1TIF
 
 | | TRANSLATION INITIATION FACTOR 3 N-TERMINAL DOMAIN | | Descriptor: | CHLORIDE ION, TRANSLATION INITIATION FACTOR 3, TRIMETHYL LEAD ION | | Authors: | Biou, V, Shu, F, Ramakrishnan, V. | | Deposit date: | 1995-08-16 | | Release date: | 1995-12-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | X-ray crystallography shows that translational initiation factor IF3 consists of two compact alpha/beta domains linked by an alpha-helix.
EMBO J., 14, 1995
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6O6D
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9HFN
 | | Translation-initiation state of human mitochondrial ribosome small subunit (State E) | | Descriptor: | 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... | | Authors: | Finke, A.F, Heinrichs, M, Aibara, S, Richter-Dennerlein, R, Hillen, H.S. | | Deposit date: | 2024-11-18 | | Release date: | 2025-04-23 | | Last modified: | 2025-04-30 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Coupling of ribosome biogenesis and translation initiation in human mitochondria.
Nat Commun, 16, 2025
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7P2E
 | | Human mitochondrial ribosome small subunit in complex with IF3, GMPPMP and streptomycin | | Descriptor: | 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... | | Authors: | Itoh, Y, Khawaja, A, Singh, V, Rorbach, J, Amunts, A. | | Deposit date: | 2021-07-05 | | Release date: | 2022-07-27 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Structure of the mitoribosomal small subunit with streptomycin reveals Fe-S clusters and physiological molecules.
Elife, 11, 2022
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8QRM
 | | mt-SSU assembly intermediate in GTPBP8 knock-out cells, state 3 | | Descriptor: | 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... | | Authors: | Valentin Gese, G, Cipullo, M, Rorbach, J, Hallberg, B.M. | | Deposit date: | 2023-10-09 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.05 Å) | | Cite: | GTPBP8 plays a role in mitoribosome formation in human mitochondria.
Nat Commun, 15, 2024
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5ME0
 | | Structure of the 30S Pre-Initiation Complex 1 (30S IC-1) Stalled by GE81112 | | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Lopez-Alonso, J.P, Fabbretti, A, Kaminishi, T, Iturrioz, I, Brandi, L, Gil Carton, D, Gualerzi, C, Fucini, P, Connell, S. | | Deposit date: | 2016-11-14 | | Release date: | 2017-01-11 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (13.5 Å) | | Cite: | Structure of a 30S pre-initiation complex stalled by GE81112 reveals structural parallels in bacterial and eukaryotic protein synthesis initiation pathways.
Nucleic Acids Res., 45, 2017
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6RW4
 | | Structure of human mitochondrial 28S ribosome in complex with mitochondrial IF3 | | Descriptor: | 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... | | Authors: | Itoh, Y, Khawaja, A, Rorbach, J, Amunts, A. | | Deposit date: | 2019-06-03 | | Release date: | 2020-06-03 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.97 Å) | | Cite: | Distinct pre-initiation steps in human mitochondrial translation.
Nat Commun, 11, 2020
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5ME1
 | | Structure of the 30S Pre-Initiation Complex 2 (30S IC-2) Stalled by GE81112 | | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Lopez-Alonso, J.P, Fabbretti, A, Kaminishi, T, Iturrioz, I, Brandi, L, Gil Carton, D, Gualerzi, C, Fucini, P, Connell, S. | | Deposit date: | 2016-11-14 | | Release date: | 2017-01-11 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (13.5 Å) | | Cite: | Structure of a 30S pre-initiation complex stalled by GE81112 reveals structural parallels in bacterial and eukaryotic protein synthesis initiation pathways.
Nucleic Acids Res., 45, 2017
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8JSH
 | | Structure of the 30S-body-IF3 complex from Escherichia coli | | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S15, 30S ribosomal protein S16, ... | | Authors: | Uday, A.B, Mishra, R.K, Hussain, T. | | Deposit date: | 2023-06-20 | | Release date: | 2024-01-24 | | Last modified: | 2024-12-18 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Initiation factor 3 bound to the 30S ribosomal subunit in an initial step of translation.
Proteins, 93, 2025
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8JSG
 | | Structure of the 30S-IF3 complex from Escherichia coli | | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S16, Small ribosomal subunit protein bS18, ... | | Authors: | Uday, A.B, Mishra, R.K, Hussain, T. | | Deposit date: | 2023-06-20 | | Release date: | 2024-02-21 | | Last modified: | 2024-12-18 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Initiation factor 3 bound to the 30S ribosomal subunit in an initial step of translation.
Proteins, 93, 2025
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6RW5
 | | Structure of human mitochondrial 28S ribosome in complex with mitochondrial IF2 and IF3 | | Descriptor: | 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... | | Authors: | Itoh, Y, Khawaja, A, Rorbach, J, Amunts, A. | | Deposit date: | 2019-06-03 | | Release date: | 2020-06-03 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | Distinct pre-initiation steps in human mitochondrial translation.
Nat Commun, 11, 2020
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6NF8
 | | Structure of human mitochondrial translation initiation factor 3 bound to the small ribosomal subunit -Class I | | Descriptor: | 28S ribosomal RNA, mitochondria, 28S ribosomal protein S10, ... | | Authors: | Sharma, M, Koripella, R, Agrawal, R. | | Deposit date: | 2018-12-19 | | Release date: | 2019-02-27 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.48 Å) | | Cite: | Structure of Human Mitochondrial Translation Initiation Factor 3 Bound to the Small Ribosomal Subunit.
iScience, 12, 2019
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6NEQ
 | | Structure of human mitochondrial translation initiation factor 3 bound to the small ribosomal subunit-Class-II | | Descriptor: | 28S ribosomal RNA, mitochondrial, 28S ribosomal protein S10, ... | | Authors: | Sharma, M, Koripella, R, Agrawal, R. | | Deposit date: | 2018-12-18 | | Release date: | 2019-02-27 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.32 Å) | | Cite: | Structure of Human Mitochondrial Translation Initiation Factor 3 Bound to the Small Ribosomal Subunit.
iScience, 12, 2019
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9FDA
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9FCO
 | | Structure of E. coli 30S-IF1-IF3-mRNA-Kasugamycin complex | | Descriptor: | (1S,2R,3S,4R,5S,6S)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL 2-AMINO-4-{[CARBOXY(IMINO)METHYL]AMINO}-2,3,4,6-TETRADEOXY-ALPHA-D-ARABINO-HEXOPYRANOSIDE, 16S rRNA, MAGNESIUM ION, ... | | Authors: | Safdari, H.A, Wilson, D.N. | | Deposit date: | 2024-05-15 | | Release date: | 2025-03-19 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | The translation inhibitors kasugamycin, edeine and GE81112 target distinct steps during 30S initiation complex formation.
Nat Commun, 16, 2025
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9G06
 | | Structure of 30S-IF1-IF3-mRNA-fMet-tRNA-GE81112A complex | | Descriptor: | (2S,3S)-2-[[(2S)-2-[[(2S,4S)-5-aminocarbonyloxy-4-oxidanyl-2-[[(2S,3R)-3-oxidanylpiperidin-2-yl]carbonylamino]pentanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-(2-chloranyl-1H-imidazol-4-yl)-3-oxidanyl-propanoic acid, 16S ribosomal RNA, MAGNESIUM ION, ... | | Authors: | Safdari, H.A, Morici, M, Wilson, D.N. | | Deposit date: | 2024-07-07 | | Release date: | 2025-03-19 | | Method: | ELECTRON MICROSCOPY (2.85 Å) | | Cite: | The translation inhibitors kasugamycin, edeine and GE81112 target distinct steps during 30S initiation complex formation.
Nat Commun, 16, 2025
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9FIB
 | | Structure of 30S-IF1-IF3-mRNA-GE81112A complex | | Descriptor: | (2S,3S)-2-[[(2S)-2-[[(2S,4S)-5-aminocarbonyloxy-4-oxidanyl-2-[[(2S,3R)-3-oxidanylpiperidin-2-yl]carbonylamino]pentanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-(2-chloranyl-1H-imidazol-4-yl)-3-oxidanyl-propanoic acid, 16S rRNA, MAGNESIUM ION, ... | | Authors: | Safdari, H.A, Morici, M, Wilson, D.N. | | Deposit date: | 2024-05-29 | | Release date: | 2025-03-19 | | Method: | ELECTRON MICROSCOPY (2.3 Å) | | Cite: | The translation inhibitors kasugamycin, edeine and GE81112 target distinct steps during 30S initiation complex formation.
Nat Commun, 16, 2025
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9HFM
 | | Translation-initiation state of human mitochondrial ribosome small subunit (State D) | | Descriptor: | 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... | | Authors: | Finke, A.F, Heinrichs, M, Aibara, S, Richter-Dennerlein, R, Hillen, H.S. | | Deposit date: | 2024-11-18 | | Release date: | 2025-04-23 | | Last modified: | 2025-04-30 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Coupling of ribosome biogenesis and translation initiation in human mitochondria.
Nat Commun, 16, 2025
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5LMT
 | | Structure of bacterial 30S-IF1-IF3-mRNA-tRNA translation pre-initiation complex(state-3) | | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Hussain, T, Llacer, J.L, Wimberly, B.T, Ramakrishnan, V. | | Deposit date: | 2016-08-01 | | Release date: | 2016-10-05 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (4.15 Å) | | Cite: | Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation.
Cell, 167, 2016
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5LMR
 | | Structure of bacterial 30S-IF1-IF3-mRNA-tRNA translation pre-initiation complex(state-2B) | | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Hussain, T, Llacer, J.L, Wimberly, B.T, Ramakrishnan, V. | | Deposit date: | 2016-08-01 | | Release date: | 2016-10-05 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (4.45 Å) | | Cite: | Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation.
Cell, 167, 2016
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5LMQ
 | | Structure of bacterial 30S-IF1-IF3-mRNA-tRNA translation pre-initiation complex, open form (state-2A) | | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Hussain, T, Llacer, J.L, Wimberly, B.T, Ramakrishnan, V. | | Deposit date: | 2016-08-01 | | Release date: | 2016-10-05 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation.
Cell, 167, 2016
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5LMO
 | | Structure of bacterial 30S-IF1-IF3-mRNA translation pre-initiation complex (state-1B) | | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Hussain, T, Llacer, J.L, Wimberly, B.T, Ramakrishnan, V. | | Deposit date: | 2016-08-01 | | Release date: | 2016-10-05 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation.
Cell, 167, 2016
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5LMV
 | | Structure of bacterial 30S-IF1-IF2-IF3-mRNA-tRNA translation pre-initiation complex(state-III) | | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Hussain, T, Llacer, J.L, Wimberly, B.T, Ramakrishnan, V. | | Deposit date: | 2016-08-01 | | Release date: | 2016-10-05 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (4.9 Å) | | Cite: | Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation.
Cell, 167, 2016
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5LMP
 | | Structure of bacterial 30S-IF1-IF3-mRNA translation pre-initiation complex (state-1C) | | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Hussain, T, Llacer, J.L, Wimberly, B.T, Ramakrishnan, V. | | Deposit date: | 2016-08-01 | | Release date: | 2016-10-05 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (5.35 Å) | | Cite: | Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation.
Cell, 167, 2016
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5LMU
 | | Structure of bacterial 30S-IF3-mRNA-tRNA translation pre-initiation complex, closed form (state-4) | | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Hussain, T, Llacer, J.L, Wimberly, B.T, Ramakrishnan, V. | | Deposit date: | 2016-08-01 | | Release date: | 2016-10-05 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation.
Cell, 167, 2016
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