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PDB: 4 results
5DJ4
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BU of 5dj4 by Molmil
Leucine-bound Sestrin2 from Homo sapiens
Descriptor: LEUCINE, Sestrin-2
Authors:Saxton, R.A, Knockenhauer, K.E, Schwartz, T.U.
Deposit date:2015-09-01
Release date:2015-11-25
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.697 Å)
Cite:Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.
Science, 351, 2016
5T0N
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BU of 5t0n by Molmil
Pseudo-apo structure of Sestrin2 at 3.0 angstrom resolution
Descriptor: LEUCINE, Sestrin-2
Authors:Saxton, R.A, Knockenhauer, K.E, Schwartz, T.U.
Deposit date:2016-08-16
Release date:2016-10-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.004 Å)
Cite:The apo-structure of the leucine sensor Sestrin2 is still elusive.
Sci.Signal., 9, 2016
6N0M
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BU of 6n0m by Molmil
CRYSTAL STRUCTURE OF SESTRIN2 IN COMPLEX WITH NV-0005138
Descriptor: 4-(difluoromethyl)-L-leucine, Sestrin-2
Authors:O'Neill, D.
Deposit date:2018-11-07
Release date:2019-04-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Discovery of NV-5138, the first selective Brain mTORC1 activator.
Sci Rep, 9, 2019
5CUF
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BU of 5cuf by Molmil
X-ray crystal structure of SeMet human Sestrin2
Descriptor: Sestrin-2
Authors:Kim, H, An, S, Ro, S.-H, Lee, J.H, Cho, U.-S.
Deposit date:2015-07-24
Release date:2016-01-13
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains.
Nat Commun, 6, 2015

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