PDB: 974 resultsInfo pagesStatus searchChemie searchBIRD

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7RAR	Structure of Q67H mutant of disulfide stabilized HIV-1 CA hexamer Descriptor: CHLORIDE ION, Capsid protein p24, IODIDE ION Authors: Bester, S.M, Kvaratskhelia, M. Deposit date: 2021-07-02 Release date: 2022-09-28 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir. Mbio, 13, 2022
7RJ2	Co-crystal structure of lenacapavir bound to Q67H/N74D mutant of disulfide stabilized HIV-1 CA hexamer Descriptor: CHLORIDE ION, Capsid protein p24, IODIDE ION, ... Authors: Bester, S.M, Kvaratskhelia, M. Deposit date: 2021-07-20 Release date: 2022-07-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.32 Å) Cite: Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir. Mbio, 13, 2022
7RJ4	Co-crystal structure of lenacapavir bound to N74D mutant of disulfide stabilized HIV-1 CA hexamer Descriptor: CAPSID PROTEIN P24, CHLORIDE ION, IODIDE ION, ... Authors: Bester, S.M, Kvaratskhelia, M. Deposit date: 2021-07-20 Release date: 2022-07-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.32 Å) Cite: Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir. Mbio, 13, 2022
7RHN	Co-crystal structure of Q67H mutant of disulfide stabilized HIV-1 CA hexamer and lenacapavir Descriptor: CHLORIDE ION, Capsid protein p24, IODIDE ION, ... Authors: Bester, S.M, Kvaratskhelia, M. Deposit date: 2021-07-17 Release date: 2022-07-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.46 Å) Cite: Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir. Mbio, 13, 2022
7RHM	Structure of Q67H/N74D mutant of disulfide stabilized HIV-1 CA hexamer Descriptor: CAPSID PROTEIN P24, CHLORIDE ION, IODIDE ION Authors: Bester, S.M, Kvaratskhelia, M. Deposit date: 2021-07-17 Release date: 2022-07-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.16 Å) Cite: Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir. Mbio, 13, 2022
7RAO	Structure of M66I mutant of disulfide stabilized HIV-1 CA hexamer Descriptor: CHLORIDE ION, Capsid protein p24, IODIDE ION Authors: Bester, S.M, Kvaratskhelia, M. Deposit date: 2021-07-02 Release date: 2022-11-02 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.29 Å) Cite: Structural and mechanistic bases of viral resistance to long-acting HIV-1 capsid inhibitor, Lenacapavir To Be Published
7T13	Hexameric HIV-1 (M-group) CA Q50Y mutant Descriptor: Capsid protein p24 Authors: Jacques, D.A, James, L.C. Deposit date: 2021-12-01 Release date: 2022-10-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.15 Å) Cite: Evasion of cGAS and TRIM5 defines pandemic HIV. Nat Microbiol, 7, 2022
7T12	Hexameric HIV-1 (O-group) CA Descriptor: Capsid protein p24 Authors: Jacques, D.A, James, L.C. Deposit date: 2021-12-01 Release date: 2022-10-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3 Å) Cite: Evasion of cGAS and TRIM5 defines pandemic HIV. Nat Microbiol, 7, 2022
3H47	X-ray Structure of Hexameric HIV-1 CA Descriptor: Capsid protein p24 Authors: Pornillos, O. Deposit date: 2009-04-18 Release date: 2009-06-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: X-ray structures of the hexameric building block of the HIV capsid. Cell(Cambridge,Mass.), 137, 2009
3GV2	X-ray Structure of Hexameric HIV-1 CA Descriptor: Capsid protein p24,Carbon dioxide-concentrating mechanism protein CcmK homolog 4 Authors: Kelly, B.N. Deposit date: 2009-03-30 Release date: 2009-06-23 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (7 Å) Cite: X-ray structures of the hexameric building block of the HIV capsid. Cell(Cambridge,Mass.), 137, 2009
3H1Z	Molecular basis for the association of PIPKIgamma -p90 with the clathrin adaptor AP-2 Descriptor: AP-2 complex subunit beta-1, Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma Authors: Vahedi-Faridi, A, Kahlfeldt, N, Schaefer, J.G, Krainer, G, Keller, S, Saenger, W, Krauss, M, Haucke, V. Deposit date: 2009-04-14 Release date: 2009-11-24 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Molecular basis for association of PIPKI gamma-p90 with clathrin adaptor AP-2. J.Biol.Chem., 285, 2010
3H4E	X-ray Structure of Hexameric HIV-1 CA Descriptor: Capsid protein p24 Authors: Pornillos, O. Deposit date: 2009-04-19 Release date: 2009-06-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.704 Å) Cite: X-ray structures of the hexameric building block of the HIV capsid. Cell(Cambridge,Mass.), 137, 2009
3I60	Crystal structure of ERK2 bound to (S)-4-(2-(2-chlorophenylamino)-5-methylpyrimidin-4-yl)-N-(2-hydroxy-1-phenylethyl)-1H-pyrrole-2-carboxamide Descriptor: 4-{2-[(2-chlorophenyl)amino]-5-methylpyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-phenylethyl]-1H-pyrrole-2-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION Authors: Jacobs, M.D, Xie, X. Deposit date: 2009-07-06 Release date: 2010-01-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control. J.Med.Chem., 52, 2009
3HXI	Crystal structure of Schistosome eIF4E complexed with m7GpppG and 4E-BP Descriptor: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Eukaryotic Translation Initiation 4E, Eukaryotic translation initiation factor 4E-binding protein 1 Authors: Liu, W, Zhao, R, Jones, D.N.M, Davis, R.E. Deposit date: 2009-06-20 Release date: 2009-08-25 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural insights into parasite EIF4E binding specificity for m7G and m2,2,7G mRNA cap. J.Biol.Chem., 284, 2009
3HXG	Crystal structure of Schistsome eIF4E complexed with m7GpppA and 4E-BP Descriptor: Eukaryotic Translation Initiation Factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE Authors: Liu, W, Zhao, R, Jones, D.N.M, Davis, R.E. Deposit date: 2009-06-20 Release date: 2009-08-25 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural insights into parasite EIF4E binding specificity for m7G and m2,2,7G mRNA cap. J.Biol.Chem., 284, 2009
3I5Z	Crystal structure of ERK2 bound to (S)-N-(2-hydroxy-1-phenylethyl)-4-(5-methyl-2-(phenylamino)pyrimidin-4-yl)-1H-pyrrole-2-carboxamide Descriptor: Mitogen-activated protein kinase 1, N-[(1S)-2-hydroxy-1-phenylethyl]-4-[5-methyl-2-(phenylamino)pyrimidin-4-yl]-1H-pyrrole-2-carboxamide, SULFATE ION Authors: Jacobs, M.D, Xie, X. Deposit date: 2009-07-06 Release date: 2010-01-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control. J.Med.Chem., 52, 2009
3H85	Molecular basis for the association of PIPKI gamma-p90 with the clathrin adaptor AP-2 Descriptor: AP-2 complex subunit mu-1, NICKEL (II) ION, Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma Authors: Vahedi-Faridi, A, Kahlfeldt, N, Schaefer, J.G, Haucke, V. Deposit date: 2009-04-28 Release date: 2009-11-24 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Molecular basis for association of PIPKI gamma-p90 with clathrin adaptor AP-2. J.Biol.Chem., 285, 2010
7JUY	Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Cobimetinib Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ... Authors: Khan, Z.M, Dar, A.C. Deposit date: 2020-08-20 Release date: 2020-10-07 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.096 Å) Cite: Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUU	Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor PD0325901 Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, MAGNESIUM ION, ... Authors: Khan, Z.M, Dar, A.C. Deposit date: 2020-08-20 Release date: 2020-09-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.19 Å) Cite: Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUZ	Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Selumetinib Descriptor: 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, ... Authors: Khan, Z.M, Dar, A.C. Deposit date: 2020-08-20 Release date: 2020-09-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.21 Å) Cite: Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUV	Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor APS-9-95-1 Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, MAGNESIUM ION, ... Authors: Khan, Z.M, Dar, A.C, Scopton, A.P. Deposit date: 2020-08-20 Release date: 2020-09-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.36 Å) Cite: Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUT	Crystal Structure of KSR2:MEK1 in complex with ANP-PNP, and allosteric MEK inhibitor Selumetinib Descriptor: 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, ... Authors: Khan, Z.M, Dar, A.C. Deposit date: 2020-08-20 Release date: 2020-09-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.09 Å) Cite: Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUS	Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Cobimetinib Descriptor: Cobimetinib, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, ... Authors: Khan, Z.M, Dar, A.C. Deposit date: 2020-08-20 Release date: 2020-09-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.99 Å) Cite: Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JV0	Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor PD0325901 Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ... Authors: Khan, Z.M, Dar, A.C. Deposit date: 2020-08-20 Release date: 2020-09-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.63 Å) Cite: Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUW	Crystal Structure of KSR1:MEK1 in complex with AMP-PNP Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ... Authors: Khan, Z.M, Dar, A.C. Deposit date: 2020-08-20 Release date: 2020-09-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.88 Å) Cite: Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020

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