1F81
SOLUTION STRUCTURE OF THE TAZ2 DOMAIN OF THE TRANSCRIPTIONAL ADAPTOR PROTEIN CBP
Summary for 1F81
| Entry DOI | 10.2210/pdb1f81/pdb |
| Descriptor | CREB-BINDING PROTEIN, ZINC ION (2 entities in total) |
| Functional Keywords | zinc finger, taz2, cbp, transcription |
| Biological source | Mus musculus (house mouse) |
| Cellular location | Cytoplasm (By similarity): P45481 |
| Total number of polymer chains | 1 |
| Total formula weight | 10200.25 |
| Authors | De Guzman, R.N.,Liu, H.L.,Martinez-Yamout, M.,Dyson, H.J.,Wright, P.E. (deposition date: 2000-06-28, release date: 2000-10-18, Last modification date: 2024-05-22) |
| Primary citation | De Guzman, R.N.,Liu, H.Y.,Martinez-Yamout, M.,Dyson, H.J.,Wright, P.E. Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP. J.Mol.Biol., 303:243-253, 2000 Cited by PubMed Abstract: The TAZ2 (CH3) domain of the transcriptional adapter protein CBP has been implicated in direct functional interactions with numerous cellular transcription factors and viral oncoproteins. The solution structure of the TAZ2 domain of murine CBP has been determined by nuclear magnetic resonance (NMR). The protein adopts a novel helical fold stabilized by three zinc ions, each of which is bound to one histidine and three cysteine ligands in HCCC-type motifs. Each zinc-binding site is formed from the carboxy terminus of an alpha-helix, a short loop, and the amino terminus of the next alpha-helix. A peptide derived from the N-terminal transactivation domain of p53 binds specifically to one face of the TAZ2 domain. The close similarities between the TAZ2 and TAZ1 (CH1 domain of CBP/p300) sequences suggest that both domains will adopt similar three-dimensional structures. PubMed: 11023789DOI: 10.1006/jmbi.2000.4141 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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