3X1H

hPPARgamma Ligand binding domain in complex with 5-oxo-tricosahexaenoic acid

Summary for 3X1H

Related3X1I
DescriptorPeroxisome proliferator-activated receptor gamma, (7E,11Z,14Z,17Z,20Z)-5-oxotricosa-7,11,14,17,20-pentaenoic acid (3 entities in total)
Functional Keywordsnuclear receptor, transcription regulation, ligand binding domain, diabetes mellitus, zinc-finger, dna-binding, transcription, obesity
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight63616.07
Authors
Egawa, D.,Itoh, T.,Yamamoto, K. (deposition date: 2014-11-18, release date: 2015-04-08, Last modification date: 2017-11-22)
Primary citation
Egawa, D.,Itoh, T.,Yamamoto, K.
Characterization of Covalent Bond Formation between PPAR gamma and Oxo-Fatty Acids
Bioconjug.Chem., 2015
PubMed: 25785518 (PDB entries with the same primary citation)
DOI: 10.1021/acs.bioconjchem.5b00021
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.260150.4%2.7%11.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report