5D53
 
 | | In meso in situ serial X-ray crystallography structure of insulin at 100 K | | Descriptor: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Insulin A chain, Insulin B chain, ... | | Authors: | Huang, C.-Y, Olieric, V, Diederichs, K, Wang, M, Caffrey, M. | | Deposit date: | 2015-08-10 | | Release date: | 2016-01-13 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures.
Acta Crystallogr D Struct Biol, 72, 2016
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8Z4B
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2OMI
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6OR0
 | | Crystal structure of Insulin from Non-merohedrally twinned crystals | | Descriptor: | Insulin chain A, Insulin chain B | | Authors: | Sevvana, M, Ruf, M, Uson, I, Sheldrick, G.M, Herbst-Irmer, R. | | Deposit date: | 2019-04-29 | | Release date: | 2019-12-11 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Non-merohedral twinning: from minerals to proteins.
Acta Crystallogr D Struct Biol, 75, 2019
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2EFA
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6X4X
 | | B24Y DKP insulin | | Descriptor: | Insulin, Insulin chain A | | Authors: | Weiss, M.A, Yang, Y. | | Deposit date: | 2020-05-24 | | Release date: | 2020-08-05 | | Last modified: | 2024-11-20 | | Method: | SOLUTION NMR | | Cite: | Evolution of insulin at the edge of foldability and its medical implications.
Proc.Natl.Acad.Sci.USA, 117, 2020
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7ELJ
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8GSG
 | | T3R3 form of Human insulin with single Zn | | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | Authors: | Zhu, Z.L. | | Deposit date: | 2022-09-06 | | Release date: | 2023-03-15 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | T3R3 insulin with single Zn
To Be Published
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7INS
 | | STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z | | Descriptor: | GENERAL PROTAMINE CHAIN, INSULIN (CHAIN A), INSULIN (CHAIN B), ... | | Authors: | Balschmidt, P, Hansen, F.B, Dodson, E, Dodson, G, Korber, F. | | Deposit date: | 1991-09-03 | | Release date: | 1994-01-31 | | Last modified: | 2025-02-12 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of porcine insulin cocrystallized with clupeine Z.
Acta Crystallogr.,Sect.B, 47, 1991
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2ZPP
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4GBI
 | | Crystal structure of aspart insulin at pH 6.5 | | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | Authors: | Lima, L.M.T.R, Favero-Retto, M.P, Palmieri, L.C. | | Deposit date: | 2012-07-27 | | Release date: | 2013-06-12 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.502 Å) | | Cite: | A T3R3 hexamer of the human insulin variant B28Asp.
Biophys.Chem., 173, 2013
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4GBL
 | | Crystal structure of aspart insulin at pH 8.5 | | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | Authors: | Lima, L.M.T.R, Favero-Retto, M.P, Palmieri, L.C. | | Deposit date: | 2012-07-27 | | Release date: | 2013-06-12 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A T3R3 hexamer of the human insulin variant B28Asp.
Biophys.Chem., 173, 2013
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4XC4
 | | Insulin co-crystallizes in the presence of it beta-cell chaperone sulfatide | | Descriptor: | CHLORIDE ION, Insulin, SODIUM ION, ... | | Authors: | Bracey, A.W, Magis, A.T, Buschard, K, Osterbye, T, Bailey, K.M, Ostrov, D.A. | | Deposit date: | 2014-12-17 | | Release date: | 2015-02-11 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.499 Å) | | Cite: | Insulin co-crystallizes in the presence of it beta-cell chaperone sulfatide
To Be Published
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2ZP6
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3AIY
 | | R6 HUMAN INSULIN HEXAMER (SYMMETRIC), NMR, REFINED AVERAGE STRUCTURE | | Descriptor: | PHENOL, PROTEIN (INSULIN) | | Authors: | O'Donoghue, S.I, Chang, X, Abseher, R, Nilges, M, Led, J.J. | | Deposit date: | 1998-12-29 | | Release date: | 2000-02-28 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | Unraveling the symmetry ambiguity in a hexamer: calculation of the R6 human insulin structure.
J.Biomol.NMR, 16, 2000
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5L3M
 | | D11 bound [S39_PQ]-IGF-II | | Descriptor: | Insulin-like growth factor II | | Authors: | Hexnerova, R. | | Deposit date: | 2016-05-23 | | Release date: | 2016-08-10 | | Last modified: | 2024-10-23 | | Method: | SOLUTION NMR | | Cite: | Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain.
J.Biol.Chem., 291, 2016
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6O17
 | | Recombinant Human Insulin | | Descriptor: | Insulin chain A, Insulin chain B | | Authors: | Reyes-Grajeda, J.P. | | Deposit date: | 2019-02-18 | | Release date: | 2020-02-26 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | Human WT insulin
To Be Published
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4P65
 | | Crystal structure of an cyclohexylalanine substituted insulin analog. | | Descriptor: | CHLORIDE ION, Insulin, PHENOL, ... | | Authors: | Pandyarajan, V, Wan, Z, Weiss, M.A. | | Deposit date: | 2014-03-21 | | Release date: | 2014-10-22 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Aromatic Anchor at an Invariant Hormone-Receptor Interface: FUNCTION OF INSULIN RESIDUE B24 WITH APPLICATION TO PROTEIN DESIGN.
J.Biol.Chem., 289, 2014
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9IBB
 | | Rhombohedral crystalline form of human insulin complexed with m-cresol | | Descriptor: | GLYCEROL, Insulin A chain, Insulin B chain, ... | | Authors: | Papaefthymiou, C, Nanao, M.H, Margiolaki, I, Kontarinis, A, Kafetzi, S, Konstantopoulos, M, Koutoulas, D. | | Deposit date: | 2025-02-12 | | Release date: | 2025-10-29 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Exploring humidity effects on polycrystalline human insulin ligand complexes:preliminary crystallographic insights
J.Appl.Crystallogr., 2025
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6NWV
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9INS
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4RXW
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3BXQ
 | | The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition | | Descriptor: | ZINC ION, insulin A chain, insulin B chain | | Authors: | Wan, Z.L, Huang, K, Hu, S.Q, Whittaker, J, Weiss, M.A. | | Deposit date: | 2008-01-14 | | Release date: | 2008-05-20 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition.
J.Biol.Chem., 283, 2008
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1EV6
 | | Structure of the monoclinic form of the M-cresol/insulin R6 hexamer | | Descriptor: | CHLORIDE ION, INSULIN, M-CRESOL, ... | | Authors: | Smith, G.D, Ciszak, E, Magrum, L.A, Pangborn, W.A, Blessing, R.H. | | Deposit date: | 2000-04-19 | | Release date: | 2000-12-04 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | R6 Hexameric Insulin Complexed with m-Cresol or Resorcinol
Biochem.Biophys.Res.Commun., 56, 2000
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1QIZ
 | | HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR COMPLEXED WITH RESORCINOL | | Descriptor: | CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... | | Authors: | Tang, L, Whittingham, J.L, Verma, C.S, Caves, L.S.D, Dodson, G.G. | | Deposit date: | 1999-06-18 | | Release date: | 1999-06-22 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Consequences of the B5 Histidine --> Tyrosine Mutation in Human Insulin Characterized by X-Ray Crystallography and Conformational Analysis.
Biochemistry, 38, 1999
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