8DQ8
 
 | | The structure of NicA2 variant F104L/A107T/S146I/G317D/H368R/L449V/N462S in complex with N-methylmyosmine | | Descriptor: | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 1,2-ETHANEDIOL, Amine oxidase, ... | | Authors: | Wu, K, Dulchavsky, M, Li, J, Bardwell, J.C.A. | | Deposit date: | 2022-07-18 | | Release date: | 2023-07-26 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Directed evolution unlocks oxygen reactivity for a nicotine-degrading flavoenzyme.
Nat.Chem.Biol., 19, 2023
|
|
7C4A
 | | nicA2 with cofactor FAD | | Descriptor: | Amine oxidase, FLAVIN-ADENINE DINUCLEOTIDE | | Authors: | Xu, P, Zang, K. | | Deposit date: | 2020-05-15 | | Release date: | 2020-06-03 | | Last modified: | 2020-12-16 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Molecular Deceleration Regulates Toxicant Release to Prevent Cell Damage in Pseudomonas putida S16 (DSM 28022).
Mbio, 11, 2020
|
|
8DQ7
 | |
5TTJ
 | |
7C49
 | | nicA2 with cofactor FAD and substrate nicotine | | Descriptor: | 5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-2-ol, Amine oxidase, FLAVIN-ADENINE DINUCLEOTIDE | | Authors: | Xu, P, Zhang, K. | | Deposit date: | 2020-05-15 | | Release date: | 2020-06-03 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Molecular Deceleration Regulates Toxicant Release to Prevent Cell Damage in Pseudomonas putida S16 (DSM 28022).
Mbio, 11, 2020
|
|
7KHN
 | | NicA2 variant N462Y/W427Y in complex with (S)-nicotine | | Descriptor: | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, Amine oxidase, FLAVIN-ADENINE DINUCLEOTIDE | | Authors: | Tararina, M.A, Allen, K.N. | | Deposit date: | 2020-10-21 | | Release date: | 2021-02-03 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Fast Kinetics Reveals Rate-Limiting Oxidation and the Role of the Aromatic Cage in the Mechanism of the Nicotine-Degrading Enzyme NicA2.
Biochemistry, 60, 2021
|
|
8DSV
 | | The structure of NicA2 in complex with N-methylmyosmine | | Descriptor: | DI(HYDROXYETHYL)ETHER, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, FAD-dependent oxidoreductase, ... | | Authors: | Wu, K, Dulchavsky, M, Li, J, Bardwell, J.C.A. | | Deposit date: | 2022-07-22 | | Release date: | 2023-07-26 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Directed evolution unlocks oxygen reactivity for a nicotine-degrading flavoenzyme.
Nat.Chem.Biol., 19, 2023
|
|
5TTK
 | |
6C71
 | | Nicotine Oxidoreductase in Complex with S-nicotine | | Descriptor: | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, Amine oxidase, FLAVIN-ADENINE DINUCLEOTIDE | | Authors: | Tararina, M.A, Allen, K.N. | | Deposit date: | 2018-01-19 | | Release date: | 2018-07-11 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.649 Å) | | Cite: | Crystallography Coupled with Kinetic Analysis Provides Mechanistic Underpinnings of a Nicotine-Degrading Enzyme.
Biochemistry, 57, 2018
|
|
7KHO
 | | NicA2 variant N462V in complex with (S)-nicotine | | Descriptor: | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, Amine oxidase, FLAVIN-ADENINE DINUCLEOTIDE | | Authors: | Tararina, M.A, Allen, K.N. | | Deposit date: | 2020-10-21 | | Release date: | 2021-02-10 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.69 Å) | | Cite: | Fast Kinetics Reveals Rate-Limiting Oxidation and the Role of the Aromatic Cage in the Mechanism of the Nicotine-Degrading Enzyme NicA2.
Biochemistry, 60, 2021
|
|
