5JCW
 
 | | Crystal Structure of hGSTP1-1 with Glutathione Adduct of Phenethyl Isothiocyanate | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, CALCIUM ION, ... | | Authors: | Kumari, V, Ji, X. | | Deposit date: | 2016-04-15 | | Release date: | 2016-10-12 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.945 Å) | | Cite: | Irreversible Inhibition of Glutathione S-Transferase by Phenethyl Isothiocyanate (PEITC), a Dietary Cancer Chemopreventive Phytochemical.
Plos One, 11, 2016
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2MAH
 | | Solution structure of Smoothened | | Descriptor: | Protein smoothened | | Authors: | Rana, R, Lee, H, Zheng, J.J. | | Deposit date: | 2013-07-09 | | Release date: | 2014-03-05 | | Last modified: | 2024-11-20 | | Method: | SOLUTION NMR | | Cite: | Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling.
Nat Commun, 4, 2013
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2D0K
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2BCD
 | | X-ray crystal structure of Protein Phosphatase-1 with the marine toxin motuporin bound | | Descriptor: | BETA-MERCAPTOETHANOL, MANGANESE (II) ION, MOTUPORIN, ... | | Authors: | Maynes, J.T, Luu, H.A, Cherney, M.M, Andersen, R.J, Williams, D, Holmes, C.F, James, M.N. | | Deposit date: | 2005-10-19 | | Release date: | 2006-01-17 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Structures of Protein Phosphatase-1 Bound to Motuporin and Dihydromicrocystin-LA: Elucidation of the Mechanism of Enzyme Inhibition by Cyanobacterial Toxins.
J.Mol.Biol., 356, 2006
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2NB0
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1WXW
 | | Crystal structure of Tt1595, a putative SAM-dependent methyltransferase from Thermus thermophillus HB8 | | Descriptor: | HEXANE-1,6-DIOL, hypothetical protein TTHA1280 | | Authors: | Pioszak, A.A, Murayama, K, Nakagawa, N, Ebihara, A, Kuramitsu, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-02-02 | | Release date: | 2005-08-02 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Structures of a putative RNA 5-methyluridine methyltransferase, Thermus thermophilus TTHA1280, and its complex with S-adenosyl-L-homocysteine.
Acta Crystallogr.,Sect.F, 61, 2005
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6DXF
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7SOH
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4JYD
 | | X-ray snapshots of possible intermediates in the time course of synthesis and degradation of protein-bound Fe4S4 clusters. | | Descriptor: | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, BROMIDE ION, CHAPSO, ... | | Authors: | Nicolet, Y, Rohac, R, Martin, L, Fontecilla-Camps, J.C. | | Deposit date: | 2013-03-29 | | Release date: | 2013-05-01 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | X-ray snapshots of possible intermediates in the time course of synthesis and degradation of protein-bound Fe4S4 clusters.
Proc.Natl.Acad.Sci.USA, 110, 2013
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2OTT
 | | Crystal structure of CD5_DIII | | Descriptor: | T-cell surface glycoprotein CD5 | | Authors: | Rodamilans, B. | | Deposit date: | 2007-02-09 | | Release date: | 2007-03-13 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of the third extracellular domain of CD5 reveals the fold of a group B scavenger cysteine-rich receptor domain.
J.Biol.Chem., 282, 2007
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8GYB
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6DXE
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8G9Z
 | | High-resolution crystal structure of the human selenomethionine-derived SepSecS-tRNASec complex | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, O-phosphoseryl-tRNA(Sec) selenium transferase, ... | | Authors: | Puppala, A, Simonovic, M, Castillo Suchkou, J. | | Deposit date: | 2023-02-22 | | Release date: | 2023-04-05 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Structural basis for the tRNA-dependent activation of the terminal complex of selenocysteine synthesis in humans.
Nucleic Acids Res., 51, 2023
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7R50
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4JYE
 | | X-ray snapshots of possible intermediates in the time course of synthesis and degradation of protein-bound Fe4S4 clusters. | | Descriptor: | BROMIDE ION, Biotin synthetase, putative, ... | | Authors: | Nicolet, Y, Rohac, R, Martin, L, Fontecilla-Camps, J.C. | | Deposit date: | 2013-03-29 | | Release date: | 2013-05-01 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | X-ray snapshots of possible intermediates in the time course of synthesis and degradation of protein-bound Fe4S4 clusters.
Proc.Natl.Acad.Sci.USA, 110, 2013
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6QH4
 | | Crystal structure of human Methylmalonyl-CoA epimerase (MCEE) p.Arg143Cys variant | | Descriptor: | COBALT (II) ION, Methylmalonyl-CoA epimerase, mitochondrial | | Authors: | Bailey, H.J, Chaikuid, A, Krysztofinska, E, Froese, D.S, Sorrell, F.J, Diaz-Saez, L, Kennedy, E, Edwards, A.M, Bountra, C, Yue, W.W. | | Deposit date: | 2019-01-15 | | Release date: | 2019-02-27 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.922 Å) | | Cite: | Crystal structure of human Methylmalonyl-CoA epimerase (MCEE) p.Arg143Cys variant
To Be Published
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8R7B
 | | SARS-CoV-2 NSP14 in complex with SAH and TDI-015051 | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Guanine-N7 methyltransferase nsp14, ... | | Authors: | Meyer, C, Garzia, A, Miller, M, Huggins, D.J, Myers, R.W, Liverton, N, Kargman, S, Nitsche, J, Ganichkin, O, Steinbacher, S, Meinke, P.T, Tuschl, T. | | Deposit date: | 2023-11-24 | | Release date: | 2024-10-23 | | Last modified: | 2025-02-05 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase.
Nature, 637, 2025
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5KOK
 | | Pavine N-methyltransferase in complex with Tetrahydropapaverine and S-adenosylhomocysteine pH 7.25 | | Descriptor: | (1~{R})-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline, (1~{S})-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline, Pavine N-methyltransferase, ... | | Authors: | Torres, M.A, Hoffarth, E, Eugenio, L, Savtchouk, J, Chen, X, Morris, J, Facchini, P.J, Ng, K.K.S. | | Deposit date: | 2016-06-30 | | Release date: | 2016-09-07 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.792 Å) | | Cite: | Structural and Functional Studies of Pavine N-Methyltransferase from Thalictrum flavum Reveal Novel Insights into Substrate Recognition and Catalytic Mechanism.
J.Biol.Chem., 291, 2016
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5CGF
 | | Yeast 20S proteasome beta5-G48C mutant | | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Probable proteasome subunit alpha type-7, ... | | Authors: | Dubiella, C, Groll, M. | | Deposit date: | 2015-07-09 | | Release date: | 2015-11-25 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Selective Inhibition of the Immunoproteasome by Structure-Based Targeting of a Non-catalytic Cysteine.
Angew.Chem.Int.Ed.Engl., 54, 2015
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8KDZ
 | | DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-Adenosyl-L-homocysteine and Caffeic acid phenethyl ester | | Descriptor: | 2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate, S-ADENOSYL-L-HOMOCYSTEINE, methyltransferase | | Authors: | Bhutkar, M, Kumar, A, Tomar, S, Kumar, P. | | Deposit date: | 2023-08-10 | | Release date: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Deciphering Antiviral Mechanisms of Herbacetin and Caffeic acid phenethyl ester against Chikungunya and Dengue virus, with insights into Dengue methyltransferase-CAPE crystal structure
To Be Published
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5KPG
 | | Pavine N-methyltransferase in complex with S-adenosylhomocysteine pH 7 | | Descriptor: | Pavine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Torres, M.A, Hoffarth, E, Eugenio, L, Savtchouk, J, Chen, X, Morris, J, Facchini, P.J, Ng, K.K.S. | | Deposit date: | 2016-07-04 | | Release date: | 2016-09-07 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural and Functional Studies of Pavine N-Methyltransferase from Thalictrum flavum Reveal Novel Insights into Substrate Recognition and Catalytic Mechanism.
J.Biol.Chem., 291, 2016
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2W5Z
 | | Ternary Complex of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine and histone peptide. | | Descriptor: | GLYCEROL, HISTONE PEPTIDE, HISTONE-LYSINE N-METHYLTRANSFERASE HRX, ... | | Authors: | Southall, S.M, Wong, P.S, Odho, Z, Roe, S.M, Wilson, J.R. | | Deposit date: | 2008-12-15 | | Release date: | 2009-02-10 | | Last modified: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural Basis for the Requirement of Additional Factors for Mll1 Set Domain Activity and Recognition of Epigenetic Marks.
Mol.Cell, 33, 2009
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8UJG
 | | X-ray crystal structure of Toxoplasma gondii GalNAc-T3 in complex with UDP-GalNAc, Mn2+, and the mono-glycopeptide Srs13.2 | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | Authors: | Kumar, P, Samara, N.L. | | Deposit date: | 2023-10-11 | | Release date: | 2024-05-15 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | A Toxoplasma gondii O-glycosyltransferase that modulates bradyzoite cyst wall rigidity is distinct from host homologues.
Nat Commun, 15, 2024
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8UI1
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8UJE
 | | X-ray crystal structure of Toxoplasma gondii GalNAc-T3 in complex with UDP-GalNAc, Mn2+, and Muc5AC-3,13 | | Descriptor: | DI(HYDROXYETHYL)ETHER, Glycosyl transferase, MANGANESE (II) ION, ... | | Authors: | Kumar, P, Samara, N.L. | | Deposit date: | 2023-10-11 | | Release date: | 2024-05-15 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A Toxoplasma gondii O-glycosyltransferase that modulates bradyzoite cyst wall rigidity is distinct from host homologues.
Nat Commun, 15, 2024
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