7CL8

Testosterone-bound structure of CYP154C2 from Streptomyces avermitilis in an closed conformation

Summary for 7CL8

Entry DOI	10.2210/pdb7cl8/pdb
Descriptor	Cytochrome P450 hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, TRIETHYLENE GLYCOL, ... (6 entities in total)
Functional Keywords	cytochrome p450, hydroxylase, testosterone, oxidoreductase
Biological source	Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Total number of polymer chains	1
Total formula weight	46539.74
Authors	Xu, L.H.,Fushinobu, S. (deposition date: 2020-07-20, release date: 2021-07-21, Last modification date: 2023-11-29)
Primary citation	Gao, Q.,Ma, B.,Wang, Q.,Zhang, H.,Fushinobu, S.,Yang, J.,Lin, S.,Sun, K.,Han, B.N.,Xu, L.H. Improved 2 alpha-Hydroxylation Efficiency of Steroids by CYP154C2 Using Structure-Guided Rational Design. Appl.Environ.Microbiol., 89:e0218622-e0218622, 2023 Cited by PubMed: 36847541 DOI: 10.1128/aem.02186-22 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.42 Å)

Structure validation