4ZHK
 
 | | Crystal structure of RPE65 in complex with MB-002 | | Descriptor: | (1R)-1-[3-(cyclohexylmethoxy)phenyl]propane-1,3-diol, (1S)-1-[3-(cyclohexylmethoxy)phenyl]propane-1,3-diol, FE (II) ION, ... | | Authors: | Kiser, P.D, Palczewski, K. | | Deposit date: | 2015-04-25 | | Release date: | 2015-05-27 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Molecular pharmacodynamics of emixustat in protection against retinal degeneration.
J.Clin.Invest., 125, 2015
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6VCF
 | | Crystal structure of Nitrosotalea devanaterra carotenoid cleavage dioxygenase, iron form | | Descriptor: | BICARBONATE ION, CHLORIDE ION, FE (II) ION, ... | | Authors: | Daruwalla, A, Shi, W, Kiser, P.D. | | Deposit date: | 2019-12-20 | | Release date: | 2020-07-08 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.687 Å) | | Cite: | Structural basis for carotenoid cleavage by an archaeal carotenoid dioxygenase.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6VCH
 | | Crystal structure of Nitrosotalea devanaterra carotenoid cleavage dioxygenase in complex with 3-hydroxy-beta-apo-14'-carotenal | | Descriptor: | (2E,4E,6E,8E,10E)-11-[(4R)-4-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl]-5,9-dimethylundeca-2,4,6,8,10-pentaenal, CHLORIDE ION, COBALT (II) ION, ... | | Authors: | Daruwalla, A, Shi, W, Kiser, P.D. | | Deposit date: | 2019-12-20 | | Release date: | 2020-07-08 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structural basis for carotenoid cleavage by an archaeal carotenoid dioxygenase.
Proc.Natl.Acad.Sci.USA, 117, 2020
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8SRL
 | | Crystal structure of T151V CAO1 in complex with piceatannol | | Descriptor: | BENZOIC ACID, Carotenoid oxygenase, FE (II) ION, ... | | Authors: | Kiser, P.D. | | Deposit date: | 2023-05-05 | | Release date: | 2024-05-15 | | Last modified: | 2025-05-07 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Spectroscopy and crystallography define carotenoid oxygenases as a new subclass of mononuclear non-heme Fe II enzymes.
J.Biol.Chem., 301, 2025
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3FSN
 | | Crystal structure of RPE65 at 2.14 angstrom resolution | | Descriptor: | FE (II) ION, Retinal pigment epithelium-specific 65 kDa protein, TETRAETHYLENE GLYCOL | | Authors: | Kiser, P.D, Lodowski, D.T, Palczewski, K. | | Deposit date: | 2009-01-11 | | Release date: | 2009-09-29 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Crystal structure of native RPE65, the retinoid isomerase of the visual cycle.
Proc.Natl.Acad.Sci.USA, 106, 2009
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8DOC
 | | Crystal structure of RPE65 in complex with compound 16e and palmitate | | Descriptor: | (1R)-1-[3-(cyclohexylmethoxy)phenyl]-3-(methylamino)propan-1-ol, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, FE (II) ION, ... | | Authors: | Bassetto, M, Kiser, P.D. | | Deposit date: | 2022-07-12 | | Release date: | 2023-05-24 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Tuning the Metabolic Stability of Visual Cycle Modulators through Modification of an RPE65 Recognition Motif.
J.Med.Chem., 66, 2023
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8FU5
 | | Crystal structure of Fe-CAO1 in complex with piceatannol | | Descriptor: | BENZOIC ACID, Carotenoid oxygenase, FE (II) ION, ... | | Authors: | Kiser, P.D. | | Deposit date: | 2023-01-16 | | Release date: | 2024-08-07 | | Last modified: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Spectroscopy and crystallography define carotenoid oxygenases as a new subclass of mononuclear non-heme Fe II enzymes.
J.Biol.Chem., 2025
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7QR6
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6VCG
 | | Crystal structure of Nitrosotalea devanaterra carotenoid cleavage dioxygenase, cobalt form | | Descriptor: | CHLORIDE ION, COBALT (II) ION, SODIUM ION, ... | | Authors: | Daruwalla, A, Shi, W, Kiser, P.D. | | Deposit date: | 2019-12-20 | | Release date: | 2020-07-08 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for carotenoid cleavage by an archaeal carotenoid dioxygenase.
Proc.Natl.Acad.Sci.USA, 117, 2020
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4RYZ
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8FTY
 | | Crystal structure of the carotenoid isomerooxygenase, NinaB | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, CHLORIDE ION, ... | | Authors: | Kiser, P.D, Solano, Y.J. | | Deposit date: | 2023-01-14 | | Release date: | 2024-01-17 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore.
Nat.Chem.Biol., 20, 2024
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8FU2
 | | Crystal structure of T151G CAO1 in complex with piceatannol | | Descriptor: | BENZOIC ACID, Carotenoid oxygenase, FE (II) ION, ... | | Authors: | Kiser, P.D. | | Deposit date: | 2023-01-16 | | Release date: | 2024-08-07 | | Last modified: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Spectroscopy and crystallography define carotenoid oxygenases as a new subclass of mononuclear non-heme Fe II enzymes.
J.Biol.Chem., 2025
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4RSC
 | | Crystal structure of RPE65 in complex with emixustat and palmitate | | Descriptor: | (1R)-3-amino-1-[3-(cyclohexylmethoxy)phenyl]propan-1-ol, FE (II) ION, PALMITIC ACID, ... | | Authors: | Kiser, P.D, Shi, W, Palczewski, K. | | Deposit date: | 2014-11-07 | | Release date: | 2015-04-15 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Catalytic mechanism of a retinoid isomerase essential for vertebrate vision.
Nat.Chem.Biol., 11, 2015
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3KVC
 | | Crystal structure of bovine RPE65 at 1.9 angstrom resolution | | Descriptor: | FE (II) ION, Retinoid isomerohydrolase | | Authors: | Kiser, P.D, Lodowski, D.T, Golczak, M, Palczewski, K. | | Deposit date: | 2009-11-29 | | Release date: | 2010-02-02 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Importance of membrane structural integrity for RPE65 retinoid isomerization activity.
J.Biol.Chem., 285, 2010
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2BIW
 | | Crystal structure of apocarotenoid cleavage oxygenase from Synechocystis, native enzyme | | Descriptor: | (3R)-3-HYDROXY-8'-APOCAROTENOL, APOCAROTENOID-CLEAVING OXYGENASE, FE (III) ION | | Authors: | Kloer, D.P, Ruch, S, Al-Babili, S, Beyer, P, Schulz, G.E. | | Deposit date: | 2005-01-26 | | Release date: | 2005-04-14 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.39 Å) | | Cite: | The Structure of a Retinal-Forming Carotenoid Oxygenase
Science, 308, 2005
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7T8P
 | | CRYSTAL STRUCTURE OF T151V CAO1 | | Descriptor: | CHLORIDE ION, Carotenoid oxygenase 1, FE (II) ION | | Authors: | Daruwalla, A, Kiser, P.D. | | Deposit date: | 2021-12-16 | | Release date: | 2023-07-05 | | Last modified: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Spectroscopy and crystallography define carotenoid oxygenases as a new subclass of mononuclear non-heme Fe II enzymes.
J.Biol.Chem., 2025
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7T8Q
 | | CRYSTAL STRUCTURE OF T151G CAO1 | | Descriptor: | CHLORIDE ION, Carotenoid oxygenase 1, FE (II) ION | | Authors: | Daruwalla, A, Kiser, P.D. | | Deposit date: | 2021-12-16 | | Release date: | 2023-07-05 | | Last modified: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Spectroscopy and crystallography define carotenoid oxygenases as a new subclass of mononuclear non-heme Fe II enzymes.
J.Biol.Chem., 2025
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4OU8
 | | Crystal structure of apocarotenoid oxygenase in the presence of C8E6 | | Descriptor: | Apocarotenoid-15,15'-oxygenase, CHLORIDE ION, FE (II) ION | | Authors: | Sui, X, Shi, W, Palczewski, K, Kiser, P.D. | | Deposit date: | 2014-02-15 | | Release date: | 2014-03-19 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Analysis of Carotenoid Isomerase Activity in a Prototypical Carotenoid Cleavage Enzyme, Apocarotenoid Oxygenase (ACO).
J.Biol.Chem., 289, 2014
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2BIX
 | | Crystal structure of apocarotenoid cleavage oxygenase from Synechocystis, Fe-free apoenzyme | | Descriptor: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, APOCAROTENOID-CLEAVING OXYGENASE, GLYCEROL | | Authors: | Kloer, D.P, Ruch, S, Al-Babili, S, Beyer, P, Schulz, G.E. | | Deposit date: | 2005-01-26 | | Release date: | 2005-04-14 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | The Structure of a Retinal-Forming Carotenoid Oxygenase
Science, 308, 2005
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3NPE
 | | Structure of VP14 in complex with oxygen | | Descriptor: | 1,4-DIETHYLENE DIOXIDE, 9-cis-epoxycarotenoid dioxygenase 1, chloroplastic, ... | | Authors: | Messing, S.A, Gabelli, S.B, Amzel, L.M. | | Deposit date: | 2010-06-28 | | Release date: | 2010-11-10 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural insights into maize viviparous14, a key enzyme in the biosynthesis of the phytohormone abscisic acid.
Plant Cell, 22, 2010
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6B86
 | | 2.2A Crystal Structure of Co-CAO1 | | Descriptor: | COBALT (II) ION, Carotenoid oxygenase 1 | | Authors: | Hill, H.E, Kiser, P.D. | | Deposit date: | 2017-10-05 | | Release date: | 2018-07-04 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Preparation and characterization of metal-substituted carotenoid cleavage oxygenases.
J. Biol. Inorg. Chem., 23, 2018
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4OU9
 | | Crystal structure of apocarotenoid oxygenase in the presence of Triton X-100 | | Descriptor: | Apocarotenoid-15,15'-oxygenase, CHLORIDE ION, FE (II) ION | | Authors: | Sui, X, Palczewski, K, Kiser, P.D. | | Deposit date: | 2014-02-15 | | Release date: | 2014-03-19 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Analysis of Carotenoid Isomerase Activity in a Prototypical Carotenoid Cleavage Enzyme, Apocarotenoid Oxygenase (ACO).
J.Biol.Chem., 289, 2014
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6BIG
 | | Crystal structure of cobalt-substituted Synechocystis ACO | | Descriptor: | Apocarotenoid-15,15'-oxygenase, CHLORIDE ION, COBALT (II) ION | | Authors: | Sui, X, Shi, W, Kiser, P.D. | | Deposit date: | 2017-11-02 | | Release date: | 2018-07-04 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | Preparation and characterization of metal-substituted carotenoid cleavage oxygenases.
J. Biol. Inorg. Chem., 23, 2018
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5U8Z
 | | Structure of Fe-CAO1 in complex with beta-fluororesveratrol | | Descriptor: | 5-[(Z)-2-fluoro-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol, CHLORIDE ION, Carotenoid oxygenase 1, ... | | Authors: | Sui, X, Palczewski, K, Kiser, P.D. | | Deposit date: | 2016-12-15 | | Release date: | 2017-05-31 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center.
Biochemistry, 56, 2017
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5U8Y
 | | Crystal structure of Co-CAO1 | | Descriptor: | COBALT (II) ION, Carotenoid oxygenase 1 | | Authors: | Sui, X, Palczewski, K, Banerjee, S, Kiser, P.D. | | Deposit date: | 2016-12-15 | | Release date: | 2017-05-31 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center.
Biochemistry, 56, 2017
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