4U53
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![BU of 4u53 by Molmil](/molmil-images/mine/4u53) | Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome | Descriptor: | (3beta,7alpha)-3,7,15-trihydroxy-12,13-epoxytrichothec-9-en-8-one, 18S ribosomal RNA, 25S ribosomal RNA, ... | Authors: | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | Deposit date: | 2014-07-24 | Release date: | 2014-10-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural basis for the inhibition of the eukaryotic ribosome. Nature, 513, 2014
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7WTL
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![BU of 7wtl by Molmil](/molmil-images/mine/7wtl) | Cryo-EM structure of a yeast pre-40S ribosomal subunit - State Dis-D | Descriptor: | 18S rRNA, 40S ribosomal protein S1-A, 40S ribosomal protein S11-A, ... | Authors: | Cheng, J, La Venuta, G, Lau, B, Berninghausen, O, Beckmann, R, Hurt, E. | Deposit date: | 2022-02-05 | Release date: | 2022-10-19 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | In vitro structural maturation of an early stage pre-40S particle coupled with U3 snoRNA release and central pseudoknot formation. Nucleic Acids Res., 50, 2022
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6SV4
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![BU of 6sv4 by Molmil](/molmil-images/mine/6sv4) | The cryo-EM structure of SDD1-stalled collided trisome. | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | Authors: | Tesina, P, Buschauer, R, Cheng, J, Becker, T, Beckmann, R. | Deposit date: | 2019-09-17 | Release date: | 2020-03-04 | Last modified: | 2020-04-22 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1. Nat.Struct.Mol.Biol., 27, 2020
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6Z6J
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![BU of 6z6j by Molmil](/molmil-images/mine/6z6j) | Cryo-EM structure of yeast Lso2 bound to 80S ribosomes under native condition | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | Authors: | Wells, J.N, Buschauer, R, Mackens-Kiani, T, Best, K, Kratzat, H, Berninghausen, O, Becker, T, Cheng, J, Beckmann, R. | Deposit date: | 2020-05-28 | Release date: | 2020-07-29 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes. Plos Biol., 18, 2020
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6Z6K
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![BU of 6z6k by Molmil](/molmil-images/mine/6z6k) | Cryo-EM structure of yeast reconstituted Lso2 bound to 80S ribosomes | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | Authors: | Wells, J.N, Buschauer, R, Mackens-Kiani, T, Best, K, Kratzat, H, Berninghausen, O, Becker, T, Cheng, J, Beckmann, R. | Deposit date: | 2020-05-28 | Release date: | 2020-07-29 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes. Plos Biol., 18, 2020
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6KE6
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![BU of 6ke6 by Molmil](/molmil-images/mine/6ke6) | |
5OBM
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![BU of 5obm by Molmil](/molmil-images/mine/5obm) | Crystal structure of Gentamicin bound to the yeast 80S ribosome | Descriptor: | (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, 18S ribosomal RNA, 25S ribosomal RNA, ... | Authors: | Prokhorova, I, Djumagulov, M, Urzhumtsev, A, Yusupov, M, Yusupova, G. | Deposit date: | 2017-06-28 | Release date: | 2017-12-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Aminoglycoside interactions and impacts on the eukaryotic ribosome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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7WTN
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![BU of 7wtn by Molmil](/molmil-images/mine/7wtn) | Cryo-EM structure of a yeast pre-40S ribosomal subunit - State Tsr1-1 (with Rps2) | Descriptor: | 18S rRNA, 18S rRNA (guanine(1575)-N(7))-methyltransferase, 40S ribosomal protein S1-A, ... | Authors: | Cheng, J, Lau, B, Thoms, M, Ameismeier, M, Berninghausen, O, Hurt, E, Beckmann, R. | Deposit date: | 2022-02-05 | Release date: | 2022-10-19 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | The nucleoplasmic phase of pre-40S formation prior to nuclear export. Nucleic Acids Res., 50, 2022
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5FCI
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![BU of 5fci by Molmil](/molmil-images/mine/5fci) | Structure of the vacant uL3 W255C mutant 80S yeast ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Mailliot, J, Garreau de Loubresse, N, Yusupova, G, Dinman, J.D, Yusupov, M. | Deposit date: | 2015-12-15 | Release date: | 2016-05-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Crystal Structures of the uL3 Mutant Ribosome: Illustration of the Importance of Ribosomal Proteins for Translation Efficiency. J.Mol.Biol., 428, 2016
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6FAI
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![BU of 6fai by Molmil](/molmil-images/mine/6fai) | Structure of a eukaryotic cytoplasmic pre-40S ribosomal subunit | Descriptor: | 20S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... | Authors: | Scaiola, A, Pena, C, Weisser, M, Boehringer, D, Leibundgut, M, Klingauf-Nerurkar, P, Gerhardy, S, Panse, V.G, Ban, N. | Deposit date: | 2017-12-15 | Release date: | 2018-02-28 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of a eukaryotic cytoplasmic pre-40S ribosomal subunit. EMBO J., 37, 2018
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5DGE
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![BU of 5dge by Molmil](/molmil-images/mine/5dge) | Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Melnikov, S, Mailliot, J, Shin, B.-S, Rigger, L, Yusupova, G, Micura, R, Dever, T.E, Yusupov, M. | Deposit date: | 2015-08-27 | Release date: | 2017-01-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome To Be Published
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4U56
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![BU of 4u56 by Molmil](/molmil-images/mine/4u56) | Crystal structure of Blasticidin S bound to the yeast 80S ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | Deposit date: | 2014-07-24 | Release date: | 2014-10-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Structural basis for the inhibition of the eukaryotic ribosome. Nature, 513, 2014
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6RBD
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![BU of 6rbd by Molmil](/molmil-images/mine/6rbd) | State 1 of yeast Tsr1-TAP Rps20-Deltaloop pre-40S particles | Descriptor: | 20S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... | Authors: | Shayan, R, Mitterer, V, Ferreira-Cerca, S, Murat, G, Enne, T, Rinaldi, D, Weigl, S, Omanic, H, Gleizes, P.E, Kressler, D, Pertschy, B, Plisson-Chastang, C. | Deposit date: | 2019-04-10 | Release date: | 2019-06-26 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Conformational proofreading of distant 40S ribosomal subunit maturation events by a long-range communication mechanism. Nat Commun, 10, 2019
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7ZPQ
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![BU of 7zpq by Molmil](/molmil-images/mine/7zpq) | Structure of the RQT-bound 80S ribosome from S. cerevisiae (C1) | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Best, K.M, Ikeuchi, K, Kater, L, Best, D.M, Musial, J, Matsuo, Y, Berninghausen, O, Becker, T, Inada, T, Beckmann, R. | Deposit date: | 2022-04-28 | Release date: | 2023-02-22 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Structural basis for clearing of ribosome collisions by the RQT complex. Nat Commun, 14, 2023
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5MEI
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![BU of 5mei by Molmil](/molmil-images/mine/5mei) | Crystal structure of Agelastatin A bound to the 80S ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | McClary, B, Zinshteyn, B, Meyer, M, Jouanneau, M, Pellegrino, S, Yusupova, G, Schuller, A, Reyes, J.C.P, Lu, J, Luo, C, Dang, Y, Romo, D, Yusupov, M, Green, R, Liu, J.O. | Deposit date: | 2016-11-15 | Release date: | 2017-06-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A. Cell Chem Biol, 24, 2017
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7WTO
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![BU of 7wto by Molmil](/molmil-images/mine/7wto) | Cryo-EM structure of a yeast pre-40S ribosomal subunit - State Tsr1-1 (without Rps2) | Descriptor: | 18S rRNA, 40S ribosomal protein S1-A, 40S ribosomal protein S11-A, ... | Authors: | Cheng, J, Lau, B, Thoms, M, Ameismeier, M, Berninghausen, O, Hurt, E, Beckmann, R. | Deposit date: | 2022-02-05 | Release date: | 2022-10-19 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | The nucleoplasmic phase of pre-40S formation prior to nuclear export. Nucleic Acids Res., 50, 2022
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7WTM
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![BU of 7wtm by Molmil](/molmil-images/mine/7wtm) | Cryo-EM structure of a yeast pre-40S ribosomal subunit - State Dis-E | Descriptor: | 18S rRNA, 40S ribosomal protein S1-A, 40S ribosomal protein S11-A, ... | Authors: | Cheng, J, La Venuta, G, Lau, B, Berninghausen, O, Beckmann, R, Hurt, E. | Deposit date: | 2022-02-05 | Release date: | 2022-10-19 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | In vitro structural maturation of an early stage pre-40S particle coupled with U3 snoRNA release and central pseudoknot formation. Nucleic Acids Res., 50, 2022
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5TGM
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![BU of 5tgm by Molmil](/molmil-images/mine/5tgm) | Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 3'-amino-3'-deoxyadenosine 5'-(dihydrogen phosphate), ... | Authors: | Melnikov, S, Mailliot, J, Yusupov, M. | Deposit date: | 2016-09-28 | Release date: | 2017-01-18 | Last modified: | 2022-12-07 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Molecular insights into protein synthesis with proline residues. EMBO Rep., 17, 2016
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6ZQG
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![BU of 6zqg by Molmil](/molmil-images/mine/6zqg) | Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Dis-C | Descriptor: | 18S rRNA, 40S ribosomal protein S1-A, 40S ribosomal protein S11-A, ... | Authors: | Cheng, J, Lau, B, Venuta, G.L, Berninghausen, O, Hurt, E, Beckmann, R. | Deposit date: | 2020-07-09 | Release date: | 2020-09-23 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | 90 S pre-ribosome transformation into the primordial 40 S subunit. Science, 369, 2020
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5JUP
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![BU of 5jup by Molmil](/molmil-images/mine/5jup) | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure II (mid-rotated 40S subunit) | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 5.8S ribosomal RNA, ... | Authors: | Abeyrathne, P, Koh, C.S, Grant, T, Grigorieff, N, Korostelev, A.A. | Deposit date: | 2016-05-10 | Release date: | 2016-10-05 | Last modified: | 2019-11-27 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome. Elife, 5, 2016
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7WTR
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![BU of 7wtr by Molmil](/molmil-images/mine/7wtr) | Cryo-EM structure of a yeast pre-40S ribosomal subunit - State Tsr1-3 | Descriptor: | 18S rRNA, 18S rRNA (guanine(1575)-N(7))-methyltransferase, 40S ribosomal protein S1-A, ... | Authors: | Cheng, J, Lau, B, Thoms, M, Ameismeier, M, Berninghausen, O, Hurt, E, Beckmann, R. | Deposit date: | 2022-02-05 | Release date: | 2022-10-19 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | The nucleoplasmic phase of pre-40S formation prior to nuclear export. Nucleic Acids Res., 50, 2022
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8Y0U
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![BU of 8y0u by Molmil](/molmil-images/mine/8y0u) | dormant ribosome with STM1 | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S1-A, ... | Authors: | Du, M, Zeng, F. | Deposit date: | 2024-01-23 | Release date: | 2024-02-07 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Implication of Stm1 in the protection of eIF5A, eEF2 and tRNA through dormant ribosomes. Front Mol Biosci, 11, 2024
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6EML
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![BU of 6eml by Molmil](/molmil-images/mine/6eml) | Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae | Descriptor: | 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, 40S ribosomal protein S11-A, ... | Authors: | Heuer, A, Thomson, E, Schmidt, C, Berninghausen, O, Becker, T, Hurt, E, Beckmann, R. | Deposit date: | 2017-10-02 | Release date: | 2017-11-29 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structure of a late pre-40S ribosomal subunit fromSaccharomyces cerevisiae. Elife, 6, 2017
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4U4O
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![BU of 4u4o by Molmil](/molmil-images/mine/4u4o) | Crystal structure of Geneticin bound to the yeast 80S ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | Deposit date: | 2014-07-24 | Release date: | 2014-10-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structural basis for the inhibition of the eukaryotic ribosome. Nature, 513, 2014
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5NDW
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![BU of 5ndw by Molmil](/molmil-images/mine/5ndw) | Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Prokhorova, I, Djumagulov, M, Urzhumtsev, A, Yusupov, M, Yusupova, G. | Deposit date: | 2017-03-09 | Release date: | 2017-12-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Aminoglycoside interactions and impacts on the eukaryotic ribosome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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