4O45
| WDR5 in complex with influenza NS1 C-terminal tail | Descriptor: | Nonstructural protein 1, UNKNOWN ATOM OR ION, WD repeat-containing protein 5 | Authors: | Qin, S, Xu, C, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2013-12-18 | Release date: | 2014-04-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1. Nat Commun, 5, 2014
|
|
3BQO
| Crystal Structure of TRF1 TRFH domain and TIN2 peptide complex | Descriptor: | TERF1-interacting nuclear factor 2, Telomeric repeat-binding factor 1 | Authors: | Chen, Y, Yang, Y, van Overbeek, M, Donigian, J.R, Baciu, P, de Lange, T, Lei, M. | Deposit date: | 2007-12-20 | Release date: | 2008-02-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science, 319, 2008
|
|
2V3T
| Structure of the ligand-binding core of the ionotropic glutamate receptor-like GluRdelta2 in the apo form | Descriptor: | CALCIUM ION, GLUTAMATE RECEPTOR DELTA-2 SUBUNIT SYNONYM GLURDELTA2, GLUR DELTA-2 | Authors: | Naur, P, Vestergaard, B, Gajhede, M, Kastrup, J.S. | Deposit date: | 2007-06-22 | Release date: | 2007-08-07 | Last modified: | 2019-07-24 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Ionotropic Glutamate-Like Receptor {Delta}2 Binds D-Serine and Glycine. Proc.Natl.Acad.Sci.USA, 104, 2007
|
|
2VF9
| |
6FTG
| |
7VCU
| Human p97 double hexamer conformer I with D1-ATPgammaS and D2-ADP bound | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. | Deposit date: | 2021-09-04 | Release date: | 2022-03-02 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state. Cell Discov, 8, 2022
|
|
4MD8
| |
7VCT
| Human p97 single hexamer conformer III with D1-ATPgammaS and D2-ADP bound | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. | Deposit date: | 2021-09-04 | Release date: | 2022-03-02 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state. Cell Discov, 8, 2022
|
|
7VCX
| Human p97 single hexamer conformer II with ATPgammaS bound | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | Authors: | Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. | Deposit date: | 2021-09-04 | Release date: | 2022-03-02 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state. Cell Discov, 8, 2022
|
|
7VCV
| Human p97 single hexamer conformer I with ATPgammaS bound | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | Authors: | Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. | Deposit date: | 2021-09-04 | Release date: | 2022-03-02 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state. Cell Discov, 8, 2022
|
|
7VCS
| Human p97 double hexamer conformer II with ATPgammaS bound | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | Authors: | Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. | Deposit date: | 2021-09-03 | Release date: | 2022-03-02 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state. Cell Discov, 8, 2022
|
|
5V8I
| Thermus thermophilus 70S ribosome lacking ribosomal protein uS17 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | Authors: | Gregory, S.T, Jogl, G. | Deposit date: | 2017-03-22 | Release date: | 2018-03-28 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Structural robustness of the ribosome inferred from X-ray crystal structures of the 30S ribosomal subunit and the 70S ribosome lacking ribosomal protein uS17 To be published
|
|
2XP2
| Structure of the Human Anaplastic Lymphoma Kinase in Complex with Crizotinib (PF-02341066) | Descriptor: | 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, TYROSINE-PROTEIN KINASE RECEPTOR | Authors: | McTigue, M, Deng, Y, Liu, W, Brooun, A, Timofeevski, S, Marrone, T, Cui, J.J. | Deposit date: | 2010-08-24 | Release date: | 2010-09-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure Based Drug Design of Crizotinib (Pf-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal-Epithelial Transition Factor (C-met) Kinase and Anaplastic Lymphoma Kinase (Alk). J.Med.Chem, 54, 2011
|
|
8OOV
| human NME-1 in complex with CoA | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3'-PHOSPHATE-ADENOSINE-5'-DIPHOSPHATE, Nucleoside diphosphate kinase A | Authors: | Gouge, J, Hristov, H.D. | Deposit date: | 2023-04-06 | Release date: | 2023-06-07 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A Unique Mode of Coenzyme A Binding to the Nucleotide Binding Pocket of Human Metastasis Suppressor NME1. Int J Mol Sci, 24, 2023
|
|
6TBL
| |
6TBN
| Crystal structure of CIAO1-CIAO2B CIA core complex | Descriptor: | MIP18 family protein galla-2, Probable cytosolic iron-sulfur protein assembly protein Ciao1, SODIUM ION | Authors: | Kassube, S.A, Thoma, N.H. | Deposit date: | 2019-11-01 | Release date: | 2020-07-29 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural insights into Fe-S protein biogenesis by the CIA targeting complex. Nat.Struct.Mol.Biol., 27, 2020
|
|
5UG8
| Crystal structure of the EGFR kinase domain (L858R, T790M, V948R) in complex with a covalent inhibitor N-[(3R,4R)-4-fluoro-1-{6-[(1-methyl-1H-pyrazol-4-yl)amino]-9-(propan-2-yl)-9H-purin-2-yl}pyrrolidin-3-yl]propanamide | Descriptor: | Epidermal growth factor receptor, GLYCEROL, N-[(3R,4R)-4-fluoro-1-{6-[(1-methyl-1H-pyrazol-4-yl)amino]-9-(propan-2-yl)-9H-purin-2-yl}pyrrolidin-3-yl]propanamide, ... | Authors: | Gajiwala, K.S, Ferre, R.A. | Deposit date: | 2017-01-07 | Release date: | 2017-03-22 | Last modified: | 2017-04-26 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR. J. Med. Chem., 60, 2017
|
|
5VUB
| Pim1 Kinase in complex with a benzofuranone inhibitor | Descriptor: | (2Z)-6-methoxy-7-(piperazin-1-ylmethyl)-2-(1H-pyrrolo[3,2-b]pyridin-3-ylmethylidene)-1-benzofuran-3-one, GLYCEROL, Serine/threonine-protein kinase pim-1 | Authors: | Parker, L.J. | Deposit date: | 2017-05-18 | Release date: | 2017-12-13 | Last modified: | 2018-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Theoretical Analysis of Activity Cliffs among Benzofuranone-Class Pim1 Inhibitors Using the Fragment Molecular Orbital Method with Molecular Mechanics Poisson-Boltzmann Surface Area (FMO+MM-PBSA) Approach J Chem Inf Model, 57, 2017
|
|
7KPF
| NME2 bound to myristoyl-CoA | Descriptor: | GLYCEROL, MAGNESIUM ION, Nucleoside diphosphate kinase B, ... | Authors: | Price, I.R, Lin, H. | Deposit date: | 2020-11-11 | Release date: | 2022-02-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | A Chemical Proteomic Approach reveals the regulation of NME1/2 and cancer metastasis by Long-Chain Fatty Acyl Coenzyme A To Be Published
|
|
5VJI
| Crystal structure of the CLOCK Transcription Domain Exon19 in Complex with a Repressor | Descriptor: | CLOCK-interacting pacemaker, Circadian locomoter output cycles protein kaput | Authors: | Hou, Z, Su, L, Pei, J, Grishin, N.V, Zhang, H. | Deposit date: | 2017-04-19 | Release date: | 2017-06-07 | Last modified: | 2020-01-01 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Crystal Structure of the CLOCK Transactivation Domain Exon19 in Complex with a Repressor. Structure, 25, 2017
|
|
2WPH
| factor IXa superactive triple mutant | Descriptor: | CALCIUM ION, COAGULATION FACTOR IXA HEAVY CHAIN, COAGULATION FACTOR IXA LIGHT CHAIN, ... | Authors: | Zogg, T, Brandstetter, H. | Deposit date: | 2009-08-06 | Release date: | 2009-12-22 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa Structure, 17, 2009
|
|
6FTJ
| Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the Non-programmed 80S Ribosome | Descriptor: | 28S rRNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Braunger, K, Becker, T, Beckmann, R. | Deposit date: | 2018-02-22 | Release date: | 2018-03-21 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum. Science, 360, 2018
|
|
2WV5
| Crystal structure of foot-and-mouth disease virus 3C protease in complex with a decameric peptide corresponding to the VP1-2A cleavage junction with a GLN to Glu substitution at P1 | Descriptor: | FOOT AND MOUTH DISEASE VIRUS (SEROTYPE A) VARIANT VP1 CAPSID PROTEIN, PICORNAIN 3C | Authors: | Zunszain, P.A, Knox, S.R, Sweeney, T.R, Yang, J, Roque-Rosell, N, Belsham, G.J, Leatherbarrow, R.J, Curry, S. | Deposit date: | 2009-10-13 | Release date: | 2009-10-27 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Insights Into Cleavage Specificity from the Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease Complexed with a Peptide Substrate. J.Mol.Biol., 395, 2010
|
|
5VPP
| The 70S P-site tRNA SufA6 complex | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Hong, S, Sunita, S, Dunkle, J.A, Maehigashi, T, Dunham, C.M. | Deposit date: | 2017-05-05 | Release date: | 2018-09-26 | Last modified: | 2018-11-07 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | Mechanism of tRNA-mediated +1 ribosomal frameshifting. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
2YFX
| Structure of L1196M Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib | Descriptor: | 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, TYROSINE-PROTEIN KINASE RECEPTOR | Authors: | McTigue, M, Deng, Y, Liu, W, Brooun, A. | Deposit date: | 2011-04-08 | Release date: | 2011-05-04 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib. J.Med.Chem., 57, 2014
|
|