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PDB: 17 results

8AG6
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BU of 8ag6 by Molmil
human MutSalpha (MSH2/MSH6) binding to DNA with a GT mismatch
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (50-MER), DNA mismatch repair protein Msh2, ...
Authors:Bruekner, S.R, Sixma, T.K.
Deposit date:2022-07-19
Release date:2023-01-25
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Unexpected moves: a conformational change in MutS alpha enables high-affinity DNA mismatch binding.
Nucleic Acids Res., 51, 2023
3THW
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BU of 3thw by Molmil
Human MutSbeta complexed with an IDL of 4 bases (Loop4) and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA Loop4 hairpin, DNA mismatch repair protein Msh2, ...
Authors:Yang, W.
Deposit date:2011-08-19
Release date:2011-12-21
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Mechanism of mismatch recognition revealed by human MutSbeta bound to unpaired DNA loops
Nat.Struct.Mol.Biol., 19, 2012
3THY
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BU of 3thy by Molmil
Human MutSbeta complexed with an IDL of 2 bases (Loop2) and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA Loop2 minus strand, DNA Loop2 plus strand, ...
Authors:Yang, W.
Deposit date:2011-08-19
Release date:2011-12-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.894 Å)
Cite:Mechanism of mismatch repair revealed by human MutSbeta bound to unpaired DNA loops
Nat.Struct.Mol.Biol., 19, 2012
3THZ
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BU of 3thz by Molmil
Human MutSbeta complexed with an IDL of 6 bases (Loop6) and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA Loop6 minus strand, DNA Loop6 plus strand, ...
Authors:Yang, W.
Deposit date:2011-08-19
Release date:2011-12-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Mechanism of mismatch repair revealed by human MutS bound to unpaired DNA loops
Nat.Struct.Mol.Biol., 19, 2012
3THX
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BU of 3thx by Molmil
Human MutSbeta complexed with an IDL of 3 bases (Loop3) and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA Loop3 minus strand, DNA Loop3 plus strand, ...
Authors:Yang, W.
Deposit date:2011-08-19
Release date:2011-12-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanism of mismatch recognition revealed by human MutSbeta bound to unpaired DNA loops
Nat.Struct.Mol.Biol., 19, 2012
2O8B
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BU of 2o8b by Molmil
human MutSalpha (MSH2/MSH6) bound to ADP and a G T mispair
Descriptor: 5'-D(*CP*CP*TP*AP*GP*CP*GP*TP*GP*CP*GP*GP*TP*TP*C)-3', 5'-D(*GP*AP*AP*CP*CP*GP*CP*GP*CP*GP*CP*TP*AP*GP*G)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Warren, J.J, Pohlhaus, T.J, Changela, A, Modrich, P.L, Beese, L.S.
Deposit date:2006-12-12
Release date:2007-06-05
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure of the Human MutSalpha DNA Lesion Recognition Complex.
Mol.Cell, 26, 2007
2O8E
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BU of 2o8e by Molmil
human MutSalpha (MSH2/MSH6) bound to a G T mispair, with ADP bound to MSH2 only
Descriptor: 5'-D(*CP*CP*TP*AP*GP*CP*CP*TP*GP*CP*GP*GP*TP*TP*C)-3', 5'-D(*GP*AP*AP*CP*CP*GP*CP*GP*GP*GP*CP*TP*AP*GP*G)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Warren, J.J, Pohlhaus, T.J, Changela, A, Modrich, P.L, Beese, L.S.
Deposit date:2006-12-12
Release date:2007-06-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of the Human MutSalpha DNA Lesion Recognition Complex.
Mol.Cell, 26, 2007
2O8F
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BU of 2o8f by Molmil
human MutSalpha (MSH2/MSH6) bound to DNA with a single base T insert
Descriptor: 5'-D(*CP*GP*CP*TP*AP*GP*CP*GP*TP*GP*CP*GP*GP*CP*CP*GP*TP*C)-3', 5'-D(*GP*AP*CP*GP*GP*CP*CP*GP*CP*CP*GP*CP*TP*AP*GP*CP*G)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Warren, J.J, Pohlhaus, T.J, Changela, A, Modrich, P.L, Beese, L.S.
Deposit date:2006-12-12
Release date:2007-06-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structure of the Human MutSalpha DNA Lesion Recognition Complex.
Mol.Cell, 26, 2007
2O8C
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BU of 2o8c by Molmil
human MutSalpha (MSH2/MSH6) bound to ADP and an O6-methyl-guanine T mispair
Descriptor: 5'-D(*CP*CP*TP*AP*GP*CP*GP*TP*GP*CP*GP*GP*TP*TP*C)-3', 5'-D(*GP*AP*AP*CP*CP*GP*CP*(6OG)P*CP*GP*CP*TP*AP*GP*G)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Warren, J.J, Pohlhaus, T.J, Changela, A, Modrich, P.L, Beese, L.S.
Deposit date:2006-12-12
Release date:2007-06-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.37 Å)
Cite:Structure of the Human MutSalpha DNA Lesion Recognition Complex.
Mol.Cell, 26, 2007
2O8D
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BU of 2o8d by Molmil
human MutSalpha (MSH2/MSH6) bound to ADP and a G dU mispair
Descriptor: 5'-D(*CP*CP*TP*AP*GP*CP*GP*(DU)P*GP*CP*GP*GP*TP*TP*C)-3', 5'-D(*GP*AP*AP*CP*CP*GP*CP*GP*CP*GP*CP*TP*AP*GP*G)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Warren, J.J, Pohlhaus, T.J, Changela, A, Modrich, P.L, Beese, L.S.
Deposit date:2006-12-12
Release date:2007-06-05
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the Human MutSalpha DNA Lesion Recognition Complex.
Mol.Cell, 26, 2007
8OM9
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BU of 8om9 by Molmil
MutSbeta bound to (CAG)2 DNA (open form)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA mismatch repair protein Msh2, DNA mismatch repair protein Msh3, ...
Authors:Lee, J.-H, Thomsen, M, Daub, H, Steinbacher, S, Sztyler, A, Thieulin-Pardo, G, Neudegger, T, Plotnikov, N, Iyer, R.R, Wilkinson, H, Monteagudo, E, Felsenfeld, D.P, Haque, T, Finley, M, Dominguez, C, Vogt, T.F, Prasad, B.C.
Deposit date:2023-03-31
Release date:2023-05-24
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:MutSbeta bound to (CAG)2 DNA (open form)
To Be Published
8OLX
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BU of 8olx by Molmil
MutSbeta bound to (CAG)2 DNA (canonical form)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (25-MER), DNA mismatch repair protein Msh2, ...
Authors:Lee, J.-H, Thomsen, M, Daub, H, Steinbacher, S, Sztyler, A, Thieulin-Pardo, G, Neudegger, T, Plotnikov, N, Iyer, R.R, Wilkinson, H, Monteagudo, E, Felsenfeld, D.P, Haque, T, Finley, M, Dominguez, C, Vogt, T.F, Prasad, B.C.
Deposit date:2023-03-30
Release date:2023-05-24
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:MutSbeta bound to (CAG)2 DNA (canonical form)
To Be Published
8OMO
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BU of 8omo by Molmil
DNA-unbound MutSbeta-ATP complex (bent clamp form)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA mismatch repair protein Msh2, DNA mismatch repair protein Msh3, ...
Authors:Lee, J.-H, Thomsen, M, Daub, H, Steinbacher, S, Sztyler, A, Thieulin-Pardo, G, Neudegger, T, Plotnikov, N, Iyer, R.R, Wilkinson, H, Monteagudo, E, Felsenfeld, D.P, Haque, T, Finley, M, Dominguez, C, Vogt, T.F, Prasad, B.C.
Deposit date:2023-03-31
Release date:2023-05-24
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:DNA-unbound MutSbeta-ATP complex (bent clamp form)
To Be Published
8OM5
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BU of 8om5 by Molmil
DNA-free open form of MutSbeta
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA mismatch repair protein Msh2, DNA mismatch repair protein Msh3, ...
Authors:Lee, J.-H, Thomsen, M, Daub, H, Steinbacher, S, Sztyler, A, Thieulin-Pardo, G, Neudegger, T, Plotnikov, N, Iyer, R.R, Wilkinson, H, Monteagudo, E, Felsenfeld, D.P, Haque, T, Finley, M, Dominguez, C, Vogt, T.F, Prasad, B.C.
Deposit date:2023-03-31
Release date:2023-05-24
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:DNA-free open form of MutSbeta
To Be Published
8OMA
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BU of 8oma by Molmil
MutSbeta bound to 61bp homoduplex DNA
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA mismatch repair protein Msh2, DNA mismatch repair protein Msh3, ...
Authors:Lee, J.-H, Thomsen, M, Daub, H, Steinbacher, S, Sztyler, A, Thieulin-Pardo, G, Neudegger, T, Plotnikov, N, Iyer, R.R, Wilkinson, H, Monteagudo, E, Felsenfeld, D.P, Haque, T, Finley, M, Dominguez, C, Vogt, T.F, Prasad, B.C.
Deposit date:2023-03-31
Release date:2023-05-24
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.29 Å)
Cite:MutSbeta bound to 61bp homoduplex DNA
To Be Published
8OMQ
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BU of 8omq by Molmil
DNA-unbound MutSbeta-ATP complex (straight clamp form)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA mismatch repair protein Msh2, DNA mismatch repair protein Msh3, ...
Authors:Lee, J.-H, Thomsen, M, Daub, H, Steinbacher, S, Sztyler, A, Thieulin-Pardo, G, Neudegger, T, Plotnikov, N, Iyer, R.R, Wilkinson, H, Monteagudo, E, Felsenfeld, D.P, Haque, T, Finley, M, Dominguez, C, Vogt, T.F, Prasad, B.C.
Deposit date:2023-03-31
Release date:2023-05-24
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.11 Å)
Cite:DNA-unbound MutSbeta-ATP complex (straight clamp form)
To Be Published
8R7V
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BU of 8r7v by Molmil
MutSbeta bound to compound CHDI-00898647 in the canonical DNA-mismatch bound form
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA mismatch repair protein Msh2, DNA mismatch repair protein Msh3, ...
Authors:Haque, T, Brace, G, Felsenfeld, D, Tilack, K, Schaertl, S, Ballantyne, G, Maillard, M, Iyer, R, Prasad, B, Thomsen, M, Wilkionson, H, Plotnikov, N, Ritzefeld, M.
Deposit date:2023-11-27
Release date:2024-10-30
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:Identification of orthosteric inhibitors of MutSbeta ATPase function
To Be Published

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