7BQV
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![BU of 7bqv by Molmil](/molmil-images/mine/7bqv) | Cereblon in complex with SALL4 and (S)-5-hydroxythalidomide | Descriptor: | 2-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-5-oxidanyl-isoindole-1,3-dione, Protein cereblon, SULFATE ION, ... | Authors: | Furihata, H, Miyauchi, Y, Asano, A, Tanokura, M, Miyakawa, T. | Deposit date: | 2020-03-25 | Release date: | 2020-08-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide. Nat Commun, 11, 2020
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7BQU
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![BU of 7bqu by Molmil](/molmil-images/mine/7bqu) | Cereblon in complex with SALL4 and (S)-thalidomide | Descriptor: | Protein cereblon, S-Thalidomide, Sal-like protein 4, ... | Authors: | Furihata, H, Miyauchi, Y, Asano, A, Tanokura, M, Miyakawa, T. | Deposit date: | 2020-03-25 | Release date: | 2020-08-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide. Nat Commun, 11, 2020
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8CUC
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![BU of 8cuc by Molmil](/molmil-images/mine/8cuc) | |
7Y3I
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![BU of 7y3i by Molmil](/molmil-images/mine/7y3i) | Structure of DNA bound SALL4 | Descriptor: | DNA (12-mer), Sal-like protein 4, ZINC ION | Authors: | Ru, W, Xu, C. | Deposit date: | 2022-06-10 | Release date: | 2022-10-26 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif. J.Biol.Chem., 298, 2022
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7Y3K
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![BU of 7y3k by Molmil](/molmil-images/mine/7y3k) | Structure of SALL4 ZFC4 bound with 16 bp AT-rich dsDNA | Descriptor: | DNA (16-mer), Sal-like protein 4, ZINC ION | Authors: | Ru, W, Xu, C. | Deposit date: | 2022-06-11 | Release date: | 2022-10-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif. J.Biol.Chem., 298, 2022
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5XWR
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![BU of 5xwr by Molmil](/molmil-images/mine/5xwr) | Crystal Structure of RBBP4-peptide complex | Descriptor: | Histone-binding protein RBBP4, MET-SER-ARG-ARG-LYS-GLN-ALA-LYS-PRO-GLN-HIS-ILE | Authors: | Jobichen, C, Lui, B.H, Daniel, G.T, Sivaraman, J. | Deposit date: | 2017-06-30 | Release date: | 2018-07-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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7Y3M
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![BU of 7y3m by Molmil](/molmil-images/mine/7y3m) | Structure of SALL4 ZFC1 bound with 16 bp AT-rich dsDNA | Descriptor: | DNA (16-mer), Sal-like protein 4, ZINC ION | Authors: | Ru, W, Xu, C. | Deposit date: | 2022-06-11 | Release date: | 2022-10-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.723 Å) | Cite: | Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif. J.Biol.Chem., 298, 2022
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8U16
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![BU of 8u16 by Molmil](/molmil-images/mine/8u16) | The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-short bound to Pomalidomide | Descriptor: | 1,2-ETHANEDIOL, DNA damage-binding protein 1, Protein cereblon, ... | Authors: | Clifton, M.C, Ma, X, Ornelas, E. | Deposit date: | 2023-08-30 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon. Sci Rep, 13, 2023
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8U15
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![BU of 8u15 by Molmil](/molmil-images/mine/8u15) | The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-short bound to CC-220 | Descriptor: | (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DDB1, Protein cereblon, ... | Authors: | Clifton, M.C, Ma, X, Ornelas, E. | Deposit date: | 2023-08-30 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon. Sci Rep, 13, 2023
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8U17
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![BU of 8u17 by Molmil](/molmil-images/mine/8u17) | The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-long bound to Pomalidomide | Descriptor: | DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ... | Authors: | Clifton, M.C, Ma, X, Ornelas, E. | Deposit date: | 2023-08-30 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon. Sci Rep, 13, 2023
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6UML
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![BU of 6uml by Molmil](/molmil-images/mine/6uml) | Structural Basis for Thalidomide Teratogenicity Revealed by the Cereblon-DDB1-SALL4-Pomalidomide Complex | Descriptor: | DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ... | Authors: | Clayton, T.L, Matyskiela, M.E, Pagarigan, B.E, Tran, E.T, Chamberlain, P.P. | Deposit date: | 2019-10-09 | Release date: | 2020-04-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.58 Å) | Cite: | Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex. Nat.Struct.Mol.Biol., 27, 2020
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