8Z50
 
 | | Crystal structure of the ASF1-H3T-H4 complex | | Descriptor: | Histone H3.1t, Histone H4, Histone chaperone ASF1A | | Authors: | Xu, L. | | Deposit date: | 2024-04-18 | | Release date: | 2024-07-03 | | Last modified: | 2024-07-10 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural insights into instability of the nucleosome driven by histone variant H3T.
Biochem.Biophys.Res.Commun., 727, 2024
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8GHN
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8GHM
 | | Hir1 WD40 domains and Asf1/H3/H4 | | Descriptor: | Histone H3, Histone H4, Histone chaperone, ... | | Authors: | Kim, H.J, Murakami, K. | | Deposit date: | 2023-03-10 | | Release date: | 2024-07-10 | | Last modified: | 2024-08-07 | | Method: | ELECTRON MICROSCOPY (12 Å) | | Cite: | Structure of the Hir histone chaperone complex.
Mol.Cell, 84, 2024
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8CJ3
 | | Urea-based foldamer inhibitor c3u_7 chimera in complex with ASF1 histone chaperone | | Descriptor: | Histone chaperone ASF1A, c3u_7 chimera inhibitor of histone chaperone ASF1 | | Authors: | Perrin, M.E, Li, B, Mbianda, J, Ropars, V, Legrand, P, Douat, C, Ochsenbein, F, Guichard, G. | | Deposit date: | 2023-02-11 | | Release date: | 2023-07-05 | | Last modified: | 2024-07-10 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Unexpected binding modes of inhibitors to the histone chaperone ASF1 revealed by a foldamer scanning approach.
Chem.Commun.(Camb.), 59, 2023
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8CJ2
 | | Urea-based foldamer inhibitor c3u_5 chimera in complex with ASF1 histone chaperone | | Descriptor: | GLYCEROL, Histone chaperone ASF1A, SULFATE ION, ... | | Authors: | Perrin, M.E, Li, B, Mbianda, J, Ropars, V, Legrand, P, Douat, C, Ochsenbein, F, Guichard, G. | | Deposit date: | 2023-02-11 | | Release date: | 2023-07-05 | | Last modified: | 2024-07-10 | | Method: | X-RAY DIFFRACTION (2.127 Å) | | Cite: | Unexpected binding modes of inhibitors to the histone chaperone ASF1 revealed by a foldamer scanning approach.
Chem.Commun.(Camb.), 59, 2023
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8CJ1
 | | Urea-based foldamer inhibitor c3u_3 chimera in complex with ASF1 histone chaperone | | Descriptor: | Histone chaperone ASF1A, c3u_3 chimera inhibitor of histone chaperone ASF1 | | Authors: | Perrin, M.E, Li, B, Mbianda, J, Ropars, V, Legrand, P, Douat, C, Ochsenbein, F, Guichard, G. | | Deposit date: | 2023-02-11 | | Release date: | 2023-07-05 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.564 Å) | | Cite: | Unexpected binding modes of inhibitors to the histone chaperone ASF1 revealed by a foldamer scanning approach.
Chem.Commun.(Camb.), 59, 2023
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8BV1
 | | Peptide inhibitor P4 in complex with ASF1 histone chaperone | | Descriptor: | GLYCEROL, Histone chaperone ASF1A, P4 peptide inhibitor of histone chaperone ASF1 | | Authors: | Perrin, M.E, Li, B, Mbianda, J, Ropars, V, Legrand, P, Douat, C, Ochsenbein, F, Guichard, G. | | Deposit date: | 2022-12-01 | | Release date: | 2023-07-05 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.834 Å) | | Cite: | Unexpected binding modes of inhibitors to the histone chaperone ASF1 revealed by a foldamer scanning approach.
Chem.Commun.(Camb.), 59, 2023
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7XAY
 | | Crystal structure of Hat1-Hat2-Asf1-H3-H4 | | Descriptor: | COENZYME A, Histone H3, Histone H4, ... | | Authors: | Yue, Y, Yang, W.S, Xu, R.M. | | Deposit date: | 2022-03-19 | | Release date: | 2022-05-18 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Topography of histone H3-H4 interaction with the Hat1-Hat2 acetyltransferase complex.
Genes Dev., 36, 2022
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7VCQ
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7V6Q
 | | Crystal structure of sNASP-ASF1A-H3.1-H4 complex | | Descriptor: | GLYCEROL, Histone H3.1, Histone H4, ... | | Authors: | Liu, C.P, Xu, R.M. | | Deposit date: | 2021-08-20 | | Release date: | 2021-12-29 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones.
Genes Dev., 35, 2021
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7V1M
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7UNK
 | | Structure of Importin-4 bound to the H3-H4-ASF1 histone-histone chaperone complex | | Descriptor: | Histone H3, Histone H4, Histone chaperone, ... | | Authors: | Bernardes, N.E, Chook, Y.M, Fung, H.Y.J, Chen, Z, Li, Y. | | Deposit date: | 2022-04-11 | | Release date: | 2022-09-21 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.45 Å) | | Cite: | Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7LO0
 | | Structure of human ASF1a in complex with a TLK2 peptide | | Descriptor: | Histone chaperone ASF1A, Serine/threonine-protein kinase tousled-like 2 | | Authors: | Simon, B, Calderwood, D, Turk, B.E, Boggon, T.J. | | Deposit date: | 2021-02-08 | | Release date: | 2022-02-16 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.
Nat Commun, 13, 2022
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7LNY
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6ZUF
 | | Urea-based Foldamer Inhibitor chimera C2 in complex with ASF1 Histone chaperone | | Descriptor: | C2 foldamer/peptide hybrid inhibitor of histone chaperone ASF1, GLYCEROL, Histone chaperone ASF1A, ... | | Authors: | Bakail, M, Mbianda, J, Perrin, E.M, Guerois, R, Legrand, P, Traore, S, Douat, C, Guichard, G, Ochsenbein, F. | | Deposit date: | 2020-07-22 | | Release date: | 2021-06-09 | | Last modified: | 2024-07-10 | | Method: | X-RAY DIFFRACTION (1.798 Å) | | Cite: | Optimal anchoring of a foldamer inhibitor of ASF1 histone chaperone through backbone plasticity.
Sci Adv, 7, 2021
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6O22
 | | Structure of Asf1-H3:H4-Rtt109-Vps75 histone chaperone-lysine acetyltransferase complex with the histone substrate. | | Descriptor: | Histone H3.2, Histone H4, Histone acetyltransferase RTT109, ... | | Authors: | Danilenko, N, Carlomagno, T, Kirkpatrick, J.P. | | Deposit date: | 2019-02-22 | | Release date: | 2019-07-31 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR, SOLUTION SCATTERING | | Cite: | Histone chaperone exploits intrinsic disorder to switch acetylation specificity.
Nat Commun, 10, 2019
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6F0Y
 | | Rtt109 peptide bound to Asf1 | | Descriptor: | Histone chaperone ASF1, histone acetyltransferase Rtt109 C-terminus | | Authors: | Lercher, L, Kirkpatrick, J.P, Carlomagno, T. | | Deposit date: | 2017-11-21 | | Release date: | 2017-12-27 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural characterization of the Asf1-Rtt109 interaction and its role in histone acetylation.
Nucleic Acids Res., 46, 2018
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6F0H
 | | Crystal structure ASF1-ip4 | | Descriptor: | CITRIC ACID, GLYCEROL, Histone chaperone ASF1A, ... | | Authors: | Bakail, M, Richet, N, Le Du, M.H, Andreani, J, Guerois, R, Ochsenbein, F. | | Deposit date: | 2017-11-20 | | Release date: | 2019-06-12 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1.
Cell Chem Biol, 26, 2019
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6F0G
 | | Crystal structure ASF1-ip3 | | Descriptor: | Histone chaperone ASF1A, SULFATE ION, ip3 | | Authors: | Gaubert, A, Guichard, B, Richet, N, Le Du, M.H, Andreani, J, Guerois, R, Ochsenbein, F. | | Deposit date: | 2017-11-20 | | Release date: | 2019-06-12 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1.
Cell Chem Biol, 26, 2019
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6F0F
 | | Crystal structure ASF1-ip2_s | | Descriptor: | Histone chaperone ASF1A, ip2_s | | Authors: | Gaubert, A, Guichard, B, Murciano, B, Le Du, M.H, Ochsenbein, F, Guerois, R, Andreani, J. | | Deposit date: | 2017-11-20 | | Release date: | 2019-06-12 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1.
Cell Chem Biol, 26, 2019
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6AZ2
 | | Crystal structure of Asf1-Fab 12E complex | | Descriptor: | Fab Heavy Chain, Fab Light Chain, Histone chaperone ASF1 | | Authors: | Bailey, L.J, Kossiakoff, A.A. | | Deposit date: | 2017-09-09 | | Release date: | 2018-01-10 | | Last modified: | 2018-02-14 | | Method: | X-RAY DIFFRACTION (2.477 Å) | | Cite: | Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
J. Mol. Biol., 430, 2018
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6AYZ
 | | Crystal structure of Asf1-Fab 12E complex | | Descriptor: | Fab Heavy Chain, Fab Light Chain, Histone chaperone ASF1 | | Authors: | Bailey, L.J, Kossiakoff, A.A. | | Deposit date: | 2017-09-08 | | Release date: | 2018-01-17 | | Last modified: | 2020-01-01 | | Method: | X-RAY DIFFRACTION (2.096 Å) | | Cite: | Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
J. Mol. Biol., 430, 2018
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6A6Y
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5ZBB
 | | Crystal structure of Rtt109-Asf1-H3-H4 complex | | Descriptor: | DI(HYDROXYETHYL)ETHER, DNA damage response protein Rtt109, putative, ... | | Authors: | Zhang, L, Serra-Cardona, A, Zhou, H, Wang, M, Yang, N, Zhang, Z, Xu, R.M. | | Deposit date: | 2018-02-10 | | Release date: | 2018-07-25 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109.
Cell, 174, 2018
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5ZBA
 | | Crystal structure of Rtt109-Asf1-H3-H4-CoA complex | | Descriptor: | COENZYME A, DNA damage response protein Rtt109, putative, ... | | Authors: | Zhang, L, Serra-Cardona, A, Zhou, H, Wang, M, Yang, N, Zhang, Z, Xu, R.M. | | Deposit date: | 2018-02-10 | | Release date: | 2018-07-25 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109.
Cell, 174, 2018
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