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PDB: 14 results

2V0H
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BU of 2v0h by Molmil
Characterization of Substrate Binding and Catalysis of the Potential Antibacterial Target N-acetylglucosamine-1-phosphate Uridyltransferase (GlmU)
Descriptor: BIFUNCTIONAL PROTEIN GLMU, COBALT (II) ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Mochalkin, I, Lightle, S, Ohren, J.F, Chirgadze, N.Y.
Deposit date:2007-05-14
Release date:2008-01-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Characterization of Substrate Binding and Catalysis in the Potential Antibacterial Target N-Acetylglucosamine-1-Phosphate Uridyltransferase (Glmu).
Protein Sci., 16, 2007
2V0I
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BU of 2v0i by Molmil
Characterization of Substrate Binding and Catalysis of the Potential Antibacterial Target N-acetylglucosamine-1-phosphate Uridyltransferase (GlmU)
Descriptor: BIFUNCTIONAL PROTEIN GLMU, DI(HYDROXYETHYL)ETHER, SULFATE ION, ...
Authors:Mochalkin, I, Lightle, S, Ohren, J.F, Chirgadze, N.Y.
Deposit date:2007-05-14
Release date:2008-01-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Characterization of Substrate Binding and Catalysis in the Potential Antibacterial Target N-Acetylglucosamine-1-Phosphate Uridyltransferase (Glmu).
Protein Sci., 16, 2007
4KNX
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BU of 4knx by Molmil
Hin GlmU Bound to WG176
Descriptor: Bifunctional protein GlmU, MAGNESIUM ION, SULFATE ION, ...
Authors:Doig, P, Kazmirski, S.L, Boriack-Sjodin, P.A.
Deposit date:2013-05-10
Release date:2014-10-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Rational design of inhibitors of the bacterial cell wall synthetic enzyme GlmU using virtual screening and lead-hopping.
Bioorg.Med.Chem., 22, 2014
2VD4
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BU of 2vd4 by Molmil
Structure of small-molecule inhibitor of Glmu from Haemophilus influenzae reveals an allosteric binding site
Descriptor: 4-chloro-N-(3-methoxypropyl)-N-[(3S)-1-(2-phenylethyl)piperidin-3-yl]benzamide, BIFUNCTIONAL PROTEIN GLMU, MAGNESIUM ION, ...
Authors:Mochalkin, I, Lightle, S, McDowell, L.
Deposit date:2007-09-28
Release date:2008-01-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of a Small-Molecule Inhibitor Complexed with Glmu from Haemophilus Influenzae Reveals an Allosteric Binding Site.
Protein Sci., 17, 2008
2W0V
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BU of 2w0v by Molmil
Crystal structure of Glmu from Haemophilus influenzae in complex with quinazoline inhibitor 1
Descriptor: 6-(CYCLOPROP-2-EN-1-YLMETHOXY)-2-[6-(CYCLOPROPYLMETHYL)-5-OXO-3,4,5,6-TETRAHYDRO-2,6-NAPHTHYRIDIN-2(1H)-YL]-7-METHOXYQUINAZOLIN-4(3H)-ONE, GLUCOSAMINE-1-PHOSPHATE N-ACETYLTRANSFERASE, SULFATE ION, ...
Authors:Mochalkin, I, Melnick, M.
Deposit date:2008-10-10
Release date:2009-11-17
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Discovery and Initial Sar of Quinazoline Inhibitors of Glmu from Haemophilus Influenzae
To be Published
4E1K
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BU of 4e1k by Molmil
GlmU in complex with a Quinazoline Compound
Descriptor: Bifunctional protein GlmU, N-{4-[(7-hydroxy-6-methoxyquinazolin-4-yl)amino]phenyl}benzamide, SULFATE ION, ...
Authors:Larsen, N.A, Doig, P.
Deposit date:2012-03-06
Release date:2013-05-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:An aminoquinazoline inhibitor of the essential bacterial cell wall synthetic enzyme GlmU has a unique non-protein-kinase-like binding mode.
Biochem.J., 446, 2012
2V0J
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BU of 2v0j by Molmil
Characterization of Substrate Binding and Catalysis of the Potential Antibacterial Target N-acetylglucosamine-1-phosphate Uridyltransferase (GlmU)
Descriptor: 5,6-DIHYDROURIDINE-5'-MONOPHOSPHATE, BIFUNCTIONAL PROTEIN GLMU, MAGNESIUM ION, ...
Authors:Mochalkin, I, Lightle, S, Ohren, J.F, Chirgadze, N.Y.
Deposit date:2007-05-14
Release date:2008-01-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Characterization of Substrate Binding and Catalysis in the Potential Antibacterial Target N-Acetylglucosamine-1-Phosphate Uridyltransferase (Glmu).
Protein Sci., 16, 2007
4KPZ
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BU of 4kpz by Molmil
Hin GlmU bound to a small molecule fragment
Descriptor: 1-(3-nitrophenyl)dihydropyrimidine-2,4(1H,3H)-dione, Bifunctional protein GlmU, MAGNESIUM ION, ...
Authors:Doig, P, Kazmirski, S.L, Boriack-Sjodin, P.A.
Deposit date:2013-05-14
Release date:2014-10-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Rational design of inhibitors of the bacterial cell wall synthetic enzyme GlmU using virtual screening and lead-hopping.
Bioorg.Med.Chem., 22, 2014
4KNR
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BU of 4knr by Molmil
Hin GlmU bound to WG188
Descriptor: Bifunctional protein GlmU, MAGNESIUM ION, N-{4-[(2-benzyl-7-hydroxy-6-methoxyquinazolin-4-yl)amino]phenyl}benzamide, ...
Authors:Doig, P, Kazmirski, S.L, Boriack-Sjodin, P.A.
Deposit date:2013-05-10
Release date:2014-10-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Rational design of inhibitors of the bacterial cell wall synthetic enzyme GlmU using virtual screening and lead-hopping.
Bioorg.Med.Chem., 22, 2014
2V0L
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BU of 2v0l by Molmil
Characterization of Substrate Binding and Catalysis of the Potential Antibacterial Target N-acetylglucosamine-1-phosphate Uridyltransferase (GlmU)
Descriptor: BIFUNCTIONAL PROTEIN GLMU, SULFATE ION, TETRAETHYLENE GLYCOL, ...
Authors:Mochalkin, I, Lightle, S, Ohren, J.F, Chirgadze, N.Y.
Deposit date:2007-05-14
Release date:2008-01-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Characterization of Substrate Binding and Catalysis in the Potential Antibacterial Target N-Acetylglucosamine-1-Phosphate Uridyltransferase (Glmu).
Protein Sci., 16, 2007
4KPX
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BU of 4kpx by Molmil
Hin GlmU bound to WG766
Descriptor: Bifunctional protein GlmU, MAGNESIUM ION, N-{4-[(4-hydroxy-3-nitrobenzoyl)amino]phenyl}pyridine-2-carboxamide, ...
Authors:Doig, P, Kazmirski, S.L, Boriack-Sjodin, P.A.
Deposit date:2013-05-14
Release date:2014-10-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Rational design of inhibitors of the bacterial cell wall synthetic enzyme GlmU using virtual screening and lead-hopping.
Bioorg.Med.Chem., 22, 2014
2V0K
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BU of 2v0k by Molmil
Characterization of Substrate Binding and Catalysis of the Potential Antibacterial Target N-acetylglucosamine-1-phosphate Uridyltransferase (GlmU)
Descriptor: BIFUNCTIONAL PROTEIN GLMU, SULFATE ION, TETRAETHYLENE GLYCOL, ...
Authors:Mochalkin, I, Lightle, S, Ohren, J.F, Chirgadze, N.Y.
Deposit date:2007-05-14
Release date:2008-01-15
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Characterization of Substrate Binding and Catalysis in the Potential Antibacterial Target N-Acetylglucosamine-1-Phosphate Uridyltransferase (Glmu).
Protein Sci., 16, 2007
4KQL
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BU of 4kql by Molmil
Hin GlmU bound to WG578
Descriptor: Bifunctional protein GlmU, MAGNESIUM ION, N-(4-{[3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-5-methoxybenzoyl]amino}phenyl)pyridine-2-carboxamide, ...
Authors:Doig, P, Kazmirski, S.L, Boriack-Sjodin, P.A.
Deposit date:2013-05-15
Release date:2014-10-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Rational design of inhibitors of the bacterial cell wall synthetic enzyme GlmU using virtual screening and lead-hopping.
Bioorg.Med.Chem., 22, 2014
2W0W
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BU of 2w0w by Molmil
Crystal structure of Glmu from Haemophilus influenzae in complex with quinazoline inhibitor 2
Descriptor: GLUCOSAMINE-1-PHOSPHATE N-ACETYLTRANSFERASE, N-{6-(CYCLOPROPYLMETHOXY)-7-METHOXY-2-[6-(2-METHYLPROPYL)-5-OXO-3,4,5,6-TETRAHYDRO-2,6-NAPHTHYRIDIN-2(1H)-YL]QUINAZOLIN-4-YL}-2,2,2-TRIFLUOROETHANESULFONAMIDE, TETRAETHYLENE GLYCOL
Authors:Mochalkin, I, Melnick, M.
Deposit date:2008-10-10
Release date:2009-11-17
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Discovery and Initial Sar of Quinazoline Inhibitors of Glmu from Haemophilus Influenzae
To be Published

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