6CH7

XFEL crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and 35O22

Summary for 6CH7

Entry DOI	10.2210/pdb6ch7/pdb
Descriptor	Envelope glycoprotein gp41, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (19 entities in total)
Functional Keywords	env glycoprotein, broadly neutralizing antibodies, immune system
Biological source	Human immunodeficiency virus 1 More
Total number of polymer chains	6
Total formula weight	184316.91
Authors	Barnes, C.O.,Bjorkman, P.J. (deposition date: 2018-02-22, release date: 2018-05-02, Last modification date: 2020-07-29)
Primary citation	Barnes, C.O.,Gristick, H.B.,Freund, N.T.,Escolano, A.,Lyubimov, A.Y.,Hartweger, H.,West, A.P.,Cohen, A.E.,Nussenzweig, M.C.,Bjorkman, P.J. Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope. Nat Commun, 9:1251-1251, 2018 Cited by PubMed: 29593217 DOI: 10.1038/s41467-018-03632-y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.8 Å)

Structure validation