3DFR
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![BU of 3dfr by Molmil](/molmil-images/mine/3dfr) | CRYSTAL STRUCTURES OF ESCHERICHIA COLI AND LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE REFINED AT 1.7 ANGSTROMS RESOLUTION. I. GENERAL FEATURES AND BINDING OF METHOTREXATE | Descriptor: | DIHYDROFOLATE REDUCTASE, METHOTREXATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Filman, D.J, Matthews, D.A, Bolin, J.T, Kraut, J. | Deposit date: | 1982-06-25 | Release date: | 1982-10-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate. J.Biol.Chem., 257, 1982
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2HM9
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![BU of 2hm9 by Molmil](/molmil-images/mine/2hm9) | Solution structure of dihydrofolate reductase complexed with trimethoprim, 33 structures | Descriptor: | 2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM, Dihydrofolate reductase | Authors: | Polshakov, V.I, Birdsall, B. | Deposit date: | 2006-07-11 | Release date: | 2007-06-05 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | NMR structures of apo L.casei dihydrofolate reductase and its complexes with trimethoprim and NADPH. Contributions to positive cooperative binding from ligand-induced refolding, conformational changes and interligand hydrophobic interactions Biochemistry, 2011
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1AO8
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![BU of 1ao8 by Molmil](/molmil-images/mine/1ao8) | DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE, NMR, 21 STRUCTURES | Descriptor: | DIHYDROFOLATE REDUCTASE, METHOTREXATE | Authors: | Gargaro, A.R, Soteriou, A, Frenkiel, T.A, Bauer, C.J, Birdsall, B, Polshakov, V.I, Barsukov, I.L, Roberts, G.C.K, Feeney, J. | Deposit date: | 1997-07-22 | Release date: | 1998-02-25 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The solution structure of the complex of Lactobacillus casei dihydrofolate reductase with methotrexate. J.Mol.Biol., 277, 1998
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1BZF
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![BU of 1bzf by Molmil](/molmil-images/mine/1bzf) | NMR SOLUTION STRUCTURE AND DYNAMICS OF THE COMPLEX OF LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE WITH THE NEW LIPOPHILIC ANTIFOLATE DRUG TRIMETREXATE, 22 STRUCTURES | Descriptor: | DIHYDROFOLATE REDUCTASE, TRIMETREXATE | Authors: | Polshakov, V.I, Birdsall, B, Frenkiel, T.A, Gargaro, A.R, Feeney, J. | Deposit date: | 1998-10-28 | Release date: | 1999-05-18 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure and dynamics in solution of the complex of Lactobacillus casei dihydrofolate reductase with the new lipophilic antifolate drug trimetrexate. Protein Sci., 8, 1999
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1LUD
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![BU of 1lud by Molmil](/molmil-images/mine/1lud) | SOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETHOPRIM AND NADPH, 24 STRUCTURES | Descriptor: | 2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM, DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Polshakov, V.I, Smirnov, E.G, Birdsall, B, Kelly, G, Feeney, J. | Deposit date: | 2002-05-22 | Release date: | 2002-12-18 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | NMR-based solution structure of the complex of Lactobacillus casei dihydrofolate reductase with trimethoprim and NADPH J.Biomol.Nmr, 24, 2002
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1DIS
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![BU of 1dis by Molmil](/molmil-images/mine/1dis) | DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEX WITH BRODIMOPRIM-4,6-DICARBOXYLATE | Descriptor: | BRODIMOPRIM-4,6-DICARBOXYLATE, DIHYDROFOLATE REDUCTASE | Authors: | Morgan, W.D, Birdsall, B, Polshakov, V.I, Sali, D, Kompis, I, Feeney, J. | Deposit date: | 1995-08-01 | Release date: | 1995-11-14 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of a brodimoprim analogue in its complex with Lactobacillus casei dihydrofolate reductase. Biochemistry, 34, 1995
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2L28
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![BU of 2l28 by Molmil](/molmil-images/mine/2l28) | Solution structure of lactobacillus casei dihydrofolate reductase apo-form, 25 conformers | Descriptor: | Dihydrofolate reductase | Authors: | Polshakov, V.I, Birdsall, B, Feeney, J. | Deposit date: | 2010-08-13 | Release date: | 2011-04-06 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | NMR Structures of Apo L. casei Dihydrofolate Reductase and Its Complexes with Trimethoprim and NADPH: Contributions to Positive Cooperative Binding from Ligand-Induced Refolding, Conformational Changes, and Interligand Hydrophobic Interactions. Biochemistry, 50, 2011
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2HQP
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![BU of 2hqp by Molmil](/molmil-images/mine/2hqp) | |
1DIU
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![BU of 1diu by Molmil](/molmil-images/mine/1diu) | DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEX WITH BRODIMOPRIM-4,6-DICARBOXYLATE | Descriptor: | BRODIMOPRIM-4,6-DICARBOXYLATE, DIHYDROFOLATE REDUCTASE | Authors: | Morgan, W.D, Birdsall, B, Polshakov, V.I, Sali, D, Kompis, I, Feeney, J. | Deposit date: | 1995-08-01 | Release date: | 1995-11-14 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of a brodimoprim analogue in its complex with Lactobacillus casei dihydrofolate reductase. Biochemistry, 34, 1995
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2LF1
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![BU of 2lf1 by Molmil](/molmil-images/mine/2lf1) | Solution structure of L. casei dihydrofolate reductase complexed with NADPH, 30 structures | Descriptor: | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Polshakov, V, Feeney, J, Birdsall, B, Kovalevskaya, N. | Deposit date: | 2011-06-28 | Release date: | 2011-12-21 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | NMR structures of apo L. casei dihydrofolate reductase and its complexes with trimethoprim and NADPH: contributions to positive cooperative binding from ligand-induced refolding, conformational changes, and interligand hydrophobic interactions Biochemistry, 50, 2011
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