8T6B
| Human VMAT2 in complex with serotonin | Descriptor: | SEROTONIN, Synaptic vesicular amine transporter | Authors: | Pidathala, S, Dai, Y, Lee, C.H. | Deposit date: | 2023-06-15 | Release date: | 2023-11-01 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.72 Å) | Cite: | Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2. Nature, 623, 2023
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8T6A
| Human VMAT2 in complex with reserpine | Descriptor: | Synaptic vesicular amine transporter, reserpine | Authors: | Pidathala, S, Dai, Y, Lee, C.H. | Deposit date: | 2023-06-15 | Release date: | 2023-11-01 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2. Nature, 623, 2023
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4NAA
| Crystal structure of UVB photoreceptor UVR8 from Arabidopsis thaliana and UV-induced structural changes at 120K | Descriptor: | MAGNESIUM ION, Ultraviolet-B receptor UVR8 | Authors: | Yang, X, Zeng, X, Ren, Z, Zhao, K.H. | Deposit date: | 2013-10-22 | Release date: | 2016-10-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Dynamic Crystallography Reveals Early Signalling Events in Ultraviolet Photoreceptor UVR8. Nat Plants, 1, 2015
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8IOA
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2XNG
| Structure of Aurora-A bound to a selective imidazopyrazine inhibitor | Descriptor: | N-(3-{3-chloro-8-[(4-morpholin-4-ylphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzyl)methanesulfonamide, SERINE/THREONINE-PROTEIN KINASE 6 | Authors: | Kosmopoulou, M, Bayliss, R. | Deposit date: | 2010-08-02 | Release date: | 2010-09-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.605 Å) | Cite: | Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells. Bioorg. Med. Chem. Lett., 20, 2010
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2BG9
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4NVA
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4NVL
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2BLO
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1CKI
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4NVH
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1D5A
| CRYSTAL STRUCTURE OF AN ARCHAEBACTERIAL DNA POLYMERASE D.TOK. DEPOSITION OF SECOND NATIVE STRUCTURE AT 2.4 ANGSTROM | Descriptor: | MAGNESIUM ION, PROTEIN (DNA POLYMERASE), SULFATE ION | Authors: | Zhao, Y, Jeruzalmi, D, Leighton, L, Lasken, R, Kuriyan, J. | Deposit date: | 1999-10-06 | Release date: | 2000-03-24 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of an archaebacterial DNA polymerase. Structure Fold.Des., 7, 1999
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2IK8
| Crystal structure of the heterodimeric complex of human RGS16 and activated Gi alpha 1 | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ... | Authors: | Soundararajan, M, Turnbull, A.P, Papagrigoriou, E, Debreczeni, J, Gorrec, F, von Delft, F, Weigelt, J, Edwards, A, Arrowsmith, C, Sundstrom, M, Doyle, D.A, Structural Genomics Consortium (SGC) | Deposit date: | 2006-10-02 | Release date: | 2006-11-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc.Natl.Acad.Sci.Usa, 105, 2008
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8RCL
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2BGL
| X-Ray structure of binary-Secoisolariciresinol Dehydrogenase | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM), RHIZOME SECOISOLARICIRESINOL DEHYDROGENASE | Authors: | Youn, B, Moinuddin, S.G, Davin, L.B, Lewis, N.G, Kang, C. | Deposit date: | 2004-12-23 | Release date: | 2005-01-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structures of Apo-Form and Binary/Ternary Complexes of Podophyllum Secoisolariciresinol Dehydrogenase, an Enzyme Involved in Formation of Health-Protecting and Plant Defense Lignans J.Biol.Chem., 280, 2005
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2BHJ
| murine iNO synthase with coumarin inhibitor | Descriptor: | 7,8-DIHYDROBIOPTERIN, NITRIC OXIDE SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Mathieu, M, Guilloteau, J.P. | Deposit date: | 2005-01-12 | Release date: | 2005-03-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Design, Synthesis and Characterization of a Novel Class of Coumarin-Based Inhibitors of Inducible Nitric Oxide Synthase Bioorg.Med.Chem., 13, 2005
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2XNS
| Crystal Structure Of Human G alpha i1 Bound To A Designed Helical Peptide Derived From The Goloco Motif Of RGS14 | Descriptor: | GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-1, GUANOSINE-5'-DIPHOSPHATE, REGULATOR OF G-PROTEIN SIGNALING 14, ... | Authors: | Bosch, D, Sammond, D.W, Butterfoss, G.L, Machius, M, Siderovski, D.P, Kuhlman, B. | Deposit date: | 2010-08-05 | Release date: | 2011-06-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.41 Å) | Cite: | Computational Design of the Sequence and Structure of a Protein-Binding Peptide. J.Am.Chem.Soc., 133, 2011
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2J4L
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8RCM
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2Y3Q
| 1.55A structure of apo bacterioferritin from E. coli | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, BACTERIOFERRITIN, ... | Authors: | Hough, M.A, Antonyuk, S.V. | Deposit date: | 2010-12-22 | Release date: | 2011-02-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Monitoring and Validating Active Site Redox States in Protein Crystals. Biochim.Biophys.Acta, 1814, 2011
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4PAO
| A conserved phenylalanine as relay between the 5 helix and the GDP binding region of heterotrimeric G protein | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, MAGNESIUM ION | Authors: | Kaya, A.I, Lokits, A.D, Gilbert, J, Iverson, T.M, Meiler, J, Hamm, H.E. | Deposit date: | 2014-04-09 | Release date: | 2014-07-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.003 Å) | Cite: | A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit. J.Biol.Chem., 289, 2014
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4P3Q
| Room-temperature WT DHFR, time-averaged ensemble | Descriptor: | CALCIUM ION, Dihydrofolate reductase, FOLIC ACID, ... | Authors: | Keedy, D.A, van den Bedem, H, Fraser, J.S. | Deposit date: | 2014-03-10 | Release date: | 2014-05-14 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.351 Å) | Cite: | Crystal Cryocooling Distorts Conformational Heterogeneity in a Model Michaelis Complex of DHFR. Structure, 22, 2014
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2XNE
| Structure of Aurora-A bound to an imidazopyrazine inhibitor | Descriptor: | 3-chloro-N-(4-morpholin-4-ylphenyl)-6-pyridin-3-ylimidazo[1,2-a]pyrazin-8-amine, SERINE/THREONINE-PROTEIN KINASE 6 | Authors: | Kosmopoulou, M, Bayliss, R. | Deposit date: | 2010-08-02 | Release date: | 2010-09-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells. Bioorg. Med. Chem. Lett., 20, 2010
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2XRW
| Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4 | Descriptor: | GLYCEROL, MITOGEN-ACTIVATED PROTEIN KINASE 8, NUCLEAR FACTOR OF ACTIVATED T-CELLS, ... | Authors: | Barkai, T, Toeoroe, I, Garai, A, Remenyi, A. | Deposit date: | 2010-09-23 | Release date: | 2011-09-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Specificity of Linear Motifs that Bind to a Common Mitogen-Activated Protein Kinase Docking Groove. Sci. Signal, 5, 2012
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2BLQ
| Elastase After A High Dose X-Ray "Burn" | Descriptor: | CALCIUM ION, ELASTASE 1, SULFATE ION | Authors: | Nanao, M.H, Ravelli, R.B. | Deposit date: | 2005-03-08 | Release date: | 2005-09-07 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Improving Radiation-Damage Substructures for Rip. Acta Crystallogr.,Sect.D, 61, 2005
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