1WMH
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![BU of 1wmh by Molmil](/molmil-images/mine/1wmh) | Crystal structure of a PB1 domain complex of Protein kinase c iota and Par6 alpha | Descriptor: | Partitioning defective-6 homolog alpha, Protein kinase C, iota type | Authors: | Hirano, Y, Yoshinaga, S, Suzuki, N.N, Horiuchi, M, Kohjima, M, Takeya, R, Sumimoto, H, Inagaki, F. | Deposit date: | 2004-07-09 | Release date: | 2004-12-07 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure of a Cell Polarity Regulator, a Complex between Atypical PKC and Par6 PB1 Domains J.Biol.Chem., 280, 2005
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5LI9
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![BU of 5li9 by Molmil](/molmil-images/mine/5li9) | Structure of a nucleotide-bound form of PKCiota core kinase domain | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Ivanova, M.E, Purkiss, A.G, McDonald, N.Q. | Deposit date: | 2016-07-14 | Release date: | 2016-09-14 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | aPKC Inhibition by Par3 CR3 Flanking Regions Controls Substrate Access and Underpins Apical-Junctional Polarization. Dev.Cell, 38, 2016
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5LI1
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![BU of 5li1 by Molmil](/molmil-images/mine/5li1) | Structure of a Par3-inhibitory peptide bound to PKCiota core kinase domain | Descriptor: | GLYCEROL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Soriano, E.V, Purkiss, A.G, McDonald, N.Q. | Deposit date: | 2016-07-13 | Release date: | 2016-09-14 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | aPKC Inhibition by Par3 CR3 Flanking Regions Controls Substrate Access and Underpins Apical-Junctional Polarization. Dev.Cell, 38, 2016
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3A8X
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![BU of 3a8x by Molmil](/molmil-images/mine/3a8x) | Crystal Structure of PKCiota kinase domain | Descriptor: | Protein kinase C iota type, SULFATE ION | Authors: | Takimura, T, Kamata, K. | Deposit date: | 2009-10-11 | Release date: | 2010-05-05 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of the PKC-iota kinase domain in its ATP-bound and apo forms reveal defined structures of residues 533-551 in the C-terminal tail and their roles in ATP binding Acta Crystallogr.,Sect.D, 66, 2010
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3A8W
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![BU of 3a8w by Molmil](/molmil-images/mine/3a8w) | Crystal Structure of PKCiota kinase domain | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Protein kinase C iota type, SULFATE ION | Authors: | Takimura, T, Kamata, K. | Deposit date: | 2009-10-11 | Release date: | 2010-05-05 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of the PKC-iota kinase domain in its ATP-bound and apo forms reveal defined structures of residues 533-551 in the C-terminal tail and their roles in ATP binding Acta Crystallogr.,Sect.D, 66, 2010
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3ZH8
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![BU of 3zh8 by Molmil](/molmil-images/mine/3zh8) | A novel small molecule aPKC inhibitor | Descriptor: | (2S)-3-phenyl-N~1~-[2-(pyridin-4-yl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl]propane-1,2-diamine, 1,2-ETHANEDIOL, CHLORIDE ION, ... | Authors: | Kjaer, S, Purkiss, A.G, Kostelecky, B, Knowles, P.P, Soriano, E, Murray-Rust, J, McDonald, N.Q. | Deposit date: | 2012-12-20 | Release date: | 2013-02-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.739 Å) | Cite: | Adenosine-Binding Motif Mimicry and Cellular Effects of a Thieno[2,3-D]Pyrimidine-Based Chemical Inhibitor of Atypical Protein Kinase C Isozymes. Biochem.J., 451, 2013
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1ZRZ
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![BU of 1zrz by Molmil](/molmil-images/mine/1zrz) | Crystal Structure of the Catalytic Domain of Atypical Protein Kinase C-iota | Descriptor: | 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, Protein kinase C, iota | Authors: | Messerschmidt, A, Macieira, S, Velarde, M, Baedeker, M, Benda, C, Jestel, A, Brandstetter, H, Neuefeind, T, Blaesse, M, Structural Proteomics in Europe (SPINE) | Deposit date: | 2005-05-23 | Release date: | 2005-09-13 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal Structure of the Catalytic Domain of Human Atypical Protein Kinase C-iota Reveals Interaction Mode of Phosphorylation Site in Turn Motif J.Mol.Biol., 352, 2005
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5LIH
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![BU of 5lih by Molmil](/molmil-images/mine/5lih) | Structure of a peptide-substrate bound to PKCiota core kinase domain | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MANGANESE (II) ION, ... | Authors: | Soriano, E.V, Purkiss, A.G, McDonald, N.Q. | Deposit date: | 2016-07-14 | Release date: | 2016-09-14 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | aPKC Inhibition by Par3 CR3 Flanking Regions Controls Substrate Access and Underpins Apical-Junctional Polarization. Dev.Cell, 38, 2016
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6ILZ
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![BU of 6ilz by Molmil](/molmil-images/mine/6ilz) | Crystal structure of PKCiota in complex with inhibitor | Descriptor: | 2-amino-5-[3-(piperazin-1-yl)phenyl]-N-(pyridin-4-yl)pyridine-3-carboxamide, Protein kinase C iota type | Authors: | Baburajendran, N, Hill, J. | Deposit date: | 2018-10-21 | Release date: | 2019-06-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.261 Å) | Cite: | Fragment-based Discovery of a Small-Molecule Protein Kinase C-iota Inhibitor Binding Post-kinase Domain Residues. Acs Med.Chem.Lett., 10, 2019
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1VD2
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![BU of 1vd2 by Molmil](/molmil-images/mine/1vd2) | Solution Structure of the PB1 domain of PKCiota | Descriptor: | Protein kinase C, iota type | Authors: | Hirano, Y, Yoshinaga, S, Yokochi, M, Ogura, K, Noda, Y, Sumimoto, H, Inagaki, F. | Deposit date: | 2004-03-18 | Release date: | 2004-09-14 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Solution structure of atypical protein kinase C PB1 domain and its mode of interaction with ZIP/p62 and MEK5 J.Biol.Chem., 279, 2004
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