1M4Z
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![BU of 1m4z by Molmil](/molmil-images/mine/1m4z) | Crystal structure of the N-terminal BAH domain of Orc1p | Descriptor: | MANGANESE (II) ION, ORIGIN RECOGNITION COMPLEX SUBUNIT 1 | Authors: | Zhang, Z, Hayashi, M.K, Merkel, O, Stillman, B, Xu, R.-M. | Deposit date: | 2002-07-05 | Release date: | 2002-09-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure and function of the BAH-containing domain of Orc1p in epigenetic silencing. EMBO J., 21, 2002
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7TJH
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![BU of 7tjh by Molmil](/molmil-images/mine/7tjh) | S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 1) with flexible Orc6 N-terminal domain | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ... | Authors: | Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. | Deposit date: | 2022-01-16 | Release date: | 2022-10-05 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
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1ZBX
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![BU of 1zbx by Molmil](/molmil-images/mine/1zbx) | Crystal structure of a Orc1p-Sir1p complex | Descriptor: | Origin recognition complex subunit 1, Regulatory protein SIR1 | Authors: | Hsu, H.C, Stillman, B, Xu, R.M. | Deposit date: | 2005-04-09 | Release date: | 2005-06-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for origin recognition complex 1 protein-silence information regulator 1 protein interaction in epigenetic silencing Proc.Natl.Acad.Sci.USA, 102, 2005
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7TJF
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![BU of 7tjf by Molmil](/molmil-images/mine/7tjf) | S. cerevisiae ORC bound to 84 bp ARS1 DNA | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA, 84 bp ARS1, ... | Authors: | Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. | Deposit date: | 2022-01-16 | Release date: | 2023-01-18 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
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7TJK
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![BU of 7tjk by Molmil](/molmil-images/mine/7tjk) | S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 2) with docked Orc6 N-terminal domain | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ... | Authors: | Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. | Deposit date: | 2022-01-16 | Release date: | 2022-10-05 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
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7TJJ
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![BU of 7tjj by Molmil](/molmil-images/mine/7tjj) | S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 1) with docked Orc6 N-terminal domain | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ... | Authors: | Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. | Deposit date: | 2022-01-16 | Release date: | 2022-10-05 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
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7TJI
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![BU of 7tji by Molmil](/molmil-images/mine/7tji) | S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 2) with flexible Orc6 N-terminal domain | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ... | Authors: | Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. | Deposit date: | 2022-01-16 | Release date: | 2022-10-05 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
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1ZHI
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![BU of 1zhi by Molmil](/molmil-images/mine/1zhi) | Complex of the S. cerevisiae Orc1 and Sir1 interacting domains | Descriptor: | Origin recognition complex subunit 1, Regulatory protein SIR1 | Authors: | Hou, Z, Bernstein, D.A, Fox, C.A, Keck, J.L. | Deposit date: | 2005-04-25 | Release date: | 2005-06-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis of the Sir1-origin recognition complex interaction in transcriptional silencing. Proc.Natl.Acad.Sci.Usa, 102, 2005
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5ZR1
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![BU of 5zr1 by Molmil](/molmil-images/mine/5zr1) | Saccharomyces Cerevisiae Origin Recognition Complex Bound to a 72-bp Origin DNA containing ACS and B1 element | Descriptor: | 72bp-oring DNA, ACS305, A-rich, ... | Authors: | Li, N, Lam, W.H, Zhai, Y, Cheng, J, Cheng, E, Zhao, Y, Gao, N, Tye, B.K. | Deposit date: | 2018-04-21 | Release date: | 2018-07-11 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure of the origin recognition complex bound to DNA replication origin. Nature, 559, 2018
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6OM3
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![BU of 6om3 by Molmil](/molmil-images/mine/6om3) | Crystal structure of the Orc1 BAH domain in complex with a nucleosome core particle | Descriptor: | DNA (146-MER), DNA (147-MER), Histone H2A, ... | Authors: | De Ioannes, P.E, Wang, M, Armache, K.-J. | Deposit date: | 2019-04-18 | Release date: | 2019-07-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structure and function of the Orc1 BAH-nucleosome complex. Nat Commun, 10, 2019
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7E9C
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![BU of 7e9c by Molmil](/molmil-images/mine/7e9c) | Cryo-EM structure of the 1:1 Orc1 BAH domain in complex with nucleosome | Descriptor: | DNA (147-mer), Histone H2A.2, Histone H2B.2, ... | Authors: | Jiang, H, Yu, C, Liu, C.P, Han, X, Yu, Z, Xu, R.M. | Deposit date: | 2021-03-04 | Release date: | 2022-09-07 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Nucleosome binding relinquishes the association of the BAH domain of Orc1 with Sir1 To Be Published
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7MCA
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![BU of 7mca by Molmil](/molmil-images/mine/7mca) | |
5V8F
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![BU of 5v8f by Molmil](/molmil-images/mine/5v8f) | Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1 | Descriptor: | Cell division control protein 6, Cell division cycle protein CDT1, DNA (39-MER), ... | Authors: | Yuan, Z, Riera, A, Bai, L, Sun, J, Spanos, C, Chen, Z.A, Barbon, M, Rappsilber, J, Stillman, B, Speck, C, Li, H. | Deposit date: | 2017-03-21 | Release date: | 2017-05-10 | Last modified: | 2020-04-22 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1. Nat. Struct. Mol. Biol., 24, 2017
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7E9F
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![BU of 7e9f by Molmil](/molmil-images/mine/7e9f) | Cryo-EM structure of the 2:1 Orc1 BAH domain in complex with nucleosome | Descriptor: | DNA (147-mer), Histone H2A.2, Histone H2B.2, ... | Authors: | Jiang, H, Yu, C, Liu, C.P, Han, X, Yu, Z, Xu, R.M. | Deposit date: | 2021-03-04 | Release date: | 2022-09-07 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Nucleosome binding relinquishes the association of the BAH domain of Orc1 with Sir1 To Be Published
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6WGC
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![BU of 6wgc by Molmil](/molmil-images/mine/6wgc) | Atomic model of semi-attached mutant OCCM-DNA complex (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) | Descriptor: | Cell division control protein 6, DNA (41-MER), DNA replication licensing factor MCM3, ... | Authors: | Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. | Deposit date: | 2020-04-05 | Release date: | 2020-07-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proc.Natl.Acad.Sci.USA, 117, 2020
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6RQC
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![BU of 6rqc by Molmil](/molmil-images/mine/6rqc) | Cryo-EM structure of an MCM loading intermediate | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (88-MER), ... | Authors: | Miller, T.C.R, Locke, J, Costa, A. | Deposit date: | 2019-05-15 | Release date: | 2019-11-20 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM. Nature, 575, 2019
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6WGG
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![BU of 6wgg by Molmil](/molmil-images/mine/6wgg) | Atomic model of pre-insertion mutant OCCM-DNA complex(ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) | Descriptor: | Cell division control protein 6, Cell division cycle protein CDT1, DNA (41-MER), ... | Authors: | Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. | Deposit date: | 2020-04-05 | Release date: | 2020-07-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (8.1 Å) | Cite: | Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proc.Natl.Acad.Sci.USA, 117, 2020
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6WGI
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![BU of 6wgi by Molmil](/molmil-images/mine/6wgi) | Atomic model of the mutant OCCM (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) loaded on DNA at 10.5 A resolution | Descriptor: | Cell division control protein 6, Cell division cycle protein CDT1, DNA (34-MER), ... | Authors: | Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. | Deposit date: | 2020-04-05 | Release date: | 2020-07-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (10 Å) | Cite: | Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proc.Natl.Acad.Sci.USA, 117, 2020
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