3VPK
Crystal Structure of 6-Guanidinohexanoyl Trypsin
Summary for 3VPK
Entry DOI | 10.2210/pdb3vpk/pdb |
Descriptor | Cationic trypsin, 6-carbamimidamidohexanoic acid, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | acyl-enzyme intermediate, serine protease inhibitor, trypsin, serine protease, digestion, anti-pancreatitis drug, leaving group, catalytic water molecule, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Bos taurus (bovine) |
Cellular location | Secreted, extracellular space: P00760 |
Total number of polymer chains | 1 |
Total formula weight | 23703.75 |
Authors | Masuda, Y.,Nitanai, Y.,Mizutani, R.,Noguchi, S. (deposition date: 2012-03-05, release date: 2012-05-23, Last modification date: 2013-02-06) |
Primary citation | Masuda, Y.,Nitanai, Y.,Mizutani, R.,Noguchi, S. Crystal structure of 6-guanidinohexanoyl trypsin near the optimum pH reveals the acyl-enzyme intermediate to be deacylated Proteins, 2012 Cited by PubMed: 23161653DOI: 10.1002/prot.24206 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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