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5MNG	Cationic trypsin in complex with benzamidine (deuterated sample at 100 K) Descriptor: BENZAMIDINE, CALCIUM ION, Cationic trypsin, ... Authors: Schiebel, J, Heine, A, Klebe, G. Deposit date: 2016-12-13 Release date: 2018-01-17 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (0.86 Å) Cite: Intriguing role of water in protein-ligand binding studied by neutron crystallography on trypsin complexes. Nat Commun, 9, 2018
5MNZ	Neutron structure of cationic trypsin in its apo form Descriptor: CALCIUM ION, Cationic trypsin Authors: Schiebel, J, Schrader, T.E, Ostermann, A, Heine, A, Klebe, G. Deposit date: 2016-12-13 Release date: 2018-01-17 Last modified: 2024-01-17 Method: NEUTRON DIFFRACTION (1.45 Å) Cite: Intriguing role of water in protein-ligand binding studied by neutron crystallography on trypsin complexes. Nat Commun, 9, 2018
5MOS	Joint X-ray/neutron structure of cationic trypsin in complex with N-amidinopiperidine Descriptor: CALCIUM ION, Cationic trypsin, SULFATE ION, ... Authors: Schiebel, J, Schrader, T.E, Ostermann, A, Heine, A, Klebe, G. Deposit date: 2016-12-14 Release date: 2018-02-28 Last modified: 2024-05-01 Method: NEUTRON DIFFRACTION (0.96 Å), X-RAY DIFFRACTION Cite: Intriguing role of water in protein-ligand binding studied by neutron crystallography on trypsin complexes. Nat Commun, 9, 2018
6D40	Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma Descriptor: Plasminogen, SULFATE ION, Trypsin inhibitor 1 Authors: Law, R.H.P, Wu, G. Deposit date: 2018-04-17 Release date: 2019-01-23 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.43 Å) Cite: Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma. J. Med. Chem., 62, 2019
6D3Y	Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma Descriptor: GLYCEROL, Plasminogen, SULFATE ION, ... Authors: Law, R.H.P, Wu, G. Deposit date: 2018-04-17 Release date: 2019-01-23 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.32 Å) Cite: Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma. J. Med. Chem., 62, 2019
5MNH	Cationic trypsin in complex with benzamidine (deuterated sample at 295 K) Descriptor: BENZAMIDINE, CALCIUM ION, Cationic trypsin, ... Authors: Schiebel, J, Heine, A, Klebe, G. Deposit date: 2016-12-13 Release date: 2018-01-17 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (0.93 Å) Cite: Intriguing role of water in protein-ligand binding studied by neutron crystallography on trypsin complexes. Nat Commun, 9, 2018
5MNO	Cationic trypsin in complex with N-amidinopiperidine (deuterated sample at 295 K) Descriptor: CALCIUM ION, Cationic trypsin, SULFATE ION, ... Authors: Schiebel, J, Heine, A, Klebe, G. Deposit date: 2016-12-13 Release date: 2018-01-17 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (0.96 Å) Cite: Intriguing role of water in protein-ligand binding studied by neutron crystallography on trypsin complexes. Nat Commun, 9, 2018
5MOQ	Joint X-ray/neutron structure of cationic trypsin in complex with benzamidine Descriptor: BENZAMIDINE, CALCIUM ION, Cationic trypsin, ... Authors: Schiebel, J, Schrader, T.E, Ostermann, A, Heine, A, Klebe, G. Deposit date: 2016-12-14 Release date: 2018-02-28 Last modified: 2024-05-01 Method: NEUTRON DIFFRACTION (0.93 Å), X-RAY DIFFRACTION Cite: Intriguing role of water in protein-ligand binding studied by neutron crystallography on trypsin complexes. Nat Commun, 9, 2018
6D3X	Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma Descriptor: Plasminogen, Trypsin inhibitor 1 Authors: Law, R.H.P, Wu, G. Deposit date: 2018-04-17 Release date: 2019-01-23 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma. J. Med. Chem., 62, 2019
2FMJ	220-loop mutant of streptomyces griseus trypsin Descriptor: CALCIUM ION, SULFATE ION, Trypsin Authors: Page, M.J, Di Cera, E. Deposit date: 2006-01-09 Release date: 2006-05-23 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Conversion of trypsin into a Na(+)-activated enzyme. Biochemistry, 45, 2006
1ANC	ANIONIC TRYPSIN MUTANT WITH SER 214 REPLACED BY LYS Descriptor: ANIONIC TRYPSIN, BENZAMIDINE, CALCIUM ION Authors: Fletterick, R.J, Mcgrath, M.E. Deposit date: 1994-12-21 Release date: 1997-04-01 Last modified: 2021-11-03 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Perturbing the polar environment of Asp102 in trypsin: consequences of replacing conserved Ser214. Biochemistry, 31, 1992
1ANB	ANIONIC TRYPSIN MUTANT WITH SER 214 REPLACED BY GLU Descriptor: ANIONIC TRYPSIN, BENZAMIDINE, CALCIUM ION Authors: Fletterick, R.J, Mcgrath, M.E. Deposit date: 1994-12-21 Release date: 1997-04-01 Last modified: 2021-11-03 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Perturbing the polar environment of Asp102 in trypsin: consequences of replacing conserved Ser214. Biochemistry, 31, 1992
3RDZ	Crystal Structure of rBTI-trypsin complex at 2.26 angstrom resolution Descriptor: BWI-1=PROTEASE inhibitor/trypsin inhibitor, CALCIUM ION, Cationic trypsin Authors: Wang, L.F, Li, M, Chang, W.R. Deposit date: 2011-04-02 Release date: 2011-07-06 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.262 Å) Cite: Conformational Changes of rBTI from Buckwheat upon Binding to Trypsin: Implications for the Role of the P(8)' Residue in the Potato Inhibitor I Family Plos One, 6, 2011
2TIO	LOW PACKING DENSITY FORM OF BOVINE BETA-TRYPSIN IN CYCLOHEXANE Descriptor: BENZAMIDINE, CALCIUM ION, HEXANE, ... Authors: Huang, Q, Zhu, G, Tang, Q. Deposit date: 1998-09-23 Release date: 1998-09-30 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.93 Å) Cite: X-ray studies on two forms of bovine beta-trypsin crystals in neat cyclohexane. Biochim.Biophys.Acta, 1429, 1998
3VPK	Crystal Structure of 6-Guanidinohexanoyl Trypsin Descriptor: 6-carbamimidamidohexanoic acid, CALCIUM ION, Cationic trypsin, ... Authors: Masuda, Y, Nitanai, Y, Mizutani, R, Noguchi, S. Deposit date: 2012-03-05 Release date: 2012-05-23 Last modified: 2013-02-06 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Crystal structure of 6-guanidinohexanoyl trypsin near the optimum pH reveals the acyl-enzyme intermediate to be deacylated Proteins, 2012
2TLD	CRYSTAL STRUCTURE OF AN ENGINEERED SUBTILISIN INHIBITOR COMPLEXED WITH BOVINE TRYPSIN Descriptor: STREPTOMYCES SUBTILISIN INHIBITOR (SSI), TRYPSIN Authors: Mitsui, Y, Takeuchi, Y, Nonaka, T, Nakamura, K.T. Deposit date: 1991-09-16 Release date: 1992-07-15 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structure of an engineered subtilisin inhibitor complexed with bovine trypsin. Proc.Natl.Acad.Sci.USA, 89, 1992
1V6D	The crystal structure of the trypsin complex with synthetic heterochiral peptide Descriptor: ACETATE ION, CALCIUM ION, METHYLAMINE, ... Authors: Shamaladevi, N, Pattabhi, V. Deposit date: 2003-11-28 Release date: 2004-12-07 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Secondary binding site of trypsin: revealed by crystal structure of trypsin-peptide complex. J.Biomol.Struct.Dyn., 22, 2005
3P95	Human mesotrypsin complexed with bovine pancreatic trypsin inhibitor variant (BPTI-K15R/R17D) Descriptor: CALCIUM ION, PRSS3 protein, Pancreatic trypsin inhibitor Authors: Salameh, M.A, Soares, A.S, Radisky, E.S. Deposit date: 2010-10-15 Release date: 2011-08-31 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.2991 Å) Cite: The P2' residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity. Biochem.J., 440, 2011
2VU8	Crystal structure of an insect inhibitor with a fungal trypsin Descriptor: PACIFASTIN-RELATED SERINE PROTEASE INHIBITOR, TRYPSIN Authors: Leone, P, Roussel, A, Kellenberger, C. Deposit date: 2008-05-21 Release date: 2008-12-23 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure of Locusta Migratoria Protease Inhibitor 3 (Lmpi-3) in Complex with Fusarium Oxysporum Trypsin. Acta Crystallogr.,Sect.D, 64, 2008
2TRM	THE THREE-DIMENSIONAL STRUCTURE OF ASN102 MUTANT OF TRYPSIN. ROLE OF ASP102 IN SERINE PROTEASE CATALYSIS Descriptor: BENZAMIDINE, CALCIUM ION, TRYPSIN Authors: Stroud, R.M, Finer-Moore, J. Deposit date: 1988-04-25 Release date: 1988-07-16 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2.8 Å) Cite: The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis. Science, 237, 1987
3P92	Human mesotrypsin complexed with bovine pancreatic trypsin inhibitor variant (BPTI-K15R/R17G) Descriptor: CALCIUM ION, PRSS3 protein, Pancreatic trypsin inhibitor Authors: Salameh, M.A, Soares, A.S, Radisky, E.S. Deposit date: 2010-10-15 Release date: 2011-08-31 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.5992 Å) Cite: The P2' residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity. Biochem.J., 440, 2011
4DOQ	Crystal structure of the complex of Porcine Pancreatic Trypsin with 1/2SLPI Descriptor: 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL, Antileukoproteinase, CALCIUM ION, ... Authors: Fukushima, K, Takimoto-Kamimura, M. Deposit date: 2012-02-10 Release date: 2013-08-14 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure basis 1/2SLPI and porcine pancreas trypsin interaction J.SYNCHROTRON RADIAT., 20, 2013
2ILN	Crystal structure of the Bowman-Birk inhibitor from snail medic seeds in complex with bovine trypsin Descriptor: Bowman-Birk type proteinase inhibitor, Cationic trypsin Authors: Capaldi, S, Perduca, M, Faggion, B, Carrizo, M.E, Tava, A, Ragona, L, Monaco, H.L. Deposit date: 2006-10-03 Release date: 2007-04-10 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of the anticarcinogenic Bowman-Birk inhibitor from snail medic (Medicago scutellata) seeds complexed with bovine trypsin J.Struct.Biol., 158, 2007
6SVD	Non-terahertz irradiated structure of bovine trypsin (even frames of crystal x41) Descriptor: BENZAMIDINE, CALCIUM ION, Cationic trypsin, ... Authors: Ahlberg Gagner, V, Lundholm, I, Garcia-Bonete, M.J, Rodilla, H, Friedman, R, Zhaunerchyk, V, Bourenkov, G, Schneider, T, Stake, J, Katona, G. Deposit date: 2019-09-18 Release date: 2020-01-22 Last modified: 2020-01-29 Method: X-RAY DIFFRACTION (1.15 Å) Cite: Clustering of atomic displacement parameters in bovine trypsin reveals a distributed lattice of atoms with shared chemical properties. Sci Rep, 9, 2019
6SVW	Reference structure of bovine trypsin (even frames of crystal x33) Descriptor: BENZAMIDINE, CALCIUM ION, Cationic trypsin, ... Authors: Ahlberg Gagner, V, Lundholm, I, Garcia-Bonete, M.J, Rodilla, H, Friedman, R, Zhaunerchyk, V, Bourenkov, G, Schneider, T, Stake, J, Katona, G. Deposit date: 2019-09-19 Release date: 2020-01-22 Last modified: 2020-01-29 Method: X-RAY DIFFRACTION (1.16 Å) Cite: Clustering of atomic displacement parameters in bovine trypsin reveals a distributed lattice of atoms with shared chemical properties. Sci Rep, 9, 2019

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