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PDB: 9 results

6VRF
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BU of 6vrf by Molmil
ADP bound TTBK2 kinase domain
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:Chodaparambil, J.V, Marcotte, D.J.
Deposit date:2020-02-07
Release date:2020-06-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms.
Cell Mol Neurobiol, 41, 2021
7Q8Z
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BU of 7q8z by Molmil
Crystal structure of TTBK2 in complex with VNG1.33 (compound 27)
Descriptor: PHOSPHATE ION, Tau-tubulin kinase 2, ~{N}-(4-phenoxyphenyl)-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine
Authors:Chaikuad, A, Nozal, V, Martinez, A, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-11-11
Release date:2022-03-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.
J.Med.Chem., 65, 2022
7O06
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BU of 7o06 by Molmil
Crystal structure of the N-terminal domain of CEP164(1-109) bound to camelid nanobody 10Z
Descriptor: Camelid nanobody 10Z, Centrosomal protein of 164 kDa, SULFATE ION
Authors:e Silva, I.R, van Breugel, M.
Deposit date:2021-03-25
Release date:2021-09-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies.
Structure, 30, 2022
7Q8Y
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BU of 7q8y by Molmil
Crystal structure of TTBK2 in complex with VNG2.73 (compound 42)
Descriptor: PHOSPHATE ION, Tau-tubulin kinase 2, ~{N}-[4-(2-chloranylphenoxy)phenyl]-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine
Authors:Chaikuad, A, Nozal, V, Martinez, A, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-11-11
Release date:2022-03-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.
J.Med.Chem., 65, 2022
7Q90
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BU of 7q90 by Molmil
Crystal structure of TTBK2 in complex with VNG1.63 (compound 32)
Descriptor: PHOSPHATE ION, Tau-tubulin kinase 2, ~{N}-[4-(4-methoxyphenoxy)phenyl]-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine
Authors:Chaikuad, A, Nozal, V, Martinez, A, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-11-11
Release date:2022-03-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.
J.Med.Chem., 65, 2022
7O0S
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BU of 7o0s by Molmil
Crystal structure of the N-terminal domain of CEP164(1-109) bound to camelid nanobody 36Z
Descriptor: Centrosomal protein of 164 kDa, Nanobody 36Z
Authors:e Silva, I.R, van Breugel, M.
Deposit date:2021-03-26
Release date:2021-09-15
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies.
Structure, 30, 2022
6U0K
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BU of 6u0k by Molmil
TTBK2 kinase domain in complex with Compound 1
Descriptor: 4-[3-HYDROXYANILINO]-6,7-DIMETHOXYQUINAZOLINE, GLYCEROL, PHOSPHATE ION, ...
Authors:Marcotte, D.J, Chodaparambil, J.V.
Deposit date:2019-08-14
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.744 Å)
Cite:The crystal structure of the catalytic domain of tau tubulin kinase 2 in complex with a small-molecule inhibitor
Acta Crystallogr.,Sect.F, 76, 2020
7O3B
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BU of 7o3b by Molmil
Crystal structure of the TTBK2-CEP164 complex bound to a camelid nanobody
Descriptor: Nanobody 36Z, Tau-tubulin kinase 2,Centrosomal protein of 164 kDa
Authors:e Silva, I.R, van Breugel, M.
Deposit date:2021-04-01
Release date:2021-09-15
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies.
Structure, 30, 2022
7NWJ
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BU of 7nwj by Molmil
Solution NMR structure of the N-terminal domain of CEP164 (1-109)
Descriptor: Centrosomal protein of 164 kDa
Authors:van Breugel, M, Rutherford, T.J.
Deposit date:2021-03-16
Release date:2021-09-15
Last modified:2024-06-19
Method:SOLUTION NMR
Cite:Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies.
Structure, 30, 2022

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PDB entries from 2024-07-03

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