4WAT
 
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7PHU
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5MI0
 | | A thermally stabilised version of Plasmodium falciparum RH5 | | Descriptor: | MONOCLONAL ANTIBODY 9AD4, Reticulocyte binding-like protein 5,Reticulocyte binding protein 5 | | Authors: | Campeotto, I, Goldenzweig, A, Davey, J, Barfod, L, Marshall, J.M, Silk, S.E, Wright, K.E, Draper, S.J, Higgins, M.K, Fleishman, S.J. | | Deposit date: | 2016-11-27 | | Release date: | 2016-12-28 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | One-step design of a stable variant of the malaria invasion protein RH5 for use as a vaccine immunogen.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6RCV
 | | PfRH5 bound to monoclonal antibodies R5.011 and R5.016 | | Descriptor: | R5.011 heavy chain, R5.011 light chain, R5.016 heavy chain, ... | | Authors: | Alanine, D.W.G, Draper, S.J, Higgins, M.K. | | Deposit date: | 2019-04-11 | | Release date: | 2019-06-26 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (3.582 Å) | | Cite: | Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies.
Cell, 178, 2019
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6RCU
 | | PfRH5 bound to monoclonal antibodies R5.004 and R5.016 | | Descriptor: | R5.004 heavy chain, R5.004 light chain, R5.016 heavy chain, ... | | Authors: | Alanine, D.W.G, Draper, S.J, Higgins, M.K. | | Deposit date: | 2019-04-11 | | Release date: | 2019-06-26 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (4.005 Å) | | Cite: | Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies.
Cell, 178, 2019
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4U0R
 | | Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to monoclonal antibody 9AD4 | | Descriptor: | Monoclonal antibody 9AD4 heavy chain, Monoclonal antibody 9AD4 light chain, Reticulocyte binding protein 5 | | Authors: | Wright, K.E, Hjerrild, K.A, Bartlett, J, Douglas, A.D, Jin, J, Brown, R.E, Ashfield, R, Clemmensen, S.B, de Jongh, W.A, Draper, S.J, Higgins, M.K. | | Deposit date: | 2014-07-14 | | Release date: | 2014-08-13 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies.
Nature, 515, 2014
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4U1G
 | | Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to monoclonal antibody QA1 | | Descriptor: | QA1 monoclonal antibody heavy chain, QA1 monoclonal antibody light chain, Reticulocyte binding protein 5 | | Authors: | Wright, K.E, Hjerrild, K.A, Bartlett, J, Douglas, A.D, Jin, J, Brown, R.E, Ashfield, R, Clemmensen, S.B, de Jongh, W.A, Draper, S.J, Higgins, M.K. | | Deposit date: | 2014-07-15 | | Release date: | 2014-08-13 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies.
Nature, 515, 2014
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8PWX
 | | PfRH5 bound to monoclonal antibody R5.008 | | Descriptor: | GLYCEROL, Reticulocyte-binding protein homolog 5, scFv fragment for antibody R5.008 | | Authors: | Farrell, B, Higgins, M.K. | | Deposit date: | 2023-07-21 | | Release date: | 2024-06-05 | | Last modified: | 2024-12-18 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5.
Cell, 187, 2024
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8QKS
 | | Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to R5.034 | | Descriptor: | Immunoglobulin lambda variable 1-36, R5034HV, Reticulocyte-binding protein-like protein 5 | | Authors: | Wright, N.D, Barrett, J.R, Bradshaw, W.J, Paterson, N.G, MacLean, E.M, Ferreira, L, McHugh, K, Von Delft, F, Koekemoer, L, Draper, S.J. | | Deposit date: | 2023-09-16 | | Release date: | 2024-07-31 | | Last modified: | 2024-09-18 | | Method: | X-RAY DIFFRACTION (3.994 Å) | | Cite: | Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype.
Cell, 187, 2024
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8QKR
 | | Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to R5.251 | | Descriptor: | R5251VHCH, R5251VLCL, Reticulocyte-binding protein-like protein 5 | | Authors: | Wright, N.D, Barrett, J.R, Bradshaw, W.J, Paterson, N.G, MacLean, E.M, Ferreira, L, McHugh, K, Koekemoer, L, Draper, S.J. | | Deposit date: | 2023-09-16 | | Release date: | 2024-07-31 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (3.234 Å) | | Cite: | Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype.
Cell, 187, 2024
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8RZ2
 | | PfRH5 bound to monoclonal antibody R5.034 | | Descriptor: | R5.034 heavy chain, R5.034 light chain, Reticulocyte binding protein 5 | | Authors: | Farrell, B, Higgins, M.K. | | Deposit date: | 2024-02-11 | | Release date: | 2024-07-17 | | Last modified: | 2025-01-29 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5.
Embo Mol Med, 16, 2024
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8PWW
 | | PfRH5 bound to monoclonal antibody MAD8-151 | | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | Authors: | Farrell, B, Higgins, M.K. | | Deposit date: | 2023-07-21 | | Release date: | 2024-06-05 | | Last modified: | 2024-12-18 | | Method: | X-RAY DIFFRACTION (1.945 Å) | | Cite: | Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5.
Cell, 187, 2024
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8PWU
 | | PfRH5 bound to monoclonal antibody MAD10-255 | | Descriptor: | Reticulocyte-binding protein homolog 5, monoclonal antibody MAD10-255 | | Authors: | Farrell, B, Higgins, M.K. | | Deposit date: | 2023-07-21 | | Release date: | 2024-06-05 | | Last modified: | 2024-12-18 | | Method: | X-RAY DIFFRACTION (3.148 Å) | | Cite: | Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5.
Cell, 187, 2024
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8Q5D
 | | PfRH5 bound to monoclonal antibody MAD10-466 | | Descriptor: | Monoclonal antibody MAD10-466 heavy chain, Monoclonal antibody MAD10-466 light chain, Reticulocyte-binding protein homolog 5 | | Authors: | Farrell, B, Higgins, M.K. | | Deposit date: | 2023-08-08 | | Release date: | 2024-06-05 | | Last modified: | 2024-12-18 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5.
Cell, 187, 2024
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8PWV
 | | PfRH5 bound to monoclonal antibody MAD8-502 | | Descriptor: | Reticulocyte-binding protein homolog 5, monoclonal antibody MAD8-502 | | Authors: | Farrell, B, Higgins, M.K. | | Deposit date: | 2023-07-21 | | Release date: | 2024-06-05 | | Last modified: | 2024-12-18 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5.
Cell, 187, 2024
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8CDD
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6MPV
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4U0Q
 | | Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to basigin | | Descriptor: | Basigin, Reticulocyte binding protein 5 | | Authors: | Wright, K.E, Hjerrild, K.A, Bartlett, J, Douglas, A.D, Jin, J, Brown, R.E, Ashfield, R, Clemmensen, S.B, de Jongh, W.A, Draper, S.J, Higgins, M.K. | | Deposit date: | 2014-07-14 | | Release date: | 2014-08-13 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies.
Nature, 515, 2014
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