, reconstituted in LMNG + SPL | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Authors: | Burtscher, V, Mount, J, Cowgill, J, Chang, Y, Bickel, K, Yuan, P, Chanda, B. | Deposit date: | 2023-06-09 | Release date: | 2024-06-12 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Structural basis for hyperpolarization-dependent opening of human HCN1 channel. Nat Commun, 15, 2024
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5DYL
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![BU of 5dyl by Molmil](/molmil-images/mine/5dyl) | Crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium Vivax - Apo form | Descriptor: | cGMP-dependent protein kinase, putative | Authors: | Wernimont, A.K, Tempel, W, He, H, Seitova, A, Hills, T, Neculai, A.M, Baker, D.A, Flueck, C, Kettleborough, C.A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Hutchinson, A, El Bakkouri, M, Structural Genomics Consortium (SGC) | Deposit date: | 2015-09-24 | Release date: | 2015-11-04 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation. Proc.Natl.Acad.Sci.USA, 116, 2019
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5E44
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![BU of 5e44 by Molmil](/molmil-images/mine/5e44) | Crystal structure of holo-FNR of A. fischeri | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, FNR regulator, IRON/SULFUR CLUSTER | Authors: | Volbeda, A, Fontecilla-Camps, J.C. | Deposit date: | 2015-10-05 | Release date: | 2015-12-16 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | The crystal structure of the global anaerobic transcriptional regulator FNR explains its extremely fine-tuned monomer-dimer equilibrium. Sci Adv, 1, 2015
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5DYK
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![BU of 5dyk by Molmil](/molmil-images/mine/5dyk) | Crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium falciparum - Apo form | Descriptor: | 1,2-ETHANEDIOL, CGMP-dependent protein kinase, GLYCEROL, ... | Authors: | Wernimont, A.K, Tempel, W, He, H, Seitova, A, Hills, T, Neculai, A.M, Baker, D.A, Flueck, C, Kettleborough, C.A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Hutchinson, A, El Bakkouri, M, Structural Genomics Consortium (SGC) | Deposit date: | 2015-09-24 | Release date: | 2015-11-04 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation. Proc.Natl.Acad.Sci.USA, 116, 2019
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5DZC
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![BU of 5dzc by Molmil](/molmil-images/mine/5dzc) | Crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium Vivax - AMPPNP bound | Descriptor: | CHLORIDE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SODIUM ION, ... | Authors: | Walker, J.R, El Bakkouri, M, Loppnau, P, Graslund, S, He, H, Seitova, A, Hutchinson, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Hui, R, Amani, M, Structural Genomics Consortium (SGC) | Deposit date: | 2015-09-25 | Release date: | 2015-10-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation. Proc.Natl.Acad.Sci.USA, 116, 2019
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8EP1
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![BU of 8ep1 by Molmil](/molmil-images/mine/8ep1) | |
8EM8
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![BU of 8em8 by Molmil](/molmil-images/mine/8em8) | Co-crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium falciparum in complex with RY-1-165 | Descriptor: | UNKNOWN ATOM OR ION, [(3R)-3-{[(4M)-4-(4-cyclopropyl-2-phenyl-1H-imidazol-1-yl)pyrimidin-2-yl]amino}pyrrolidin-1-yl](1,3-thiazol-2-yl)methanone, cGMP-dependent protein kinase, ... | Authors: | Hutchinson, A, Dong, A, Seitova, A, Bhanot, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | Deposit date: | 2022-09-27 | Release date: | 2022-11-02 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials. J.Med.Chem., 67, 2024
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8EOW
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![BU of 8eow by Molmil](/molmil-images/mine/8eow) | |
8EP0
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![BU of 8ep0 by Molmil](/molmil-images/mine/8ep0) | |