3EVM
| Crystal structure of the Mimivirus NDK +Kpn-N62L-R107G triple mutant complexed with dCDP | Descriptor: | DEOXYCYTIDINE DIPHOSPHATE, MAGNESIUM ION, Nucleoside diphosphate kinase | Authors: | Jeudy, S, Lartigue, A, Claverie, J.M, Abergel, C. | Deposit date: | 2008-10-13 | Release date: | 2009-08-11 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Dissecting the unique nucleotide specificity of mimivirus nucleoside diphosphate kinase. J.Virol., 83, 2009
|
|
1IAN
| HUMAN P38 MAP KINASE INHIBITOR COMPLEX | Descriptor: | 4-[5-(3-IODO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-1H-IMIDAZOL-4-YL]-PYRIDINE, P38 MAP KINASE | Authors: | Tong, L. | Deposit date: | 1997-03-07 | Release date: | 1998-05-06 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket. Nat.Struct.Biol., 4, 1997
|
|
6U62
| Raptor-Rag-Ragulator complex | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Rogala, K.B, Sabatini, D.M. | Deposit date: | 2019-08-29 | Release date: | 2019-10-30 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | Structural basis for the docking of mTORC1 on the lysosomal surface. Science, 366, 2019
|
|
3F0A
| Structure of a putative n-acetyltransferase (ta0374) in complex with acetyl-coa from thermoplasma acidophilum | Descriptor: | ACETYL COENZYME *A, CHLORIDE ION, N-ACETYLTRANSFERASE, ... | Authors: | Filippova, E.V, Minasov, G, Shuvalova, L, Kiryukhina, O, Clancy, S, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2008-10-24 | Release date: | 2008-11-11 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of the novel PaiA N-acetyltransferase from Thermoplasma acidophilum involved in the negative control of sporulation and degradative enzyme production. Proteins, 79, 2011
|
|
3F1Q
| Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 1 | Descriptor: | (2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide, ACETIC ACID, Dihydroorotate dehydrogenase, ... | Authors: | Heikkila, T, Davies, M, McConkey, G.A, Fishwick, C.W.G, Parsons, M.R, Johnson, A.P. | Deposit date: | 2008-10-28 | Release date: | 2009-06-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J.Med.Chem., 52, 2009
|
|
3X1H
| hPPARgamma Ligand binding domain in complex with 5-oxo-tricosahexaenoic acid | Descriptor: | (7E,11Z,14Z,17Z,20Z)-5-oxotricosa-7,11,14,17,20-pentaenoic acid, Peroxisome proliferator-activated receptor gamma | Authors: | Egawa, D, Itoh, T, Yamamoto, K. | Deposit date: | 2014-11-18 | Release date: | 2015-04-08 | Last modified: | 2022-08-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Characterization of covalent bond formation between PPAR gamma and oxo-fatty acids. Bioconjug.Chem., 26, 2015
|
|
2WHH
| HIV-1 protease tethered dimer Q-product complex along with nucleophilic water molecule | Descriptor: | GLUTAMIC ACID, PARA-NITROPHENYLALANINE, POL PROTEIN | Authors: | Prashar, V, Bihani, S, Das, A, Ferrer, J.L, Hosur, M.V. | Deposit date: | 2009-05-05 | Release date: | 2009-12-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Catalytic Water Co-Existing with a Product Peptide in the Active Site of HIV-1 Protease Revealed by X- Ray Structure Analysis. Plos One, 4, 2009
|
|
3EXV
| |
3X1I
| hPPARgamma Ligand binding domain in complex with 6-oxo-tetracosahexaenoic acid | Descriptor: | (8E,12Z,15Z,18Z,21Z)-6-oxotetracosa-8,12,15,18,21-pentaenoic acid, Peroxisome proliferator-activated receptor gamma | Authors: | Egawa, D, Itoh, T, Yamamoto, K. | Deposit date: | 2014-11-18 | Release date: | 2015-04-08 | Last modified: | 2022-08-24 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Characterization of covalent bond formation between PPAR gamma and oxo-fatty acids. Bioconjug.Chem., 26, 2015
|
|
3FCG
| Crystal Structure Analysis of the Middle Domain of the Caf1A Usher | Descriptor: | CHLORIDE ION, F1 capsule-anchoring protein | Authors: | Yu, X, Visweswaran, G.R, Duck, Z, Marupakula, S, MacIntyre, S, Knight, S, Zavialov, A.V. | Deposit date: | 2008-11-21 | Release date: | 2008-12-16 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Caf1A usher possesses a Caf1 subunit-like domain that is crucial for Caf1 fibre secretion Biochem.J., 418, 2009
|
|
5C9Z
| |
6AC8
| Crystal structure of Mycobacterium smegmatis Mfd at 2.75 A resolution | Descriptor: | Mycobacterium smegmatis Mfd, SULFATE ION | Authors: | Putta, S, Fox, G.C, Walsh, M.A, Rao, D.N, Nagaraja, V, Natesh, R. | Deposit date: | 2018-07-25 | Release date: | 2019-08-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural basis for nucleotide-mediated remodelling mechanism of Mycobacterium Mfd To Be Published
|
|
6XF9
| Crystal structure of KSHV ORF68 | Descriptor: | Packaging protein UL32, ZINC ION | Authors: | Didychuk, A.L, Gates, S.N, Martin, A, Glaunsinger, B. | Deposit date: | 2020-06-15 | Release date: | 2021-02-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | A pentameric protein ring with novel architecture is required for herpesviral packaging. Elife, 10, 2021
|
|
6XFA
| Cryo-EM structure of EBV BFLF1 | Descriptor: | Packaging protein UL32, ZINC ION | Authors: | Didychuk, A.L, Gates, S.N, Martin, A, Glaunsinger, B. | Deposit date: | 2020-06-15 | Release date: | 2021-02-24 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | A pentameric protein ring with novel architecture is required for herpesviral packaging. Elife, 10, 2021
|
|
7R7S
| p47-bound p97-R155H mutant with ATPgammaS | Descriptor: | NSFL1 cofactor p47, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | Authors: | Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Malyutin, A.G, Poh, Y.-P, Chou, T.-F, Chiu, P.-L. | Deposit date: | 2021-06-25 | Release date: | 2021-08-04 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.23 Å) | Cite: | Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes. Int J Mol Sci, 22, 2021
|
|
7R7T
| p47-bound p97-R155H mutant with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, NSFL1 cofactor p47, Transitional endoplasmic reticulum ATPase | Authors: | Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Malyutin, A.G, Poh, Y.-P, Chou, T.-F, Chiu, P.-L. | Deposit date: | 2021-06-25 | Release date: | 2021-08-04 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes. Int J Mol Sci, 22, 2021
|
|
7R7U
| D1 and D2 domain structure of the p97(R155H)-p47 complex | Descriptor: | Transitional endoplasmic reticulum ATPase | Authors: | Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Poh, Y.-P, Chou, T.-F, Chiu, P.-L. | Deposit date: | 2021-06-25 | Release date: | 2021-08-04 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes. Int J Mol Sci, 22, 2021
|
|
7RLH
| Cryo-EM structure of human p97-D592N mutant bound to ATPgS. | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | Authors: | Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S. | Deposit date: | 2021-07-23 | Release date: | 2021-09-22 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation. J.Biol.Chem., 297, 2021
|
|
7RLG
| Cryo-EM structure of human p97-D592N mutant bound to ADP. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | Authors: | Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S. | Deposit date: | 2021-07-23 | Release date: | 2021-09-22 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation. J.Biol.Chem., 297, 2021
|
|
5U6I
| Discovery of MLi-2, an Orally Available and Selective LRRK2 Inhibitor that Reduces Brain Kinase Activity | Descriptor: | 3-[2-(morpholin-4-yl)pyridin-4-yl]-5-[(propan-2-yl)oxy]-1H-indazole, Mitogen-activated protein kinase 1, SULFATE ION | Authors: | Scott, J.D, DeMong, D.E, Fell, M.J, Mirescu, C, Basu, K, Greshock, T.J, Morrow, J.A, Xiao, L, Hruza, A, Harris, J, Tiscia, H.E, Chang, R.K, Embrey, M.W, McCauley, J.A, Li, W, Lin, S, Liu, H, Dai, X, Baptista, M, Agnihotri, G, Columbus, J, Mei, H, Poirier, M, Zhou, X, Lin, Y, Yin, Z, Sanders, J.M, Drolet, R.E, Kern, J.T, Kennedy, M.E, Parker, E.M, Stamford, A.W, Nargund, R, Miller, M.W. | Deposit date: | 2016-12-08 | Release date: | 2017-03-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity. J. Med. Chem., 60, 2017
|
|
7XAY
| Crystal structure of Hat1-Hat2-Asf1-H3-H4 | Descriptor: | COENZYME A, Histone H3, Histone H4, ... | Authors: | Yue, Y, Yang, W.S, Xu, R.M. | Deposit date: | 2022-03-19 | Release date: | 2022-05-18 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Topography of histone H3-H4 interaction with the Hat1-Hat2 acetyltransferase complex. Genes Dev., 36, 2022
|
|
6X4A
| Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with 5-chloro-7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-8-methyl-2-naphthonitrile (JLJ651), a Non-nucleoside Inhibitor | Descriptor: | 5-chloro-7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-8-methyl-2-naphthonitrile, Reverse transcriptase/ribonuclease H, SULFATE ION, ... | Authors: | Chan, A.H, Duong, V.N, Ippolito, J.A, Jorgensen, W.L, Anderson, K.S. | Deposit date: | 2020-05-22 | Release date: | 2020-07-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.537 Å) | Cite: | Structural investigation of 2-naphthyl phenyl ether inhibitors bound to WT and Y181C reverse transcriptase highlights key features of the NNRTI binding site. Protein Sci., 29, 2020
|
|
4G56
| Crystal Structure of full length PRMT5/MEP50 complexes from Xenopus laevis | Descriptor: | Hsl7 protein, MGC81050 protein, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Ho, M, Wilczek, C, Bonanno, J, Shechter, D, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2012-07-17 | Release date: | 2012-10-03 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structure of the arginine methyltransferase PRMT5-MEP50 reveals a mechanism for substrate specificity Plos One, 8, 2013
|
|
7RLC
| Cryo-EM structure of human p97-A232E mutant bound to ATPgS. | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | Authors: | Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S. | Deposit date: | 2021-07-23 | Release date: | 2021-09-22 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation. J.Biol.Chem., 297, 2021
|
|
7RLA
| Cryo-EM structure of human p97-R191Q mutant bound to ATPgS. | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | Authors: | Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S. | Deposit date: | 2021-07-23 | Release date: | 2021-09-22 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation. J.Biol.Chem., 297, 2021
|
|