7UYP
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8CS0
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7UYO
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7UYN
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8DW1
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![BU of 8dw1 by Molmil](/molmil-images/mine/8dw1) | Crystal structure of a host-guest complex with 5'-CTTAGTTATAACTAAG-3' | Descriptor: | DNA (5'-D(*CP*TP*TP*AP*GP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*CP*TP*AP*AP*G)-3'), reverse transcriptase | Authors: | Georgiadis, M.M. | Deposit date: | 2022-07-30 | Release date: | 2023-01-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.849 Å) | Cite: | Two distinct rotations of bithiazole DNA intercalation revealed by direct comparison of crystal structures of Co(III)•bleomycin A 2 and B 2 bound to duplex 5'-TAGTT sites. Bioorg.Med.Chem., 77, 2023
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8DW8
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![BU of 8dw8 by Molmil](/molmil-images/mine/8dw8) | Host-guest structure of BLMA2 partially bound to 5'-ATTAGTTATAACTAAT-3' | Descriptor: | BLEOMYCIN A2, DNA (5'-D(*AP*TP*TP*AP*GP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*CP*TP*AP*AP*T)-3'), ... | Authors: | Georgiadis, M.M. | Deposit date: | 2022-07-31 | Release date: | 2023-01-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Two distinct rotations of bithiazole DNA intercalation revealed by direct comparison of crystal structures of Co(III)•bleomycin A 2 and B 2 bound to duplex 5'-TAGTT sites. Bioorg.Med.Chem., 77, 2023
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8WUS
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![BU of 8wus by Molmil](/molmil-images/mine/8wus) | SpCas9-MMLV RT-pegRNA-target DNA complex (termination) | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, DNA (40-MER), DNA (5'-D(*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), ... | Authors: | Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O. | Deposit date: | 2023-10-21 | Release date: | 2024-06-05 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis for pegRNA-guided reverse transcription by a prime editor. Nature, 631, 2024
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8DWM
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![BU of 8dwm by Molmil](/molmil-images/mine/8dwm) | Host-guest complex of bleomycin A2 fully bound to CTTAGTTATAACTAAG | Descriptor: | BLEOMYCIN A2, COBALT (III) ION, DNA (5'-D(*CP*TP*TP*AP*GP*TP*TP*A)-3'), ... | Authors: | Georgiadis, M.M. | Deposit date: | 2022-08-01 | Release date: | 2023-01-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Two distinct rotations of bithiazole DNA intercalation revealed by direct comparison of crystal structures of Co(III)•bleomycin A 2 and B 2 bound to duplex 5'-TAGTT sites. Bioorg.Med.Chem., 77, 2023
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8WUV
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![BU of 8wuv by Molmil](/molmil-images/mine/8wuv) | SpCas9-MMLV RT-pegRNA-target DNA complex (elongation 16-nt) | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), DNA (50-MER), ... | Authors: | Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O. | Deposit date: | 2023-10-21 | Release date: | 2024-06-05 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis for pegRNA-guided reverse transcription by a prime editor. Nature, 631, 2024
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8WUT
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![BU of 8wut by Molmil](/molmil-images/mine/8wut) | SpCas9-MMLV RT-pegRNA-target DNA complex (initiation) | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), DNA (51-MER), ... | Authors: | Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O. | Deposit date: | 2023-10-21 | Release date: | 2024-06-05 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis for pegRNA-guided reverse transcription by a prime editor. Nature, 631, 2024
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8YGJ
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![BU of 8ygj by Molmil](/molmil-images/mine/8ygj) | SpCas9-MMLV RT-pegRNA-target DNA complex (elongation 28-nt) | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(P*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), DNA (51-MER), ... | Authors: | Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O. | Deposit date: | 2024-02-26 | Release date: | 2024-06-05 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis for pegRNA-guided reverse transcription by a prime editor. Nature, 631, 2024
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2N3K
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![BU of 2n3k by Molmil](/molmil-images/mine/2n3k) | Human Brd4 ET domain in complex with MLV Integrase C-term | Descriptor: | Bromodomain-containing protein 4, MLV integrase | Authors: | Crowe, B.L, Foster, M.P. | Deposit date: | 2015-06-03 | Release date: | 2016-03-02 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure of the Brd4 ET domain bound to a C-terminal motif from gamma-retroviral integrases reveals a conserved mechanism of interaction. Proc.Natl.Acad.Sci.USA, 113, 2016
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7JYZ
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![BU of 7jyz by Molmil](/molmil-images/mine/7jyz) | Solution NMR structure and dynamics of human Brd3 ET in complex with MLV IN CTD | Descriptor: | Bromodomain-containing protein 3, Integrase | Authors: | Aiyer, S, Liu, G, Swapna, G.V.T, Hao, J, Ma, L.C, Roth, M.J, Montelione, G.T. | Deposit date: | 2020-09-01 | Release date: | 2021-06-23 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins. Structure, 29, 2021
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