1MDW
 
 | | Crystal Structure of Calcium-Bound Protease Core of Calpain II Reveals the Basis for Intrinsic Inactivation | | Descriptor: | CALCIUM ION, Calpain II, catalytic subunit | | Authors: | Moldoveanu, T, Hosfield, C.M, Lim, D, Jia, Z, Davies, P.L. | | Deposit date: | 2002-08-07 | | Release date: | 2003-04-29 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Calpain silencing by a reversible intrinsic mechanism.
Nat.Struct.Biol., 10, 2003
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3BOW
 | | Structure of M-calpain in complex with Calpastatin | | Descriptor: | CALCIUM ION, Calpain small subunit 1, Calpain-2 catalytic subunit, ... | | Authors: | Hanna, R.A, Campbell, R.L, Davies, P.L. | | Deposit date: | 2007-12-17 | | Release date: | 2008-11-25 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin.
Nature, 456, 2008
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1DF0
 | | Crystal structure of M-Calpain | | Descriptor: | CALPAIN, M-CALPAIN | | Authors: | Hosfield, C.M, Elce, J.S, Davies, P.L, Jia, Z. | | Deposit date: | 1999-11-16 | | Release date: | 2000-06-21 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of calpain reveals the structural basis for Ca(2+)-dependent protease activity and a novel mode of enzyme activation.
EMBO J., 18, 1999
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1QXP
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1U5I
 | | Crystal Structure analysis of rat m-calpain mutant Lys10 Thr | | Descriptor: | Calpain 2, large [catalytic] subunit precursor, Calpain small subunit 1 | | Authors: | Hosfield, C.M, Pal, G.P, Elce, J.S, Jia, Z. | | Deposit date: | 2004-07-27 | | Release date: | 2005-01-18 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.86 Å) | | Cite: | Activation of calpain by Ca2+: roles of the large subunit N-terminal and domain III-IV linker peptides
J.Mol.Biol., 343, 2004
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3DF0
 | | Calcium-dependent complex between m-calpain and calpastatin | | Descriptor: | CALCIUM ION, Calpain small subunit 1, Calpain-2 catalytic subunit, ... | | Authors: | Moldoveanu, T, Gehring, K, Green, D.R. | | Deposit date: | 2008-06-11 | | Release date: | 2008-11-11 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains.
Nature, 456, 2008
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