PDB: 1366 件ウェブページステータス検索Chemie searchBIRD

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7LS4	Co-complex CYP46A1 with 9129 (1b) 分子名称: Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, [5,5-dimethyl-3-(2-methylphenyl)-4~{H}-pyrazol-1-yl]-pyridin-4-yl-methanone 著者 Lane, W, Yano, J. 登録日 2021-02-17 公開日 2021-08-25 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H). J.Med.Chem., 64, 2021
7LRL	Co-complex CYP46A1 with 7742 (Soticlestat/TAK-935)) 分子名称: Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, [4-oxidanyl-4-(phenylmethyl)piperidin-1-yl]-(2-pyridin-4-ylpyridin-3-yl)methanone 著者 Lane, W, Yano, J. 登録日 2021-02-16 公開日 2021-08-25 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.995 Å) 主引用文献 Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H). J.Med.Chem., 64, 2021
2LQD	Reduced and CO-bound cytochrome P450cam (CYP101A1) 分子名称: CARBON MONOXIDE, Camphor 5-monooxygenase, POTASSIUM ION, ... 著者 Pochapsky, T.C, Pochapsky, S.S, Asciutto, E, Madura, J, Young, M.J. 登録日 2012-03-02 公開日 2012-05-09 最終更新日 2016-04-27 実験手法 SOLUTION NMR 主引用文献 Solution Structural Ensembles of Substrate-Free Cytochrome P450(cam). Biochemistry, 51, 2012
7ANT	Structure of CYP153A from Polaromonas sp. 分子名称: 1,2-ETHANEDIOL, Cytochrome P450, HEME C 著者 Zukic, E, Rowlinson, B, Sharma, M, Hoffman, S, Hauer, B, Grogan, G. 登録日 2020-10-12 公開日 2021-04-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Substrate Anchoring and Flexibility Reduction in CYP153AM.aq Leads to Highly Improved Efficiency toward Octanoic Acid Acs Catalysis, 11, 2021
7AO7	Structure of CYP153A from Polaromonas sp. in complex with octan-1-ol 分子名称: Cytochrome P450, OCTAN-1-OL, PROTOPORPHYRIN IX CONTAINING FE 著者 Zukic, E, Rowlinson, B, Sharma, M, Hoffmann, S, Hauer, B, Grogan, G. 登録日 2020-10-13 公開日 2021-04-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Substrate Anchoring and Flexibility Reduction in CYP153AM.aq Leads to Highly Improved Efficiency toward Octanoic Acid Acs Catalysis, 11, 2021
7AYX	Structure of the cytochrome P450 AryC from Streptomyces roseosporus NRRL 15998 分子名称: Cytochrome P450 113A1, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION 著者 Schneider, S, Schaefers, F, Gulder, T.A.M. 登録日 2020-11-13 公開日 2021-10-27 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Carrier Protein-Free Enzymatic Biaryl Coupling in Arylomycin A2 Assembly and Structure of the Cytochrome P450 AryC. Chemistry, 28, 2022
2NNI	CYP2C8dH complexed with montelukast 分子名称: Cytochrome P450 2C8, MONTELUKAST, PALMITIC ACID, ... 著者 Schoch, G.A, Yano, J.K, Stout, C.D, Johnson, E.F. 登録日 2006-10-24 公開日 2007-10-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid. J.Biol.Chem., 283, 2008
2NNH	CYP2C8dH complexed with 2 molecules of 9-cis retinoic acid 分子名称: (9cis)-retinoic acid, Cytochrome P450 2C8, PALMITIC ACID, ... 著者 Schoch, G.A, Yano, J.K, Stout, C.D, Johnson, E.F. 登録日 2006-10-24 公開日 2007-10-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid. J.Biol.Chem., 283, 2008
2NNJ	CYP2C8dH complexed with felodipine 分子名称: Cytochrome P450 2C8, FELODIPINE, PALMITIC ACID, ... 著者 Schoch, G.A, Yano, J.K, Stout, C.D, Johnson, E.F. 登録日 2006-10-24 公開日 2007-10-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid. J.Biol.Chem., 283, 2008
2NNB	The Q403K mutant heme domain of flavocytochrome P450 BM3 分子名称: Bifunctional P-450:NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE 著者 Clark, J.P, Anderson, J.L.R, Miles, C.S, Mowat, C.G, Reid, G.A, Chapman, S.K. 登録日 2006-10-24 公開日 2007-09-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The Q403K mutant heme domain of flavocytochrome P450 BM3 To be published
7CPP	THE STRUCTURAL BASIS FOR SUBSTRATE-INDUCED CHANGES IN REDOX POTENTIAL AND SPIN EQUILIBRIUM IN CYTOCHROME P450(CAM) 分子名称: CYTOCHROME P450-CAM, NORCAMPHOR, PROTOPORPHYRIN IX CONTAINING FE 著者 Raag, R, Poulos, T.L. 登録日 1990-05-18 公開日 1991-07-15 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The structural basis for substrate-induced changes in redox potential and spin equilibrium in cytochrome P-450CAM. Biochemistry, 28, 1989
7CCF	Mechanism insights on steroselective oxidation of phosphorylated ethylphenols with cytochrome P450 CreJ 分子名称: (3-ethylphenyl) dihydrogen phosphate, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE 著者 Dong, S, Du, L, Li, S.Y, Feng, Y.G. 登録日 2020-06-17 公開日 2021-03-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural Basis for Selective Oxidation of Phosphorylated Ethylphenols by Cytochrome P450 Monooxygenase CreJ. Appl.Environ.Microbiol., 87, 2021
2NZA	Structure and Function Studies of Cytochrome P450 158A1 from Streptomyces coelicolor A3(2) 分子名称: Cytochrome P450 CYP158A1, PROTOPORPHYRIN IX CONTAINING FE 著者 Zhao, B, Waterman, M.R. 登録日 2006-11-22 公開日 2007-07-03 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Different binding modes of two flaviolin substrate molecules in cytochrome P450 158A1 (CYP158A1) compared to CYP158A2. Biochemistry, 46, 2007
7CB9	CYP76AH1/miltiradiene from Salvia miltiorrhiza 分子名称: Ferruginol synthase, Miltiradiene, PROTOPORPHYRIN IX CONTAINING FE 著者 Chang, Z, Chao, S, Mingyue, G. 登録日 2020-06-11 公開日 2021-06-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 CYP76AH1 from Salvia miltiorrhiza To Be Published
7CL9	Androstenedione-bound structure of CYP154C2 from Streptomyces avermitilis in an open conformation 分子名称: 4-ANDROSTENE-3-17-DIONE, Cytochrome P450 hydroxylase, DI(HYDROXYETHYL)ETHER, ... 著者 Xu, L.H, Fushinobu, S. 登録日 2020-07-20 公開日 2021-07-21 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Androstenedione-bound structure of CYP154C2 from Streptomyces avermitilis in an open conformation To Be Published
7CL7	Substrate-free structure of CYP154C2 from Streptomyces avermitilis in an open conformation 分子名称: Cytochrome P450 hydroxylase, DI(HYDROXYETHYL)ETHER, PROTOPORPHYRIN IX CONTAINING FE 著者 Xu, L.H, Fushinobu, S. 登録日 2020-07-20 公開日 2021-07-21 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Substrate-free structure of CYP154C2 in an open conformation To Be Published
7CL8	Testosterone-bound structure of CYP154C2 from Streptomyces avermitilis in an closed conformation 分子名称: Cytochrome P450 hydroxylase, DI(HYDROXYETHYL)ETHER, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Xu, L.H, Fushinobu, S. 登録日 2020-07-20 公開日 2021-07-21 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Improved 2 alpha-Hydroxylation Efficiency of Steroids by CYP154C2 Using Structure-Guided Rational Design. Appl.Environ.Microbiol., 89, 2023
7CVR	Structure of the CYP102A1 Haem Domain with N-Carboxybenzyl-L-Prolyl-L-Phenylalanine in complex with (S)-1-Tetralylamine 分子名称: (1~{S})-1,2,3,4-tetrahydronaphthalen-1-amine, (2S)-3-phenyl-2-[[(2S)-1-phenylmethoxycarbonylpyrrolidin-2-yl]carbonylamino]propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, ... 著者 Stanfield, J.K, Sugimoto, H, Shoji, O. 登録日 2020-08-26 公開日 2021-09-01 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure of the CYP102A1 Haem Domain with N-Carboxybenzyl-L-Prolyl-L-Phenylalanine in complex with (S)-1-Tetralylamine at 1.60 Angstrom Resolution To Be Published
7CX6	Structure of the CYP102A1 Haem Domain with N-(5-Cyclohexyl)valeroyl-L-Phenylalanine in complex with (R)-(+)-1-Phenylethylamine 分子名称: (1R)-1-phenylethanamine, (2~{S})-2-(5-cyclohexylpentanoylamino)-3-phenyl-propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, ... 著者 Stanfield, J.K, Sugimoto, H, Shoji, O. 登録日 2020-09-01 公開日 2021-09-08 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Structure of the CYP102A1 Haem Domain with N-(5-Cyclohexyl)valeroyl-L-Phenylalanine in complex with (R)-(+)-1-Phenylethylamine at 1.69 Angstrom Resolution To Be Published
7CX8	Structure of the CYP102A1 Haem Domain with N-(5-Cyclohexyl)valeroyl-L-Phenylalanine in complex with (R)-1-Tetralylamine 分子名称: (1R)-1,2,3,4-tetrahydronaphthalen-1-amine, (1~{S})-1,2,3,4-tetrahydronaphthalen-1-amine, (2~{S})-2-(5-cyclohexylpentanoylamino)-3-phenyl-propanoic acid, ... 著者 Stanfield, J.K, Sugimoto, H, Shoji, O. 登録日 2020-09-01 公開日 2021-09-08 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure of the CYP102A1 Haem Domain with N-(5-Cyclohexyl)valeroyl-L-Phenylalanine in complex with (R)-1-Tetralylamine at 1.70 Angstrom Resolution To Be Published
7COO	Structure of the CYP102A1 Haem Domain with N-Carboxybenzyl-L-Prolyl-L-Phenylalanine in complex with Cyclohexylamine 分子名称: (2S)-3-phenyl-2-[[(2S)-1-phenylmethoxycarbonylpyrrolidin-2-yl]carbonylamino]propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, CYCLOHEXYLAMMONIUM ION, ... 著者 Stanfield, J.K, Sugimoto, H, Shoji, O. 登録日 2020-08-04 公開日 2021-09-15 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Structure of the CYP102A1 Haem Domain with N-Carboxybenzyl-L-Prolyl-L-Phenylalanine in complex with Cyclohexylamine at 1.49 Angstrom Resolution To Be Published
7CON	Structure of the CYP102A1 Haem Domain with N-{2-[4-(Trifluoromethoxy)phenoxy]}acetoyl-L-Phenylalanine in complex with n-Propylamine 分子名称: (2S)-3-phenyl-2-[2-[4-(trifluoromethyloxy)phenoxy]ethanoylamino]propanoic acid, 3-AMINOPROPANE, Bifunctional cytochrome P450/NADPH--P450 reductase, ... 著者 Stanfield, J.K, Sugimoto, H, Shoji, O. 登録日 2020-08-04 公開日 2021-09-15 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Structure of the CYP102A1 Haem Domain with N-{2-[4-(trifluoromethoxy)phenoxy]}acetoyl-L-phenylalanine in complex with n-propylamine at 1.46 Angstrom Resolution To Be Published
7CKN	Structure of the CYP102A1 Haem Domain with N-{2-[4-(Trifluoromethoxy)phenoxy]}acetoyl-L-Phenylalanine in complex with Isopropylamine 分子名称: (2S)-3-phenyl-2-[2-[4-(trifluoromethyloxy)phenoxy]ethanoylamino]propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, GLYCEROL, ... 著者 Stanfield, J.K, Sugimoto, H, Shoji, O. 登録日 2020-07-17 公開日 2021-09-15 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structure of the CYP102A1 Haem Domain with N-{2-[4-(Trifluoromethoxy)phenoxy]}acetoyl-L-Phenylalanine in complex with Isopropylamine at 1.55 Angstrom Resolution To Be Published
7CP8	Structure of the CYP102A1 Haem Domain with N-(5-Cyclohexyl)valeroyl-L-Phenylalanine in complex with (R)-1-Indanylamine 分子名称: (2~{S})-2-(5-cyclohexylpentanoylamino)-3-phenyl-propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, GLYCEROL, ... 著者 Stanfield, J.K, Sugimoto, H, Shoji, O. 登録日 2020-08-06 公開日 2021-09-15 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Structure of the CYP102A1 Haem Domain with N-(5-Cyclohexyl)valeroyl-L-Phenylalanine in complex with (R)-1-Indanylamine at 1.68 Angstrom Resolution To Be Published
2NZ5	Structure and Function Studies of Cytochrome P450 158A1 from Streptomyces coelicolor A3(2) 分子名称: Cytochrome P450 CYP158A1, PROTOPORPHYRIN IX CONTAINING FE, naphthalene-1,2,4,5,7-pentol 著者 Zhao, B, Lamb, D.C, Kelly, S.L, Waterman, M.R. 登録日 2006-11-22 公開日 2007-07-03 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Different binding modes of two flaviolin substrate molecules in cytochrome P450 158A1 (CYP158A1) compared to CYP158A2. Biochemistry, 46, 2007

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