2O8B

human MutSalpha (MSH2/MSH6) bound to ADP and a G T mispair

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0000400	molecular_function	four-way junction DNA binding
A	0000781	cellular_component	chromosome, telomeric region
A	0001701	biological_process	in utero embryonic development
A	0002204	biological_process	somatic recombination of immunoglobulin genes involved in immune response
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003684	molecular_function	damaged DNA binding
A	0003690	molecular_function	double-stranded DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0006119	biological_process	oxidative phosphorylation
A	0006281	biological_process	DNA repair
A	0006298	biological_process	mismatch repair
A	0006301	biological_process	DNA damage tolerance
A	0006302	biological_process	double-strand break repair
A	0006312	biological_process	mitotic recombination
A	0006974	biological_process	DNA damage response
A	0007281	biological_process	germ cell development
A	0008047	molecular_function	enzyme activator activity
A	0008094	molecular_function	ATP-dependent activity, acting on DNA
A	0008340	biological_process	determination of adult lifespan
A	0008584	biological_process	male gonad development
A	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
A	0010165	biological_process	response to X-ray
A	0010224	biological_process	response to UV-B
A	0016020	cellular_component	membrane
A	0016446	biological_process	somatic hypermutation of immunoglobulin genes
A	0016447	biological_process	somatic recombination of immunoglobulin gene segments
A	0016887	molecular_function	ATP hydrolysis activity
A	0019237	molecular_function	centromeric DNA binding
A	0019724	biological_process	B cell mediated immunity
A	0030183	biological_process	B cell differentiation
A	0030983	molecular_function	mismatched DNA binding
A	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
A	0032137	molecular_function	guanine/thymine mispair binding
A	0032139	molecular_function	dinucleotide insertion or deletion binding
A	0032142	molecular_function	single guanine insertion binding
A	0032143	molecular_function	single thymine insertion binding
A	0032181	molecular_function	dinucleotide repeat insertion binding
A	0032301	cellular_component	MutSalpha complex
A	0032302	cellular_component	MutSbeta complex
A	0032357	molecular_function	oxidized purine DNA binding
A	0032405	molecular_function	MutLalpha complex binding
A	0042771	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
A	0042803	molecular_function	protein homodimerization activity
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0043531	molecular_function	ADP binding
A	0043570	biological_process	maintenance of DNA repeat elements
A	0045190	biological_process	isotype switching
A	0045910	biological_process	negative regulation of DNA recombination
A	0048298	biological_process	positive regulation of isotype switching to IgA isotypes
A	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
A	0051726	biological_process	regulation of cell cycle
A	0140664	molecular_function	ATP-dependent DNA damage sensor activity
B	0005524	molecular_function	ATP binding
B	0006298	biological_process	mismatch repair
B	0030983	molecular_function	mismatched DNA binding
B	0140664	molecular_function	ATP-dependent DNA damage sensor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 935

Chain	Residue
A	SER676
A	ADP936

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG B 102

Chain	Residue
B	ADP202
B	SER1141

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP A 936

Chain	Residue
A	MET672
A	GLY673
A	GLY674
A	LYS675
A	SER676
A	THR677
A	TYR815
A	MG935
A	ILE648
A	ALA649
A	PHE650
A	ILE651
A	ASN671

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP B 202

Chain	Residue
B	MG102
B	PHE1108
B	ILE1109
B	PRO1135
B	ASN1136
B	MET1137
B	GLY1138
B	GLY1139
B	LYS1140
B	SER1141
B	THR1142
B	TYR1287

---

Functional Information from PROSITE/UniProt

site_id	PS00486
Number of Residues	17
Details	DNA_MISMATCH_REPAIR_2 DNA mismatch repair proteins mutS family signature. SLiIiDELGRGTstydG

Chain	Residue	Details
A	SER743-GLY759
B	SER1208-GLY1224

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	70
Details	Region: {"description":"Interaction with EXO1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P43247","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"24882211","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"24882211","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---