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PDB: 39 results
6CDO
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BU of 6cdo by Molmil
Structure of vaccine-elicited HIV-1 neutralizing antibody vFP16.02 in complex with HIV-1 fusion peptide residue 512-519
Descriptor: HIV-1 fusion peptide 512-519, SULFATE ION, vFP16.02 Fab heavy chain, ...
Authors:Xu, K, Liu, K, Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6CDM
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BU of 6cdm by Molmil
Structure of vaccine-elicited HIV-1 neutralizing antibody vFP7.04 in complex with HIV-1 fusion peptide residue 512-519
Descriptor: HIV fusion peptide (512-519), vFP7.04 heavy chain, vFP7.04 light chain
Authors:Xu, K, Liu, K, Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.408 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6CDP
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BU of 6cdp by Molmil
Vaccine-elicited HIV-1 neutralizing antibody vFP20.01 in complex with HIV-1 fusion peptide residue 512-519
Descriptor: HIV-1 fusion peptide 512-519, SULFATE ION, vFP20.01 Fab heavy chain, ...
Authors:Xu, K, Liu, K, Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.456 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
8TTW
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BU of 8ttw by Molmil
Cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with temsavir, 8ANC195, and 10-1074
Descriptor: 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Tolbert, W.D, Pozharski, E, Pazgier, M.
Deposit date:2023-08-15
Release date:2023-11-08
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir.
Nat Commun, 14, 2023
5U7M
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BU of 5u7m by Molmil
Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-378806 in Complex with Human Antibodies PGT122 and 35O22 at 3.8 Angstrom
Descriptor: 1-[(2R)-4-(benzenecarbonyl)-2-methylpiperazin-1-yl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Pancera, M, Lai, Y.-T, Kwong, P.D.
Deposit date:2016-12-12
Release date:2017-08-30
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (3.025 Å)
Cite:Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.
Nat. Chem. Biol., 13, 2017
5U7O
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BU of 5u7o by Molmil
Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-626529 in Complex with Human Antibodies PGT122 and 35O22 at 3.8 Angstrom
Descriptor: 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Pancera, M, Lai, Y.-T, Kwong, P.D.
Deposit date:2016-12-12
Release date:2017-08-30
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3.031 Å)
Cite:Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.
Nat. Chem. Biol., 13, 2017
8TKC
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BU of 8tkc by Molmil
CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-b.01 FAB
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP Surface protein gp120, ...
Authors:Pletnev, S, Hoyt, F, Fischer, E, Kwong, P.
Deposit date:2023-07-25
Release date:2024-08-28
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Broad and potent HIV-1 neutralization in fusion peptide-primed SHIV-boosted macaques.
To Be Published
8TL3
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BU of 8tl3 by Molmil
CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-d.01 FAB
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP glycoprotein gp120, ...
Authors:Pletnev, S, Hoyt, F, Fischer, E, Kwong, P.
Deposit date:2023-07-26
Release date:2024-08-28
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Broad and potent HIV-1 neutralization in fusion peptide-primed SHIV-boosted macaques.
To Be Published
4TVP
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BU of 4tvp by Molmil
Crystal Structure of the HIV-1 BG505 SOSIP.664 Env Trimer Ectodomain, Comprising Atomic-Level Definition of Pre-Fusion gp120 and gp41, in Complex with Human Antibodies PGT122 and 35O22
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 Heavy chain, ...
Authors:Pancera, M, Zhou, T, Kwong, P.D.
Deposit date:2014-06-27
Release date:2014-10-08
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure and immune recognition of trimeric pre-fusion HIV-1 Env.
Nature, 514, 2014
8C8T
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BU of 8c8t by Molmil
cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with bNAbs EPTC112 and 3BNC117
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ...
Authors:Baquero, E, Molinos-Albert, L, Mouquet, H.
Deposit date:2023-01-21
Release date:2023-07-05
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Anti-V1/V3-glycan broadly HIV-1 neutralizing antibodies in a post-treatment controller.
Cell Host Microbe, 31, 2023
8TL2
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BU of 8tl2 by Molmil
CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-c.01 FAB
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP Surface protein gp120, ...
Authors:Pletnev, S, Hoyt, F, Fischer, E, Kwong, P.
Deposit date:2023-07-26
Release date:2024-08-28
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Broad and potent HIV-1 neutralization in fusion peptide-primed SHIV-boosted macaques.
To Be Published
8TL4
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BU of 8tl4 by Molmil
CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-e.01 FAB
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP Surface protein gp120, ...
Authors:Pletnev, S, Hoyt, F, Fischer, E, Kwong, P.
Deposit date:2023-07-26
Release date:2024-08-28
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Broad and potent HIV-1 neutralization in fusion peptide-primed SHIV-boosted macaques.
To Be Published
8TQ1
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BU of 8tq1 by Molmil
HIV-1 BG505 Env SOSIP in complex with bovine Fab Bess4 and non-human primate Fab RM20A3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Bovine Bess4 Fab heavy chain, ...
Authors:Ozorowski, G, Lee, W.H, Ward, A.B.
Deposit date:2023-08-06
Release date:2024-08-07
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire.
Plos Pathog., 20, 2024
8TL5
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BU of 8tl5 by Molmil
CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO HERH-c.01 FAB
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP Surface protein gp120, ...
Authors:Pletnev, S, Hoyt, F, Fischer, E, Kwong, P.
Deposit date:2023-07-26
Release date:2024-08-28
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Broad and potent HIV-1 neutralization in fusion peptide-primed SHIV-boosted macaques.
To Be Published
8TNU
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BU of 8tnu by Molmil
Cryo-EM structure of TRNM-b*01 Fab in complex with HIV-1 Env trimer BG505.DS SOSIP
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP Surface protein gp120, ...
Authors:Roark, R.S, Morano, N.C, Shapiro, L.S, Kwong, P.D.
Deposit date:2023-08-02
Release date:2024-08-07
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques.
Cell, 2024
8TO7
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BU of 8to7 by Molmil
Cryo-EM structure of HERH-b*01 Fab in complex with HIV-1 Env trimer BG505.DS SOSIP
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HERH-b*01 heavy chain, ...
Authors:Roark, R.S, Hoyt, F, Hansen, B, Fischer, E, Shapiro, L.S, Kwong, P.D.
Deposit date:2023-08-03
Release date:2024-08-07
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.39 Å)
Cite:Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques.
Cell, 2024
7UGN
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BU of 7ugn by Molmil
Cryo-EM structure of BG24 inferred germline Fabs with germline CDR3s and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 - Class 1
Descriptor: 10-1074 Fab heavy chain, 10-1074 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Dam, K.A, Bjorkman, P.J.
Deposit date:2022-03-25
Release date:2022-10-26
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:HIV-1 CD4-binding site germline antibody-Env structures inform vaccine design.
Nat Commun, 13, 2022
8FYI
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BU of 8fyi by Molmil
Structure of HIV-1 BG505 SOSIP-HT1 in complex with one CD4 molecule
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(6-8)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Fan, C, Dam, K.A, Bjorkman, P.J.
Deposit date:2023-01-26
Release date:2023-10-18
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Intermediate conformations of CD4-bound HIV-1 Env heterotrimers.
Nature, 623, 2023
6CM3
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BU of 6cm3 by Molmil
BG505 SOSIP in complex with sCD4, 17b, 8ANC195
Descriptor: 17b Fab heavy chain, 17b Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Wang, H, Bjorkman, P.J.
Deposit date:2018-03-02
Release date:2018-10-17
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Partially Open HIV-1 Envelope Structures Exhibit Conformational Changes Relevant for Coreceptor Binding and Fusion.
Cell Host Microbe, 24, 2018
6CDI
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BU of 6cdi by Molmil
Cryo-EM structure at 3.6 A resolution of vaccine-elicited antibody vFP16.02 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein 120, ...
Authors:Acharya, P, Xu, K, Liu, K, Carragher, B, Potter, C.S, Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
7L8F
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BU of 7l8f by Molmil
BG505 SOSIP.v5.2(7S) in complex with the polyclonal Fab pAbC-2 from animal Rh.33172 (Wk38 time point)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ...
Authors:Antanasijevic, A, Sewall, L.M, Ward, A.B.
Deposit date:2020-12-31
Release date:2021-08-04
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM.
Nat Commun, 12, 2021
7T9T
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BU of 7t9t by Molmil
Cryo-EM structure of CH235.12 in complex with HIV-1 Env trimer CH505TF.N279K.SOSIP.664 with complex glycans
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Manne, K, Acharya, P.
Deposit date:2021-12-20
Release date:2023-08-16
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM structure of CH235.12 in complex with HIV-1 Env trimer CH505TF.N279K.G458Y.SOSIP.664
To Be Published
6CH7
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BU of 6ch7 by Molmil
XFEL crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and 35O22
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Barnes, C.O, Bjorkman, P.J.
Deposit date:2018-02-22
Release date:2018-05-02
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope.
Nat Commun, 9, 2018
6CDE
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BU of 6cde by Molmil
Cryo-EM structure at 3.8 A resolution of vaccine-elicited antibody vFP20.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein 120, ...
Authors:Acharya, P, Xu, K, Liu, K, Carragher, B, Potter, C.S, Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6DFH
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BU of 6dfh by Molmil
BG505 MD64 N332-GT2 SOSIP trimer in complex with germline-reverted BG18 fragment antigen binding
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ...
Authors:Ozorowski, G, Steichen, J.M, Schief, W.R, Ward, A.B.
Deposit date:2018-05-14
Release date:2019-11-06
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.85 Å)
Cite:A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses.
Science, 366, 2019

 

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