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PDB: 34 results

5W0I
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CREBBP Bromodomain in complex with Cpd8 (1-(3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1-(tetrahydrofuran-3-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one)
Descriptor: 1-{3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-1-[(3S)-oxolan-3-yl]-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}ethan-1-one, CREB-binding protein, DIMETHYL SULFOXIDE, ...
Authors:Murray, J.M.
Deposit date:2017-05-30
Release date:2018-03-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).
J. Med. Chem., 60, 2017
8CNB
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Crystal structure of CREBBP-Y1503C histone acetyltransferase domain in complex with Coenzyme A
Descriptor: COENZYME A, ZINC ION, histone acetyltransferase
Authors:Mechaly, A.E, Zhang, W, Haouz, A, Green, M, Rodrigues-Lima, F.
Deposit date:2023-02-22
Release date:2024-03-06
Method:X-RAY DIFFRACTION (1.986 Å)
Cite:Crystal structure of CREBBP-Y1503C histone acetyltransferase domain in complex with Coenzyme A
To Be Published
4I9O
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Crystal Structure of GACKIX L664C Tethered to 1-10
Descriptor: 1,2-ETHANEDIOL, 1-{4-[4-chloro-3-(trifluoromethyl)phenyl]-4-hydroxypiperidin-1-yl}-3-sulfanylpropan-1-one, CREB-binding protein
Authors:Wang, N, Meagher, J.L, Stuckey, J.A, Mapp, A.K.
Deposit date:2012-12-05
Release date:2013-03-06
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Ordering a dynamic protein via a small-molecule stabilizer.
J.Am.Chem.Soc., 135, 2013
7LVS
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BU of 7lvs by Molmil
The CBP TAZ1 Domain in Complex with a CITED2-HIF-1-Alpha Fusion Peptide
Descriptor: Cbp/p300-interacting transactivator 2,Hypoxia-inducible factor 1-alpha, Histone lysine acetyltransferase CREBBP, ZINC ION
Authors:Appling, F.D, Berlow, R.B, Stanfield, R.L, Dyson, H.J, Wright, P.E.
Deposit date:2021-02-26
Release date:2021-07-28
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:The molecular basis of allostery in a facilitated dissociation process.
Structure, 29, 2021
8CMZ
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BU of 8cmz by Molmil
Crystal structure of CREBBP-R1446C histone acetyltransferase domain in complex with Coenzyme A
Descriptor: COENZYME A, ZINC ION, histone acetyltransferase
Authors:Mechaly, A.E, Zhang, W, Haouz, A, Green, M, Rodrigues-Lima, F.
Deposit date:2023-02-21
Release date:2024-03-06
Method:X-RAY DIFFRACTION (2.252 Å)
Cite:Crystal structure of CREBBP-R1446C histone acetyltransferase domain in complex with Coenzyme A
To Be Published
6DNQ
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BU of 6dnq by Molmil
HBZ77 in complex with KIX and c-Myb
Descriptor: 1,2-ETHANEDIOL, BZIP factor, CREB-binding protein, ...
Authors:Yang, K, Wright, P.E, Stanfield, R.L.
Deposit date:2018-06-07
Release date:2018-09-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for cooperative regulation of KIX-mediated transcription pathways by the HTLV-1 HBZ activation domain.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5U7G
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BU of 5u7g by Molmil
Crystal Structure of the Catalytic Core of CBP
Descriptor: CREB-binding protein, ZINC ION
Authors:Park, S, Stanfield, R.L, Martinez-Yamout, M.M, Dyson, H.J, Wilson, I.A, Wright, P.E.
Deposit date:2016-12-12
Release date:2017-06-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Role of the CBP catalytic core in intramolecular SUMOylation and control of histone H3 acetylation.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
8CN0
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BU of 8cn0 by Molmil
Crystal structure of CREBBP-Y1482N histone acetyltransferase domain in complex with Coenzyme A
Descriptor: COENZYME A, ZINC ION, histone acetyltransferase
Authors:Mechaly, A.E, Zhang, W, Haouz, A, Green, M, Rodrigues-Lima, F.
Deposit date:2023-02-21
Release date:2024-03-06
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Crystal structure of CREBBP-Y1482N histone acetyltransferase domain in complex with Coenzyme A
To Be Published
8CNA
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BU of 8cna by Molmil
Crystal structure of CREBBP-R1446C histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA
Descriptor: ZINC ION, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate, histone acetyltransferase
Authors:Mechaly, A.E, Zhang, W, Haouz, A, Green, M, Rodrigues-Lima, F.
Deposit date:2023-02-22
Release date:2024-03-06
Method:X-RAY DIFFRACTION (2.463 Å)
Cite:Crystal structure of CREBBP-R1446C histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA
To Be Published
8OG2
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Crystal structure of CREBBP histone acetyltransferase domain in complex with Coenzyme A
Descriptor: COENZYME A, SODIUM ION, SULFATE ION, ...
Authors:Mechaly, A.E, Zhang, W, Haouz, A, Green, M, Rodrigues-Lima, F.
Deposit date:2023-03-17
Release date:2024-04-03
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Crystal structure of CREBBP histone acetyltransferase domain in complex with Coenzyme A
To Be Published
6DMX
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HBZ56 in complex with KIX and c-Myb
Descriptor: BZIP factor, CREB-binding protein, Transcriptional activator Myb
Authors:Yang, K, Wright, P.E, Stanfield, R.L.
Deposit date:2018-06-05
Release date:2018-09-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for cooperative regulation of KIX-mediated transcription pathways by the HTLV-1 HBZ activation domain.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8CND
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BU of 8cnd by Molmil
Crystal structure of CREBBP-Y1482N histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA
Descriptor: ZINC ION, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate, histone acetyltransferase
Authors:Mechaly, A.E, Zhang, W, Haouz, A, Green, M, Rodrigues-Lima, F.
Deposit date:2023-02-22
Release date:2024-03-06
Method:X-RAY DIFFRACTION (2.972 Å)
Cite:Crystal structure of CREBBP-Y1482N histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA
To Be Published
1F81
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SOLUTION STRUCTURE OF THE TAZ2 DOMAIN OF THE TRANSCRIPTIONAL ADAPTOR PROTEIN CBP
Descriptor: CREB-BINDING PROTEIN, ZINC ION
Authors:De Guzman, R.N, Liu, H.L, Martinez-Yamout, M, Dyson, H.J, Wright, P.E.
Deposit date:2000-06-28
Release date:2000-10-18
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP.
J.Mol.Biol., 303, 2000
2LQH
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BU of 2lqh by Molmil
NMR structure of FOXO3a transactivation domains (CR2C-CR3) in complex with CBP KIX domain (2b3l conformation)
Descriptor: CREB-binding protein, Forkhead box O3
Authors:Wang, F, Marshall, C.B, Yamamoto, K, Li, G.B, Gasmi-Seabrook, G.M.C, Okada, H, Mak, T.W, Ikura, M.
Deposit date:2012-03-06
Release date:2012-05-16
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment.
Proc.Natl.Acad.Sci.USA, 109, 2012
1U2N
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BU of 1u2n by Molmil
Structure CBP TAZ1 Domain
Descriptor: CREB binding protein, ZINC ION
Authors:De Guzman, R.N, Wojciak, J.M, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E.
Deposit date:2004-07-19
Release date:2005-04-26
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:CBP/p300 TAZ1 domain forms a structured scaffold for ligand binding
Biochemistry, 44, 2005
2LQI
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BU of 2lqi by Molmil
NMR structure of FOXO3a transactivation domains (CR2C-CR3) in complex with CBP KIX domain (2l3b conformation)
Descriptor: CREB-binding protein, Forkhead box O3
Authors:Wang, F, Marshall, C.B, Yamamoto, K, Li, G.B, Gasmi-Seabrook, G.M.C, Okada, H, Mak, T.W, Ikura, M.
Deposit date:2012-03-06
Release date:2012-05-16
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment.
Proc.Natl.Acad.Sci.USA, 109, 2012
1TOT
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BU of 1tot by Molmil
ZZ Domain of CBP- a Novel Fold for a Protein Interaction Module
Descriptor: CREB-binding protein, ZINC ION
Authors:Legge, G.B, Martinez-Yamout, M.A, Hambly, D.M, Trinh, T, Dyson, H.J, Wright, P.E.
Deposit date:2004-06-15
Release date:2005-01-18
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:ZZ domain of CBP: an unusual zinc finger fold in a protein interaction module
J.Mol.Biol., 343, 2004
5U4K
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BU of 5u4k by Molmil
NMR structure of the complex between the KIX domain of CBP and the transactivation domain 1 of p65
Descriptor: CREB-binding protein, Transcription factor p65
Authors:Lecoq, L, Raiola, L, Chabot, P.R, Cyr, N, Arseneault, G, Omichinski, J.G.
Deposit date:2016-12-05
Release date:2017-03-08
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structural characterization of interactions between transactivation domain 1 of the p65 subunit of NF-kappa B and transcription regulatory factors.
Nucleic Acids Res., 45, 2017
2C52
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BU of 2c52 by Molmil
Structural diversity in CBP p160 complexes
Descriptor: CREB-BINDING PROTEIN, NUCLEAR RECEPTOR COACTIVATOR 1
Authors:Waters, L.C, Yue, B, Veverka, V, Renshaw, P.S, Bramham, J, Matsuda, S, Frenkiel, T, Kelly, G, Muskett, F.W, Carr, M.D, Heery, D.M.
Deposit date:2005-10-25
Release date:2006-03-15
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural diversity in p160/CREB-binding protein coactivator complexes.
J. Biol. Chem., 281, 2006
5HPD
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BU of 5hpd by Molmil
Solution Structure of TAZ2-p53TAD
Descriptor: CREB-binding protein,Cellular tumor antigen p53 fusion protein, ZINC ION
Authors:Krois, A.S, Ferreon, J.C, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E.
Deposit date:2016-01-20
Release date:2016-03-16
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein.
Proc.Natl.Acad.Sci.USA, 113, 2016
5HOU
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BU of 5hou by Molmil
Solution Structure of p53TAD-TAZ1
Descriptor: Cellular tumor antigen p53,CREB-binding protein fusion protein, ZINC ION
Authors:Krois, A.S, Ferreon, J.C, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E.
Deposit date:2016-01-19
Release date:2016-03-16
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein.
Proc.Natl.Acad.Sci.USA, 113, 2016
1KBH
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BU of 1kbh by Molmil
Mutual Synergistic Folding in the Interaction Between Nuclear Receptor Coactivators CBP and ACTR
Descriptor: CREB-BINDING PROTEIN, nuclear receptor coactivator
Authors:Demarest, S.J, Martinez-Yamout, M, Chung, J, Chen, H, Xu, W, Dyson, H.J, Evans, R.M, Wright, P.E.
Deposit date:2001-11-06
Release date:2002-02-06
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators.
Nature, 415, 2002
1SB0
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BU of 1sb0 by Molmil
Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb
Descriptor: protein CBP, protein c-Myb
Authors:Zor, T, De Guzman, R.N, Dyson, H.J, Wright, P.E.
Deposit date:2004-02-09
Release date:2004-04-13
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution Structure of the KIX Domain of CBP Bound to the Transactivation Domain of c-Myb
J.Mol.Biol., 337, 2004
1KDX
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KIX DOMAIN OF MOUSE CBP (CREB BINDING PROTEIN) IN COMPLEX WITH PHOSPHORYLATED KINASE INDUCIBLE DOMAIN (PKID) OF RAT CREB (CYCLIC AMP RESPONSE ELEMENT BINDING PROTEIN), NMR 17 STRUCTURES
Descriptor: CBP, CREB
Authors:Radhakrishnan, I, Perez-Alvarado, G.C, Dyson, H.J, Wright, P.E.
Deposit date:1997-09-16
Release date:1998-11-25
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions.
Cell(Cambridge,Mass.), 91, 1997
5HP0
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Solution Structure of TAZ2-p53AD2
Descriptor: CREB-binding protein,Cellular tumor antigen p53 fusion protein, ZINC ION
Authors:Krois, A.S, Ferreon, J.C, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E.
Deposit date:2016-01-19
Release date:2016-03-16
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein.
Proc.Natl.Acad.Sci.USA, 113, 2016

 

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