2O8B

human MutSalpha (MSH2/MSH6) bound to ADP and a G T mispair

Summary for 2O8B

• Entry DOI: 10.2210/pdb2o8b/pdb
• Related: 2O8C 2O8D 2O8E 2O8F
• Descriptor: 5'-D(*GP*AP*AP*CP*CP*GP*CP*GP*CP*GP*CP*TP*AP*GP*G)-3', 5'-D(*CP*CP*TP*AP*GP*CP*GP*TP*GP*CP*GP*GP*TP*TP*C)-3', DNA mismatch repair protein Msh2, ... (7 entities in total)
• Functional Keywords: dna mismatch repair, dna damage response, somatic hypermutation, protein-dna complex, dna mispair, cancer, abc transporter atpase, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus (Potential): P43246; Nucleus: P52701
• Total number of polymer chains: 4
• Total formula weight: 231018.52

Authors

Warren, J.J.,Pohlhaus, T.J.,Changela, A.,Modrich, P.L.,Beese, L.S. (deposition date: 2006-12-12, release date: 2007-06-05, Last modification date: 2023-12-27)

• Primary citation: Warren, J.J.,Pohlhaus, T.J.,Changela, A.,Iyer, R.R.,Modrich, P.L.,Beese, L.S.; Structure of the Human MutSalpha DNA Lesion Recognition Complex.; Mol.Cell, 26:579-592, 2007; PubMed: 17531815; DOI: 10.1016/j.molcel.2007.04.018

Experimental method

X-RAY DIFFRACTION (2.75 Å)