3TPD
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![BU of 3tpd by Molmil](/molmil-images/mine/3tpd) | Structure of pHipA, monoclinic form | Descriptor: | CHLORIDE ION, PHOSPHATE ION, Serine/threonine-protein kinase HipA | Authors: | schumacher, M.A, link, T, Brennan, R.G. | Deposit date: | 2011-09-07 | Release date: | 2012-10-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Role of Unusual P Loop Ejection and Autophosphorylation in HipA-Mediated Persistence and Multidrug Tolerance. Cell Rep, 2, 2012
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4BJT
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![BU of 4bjt by Molmil](/molmil-images/mine/4bjt) | Crystal structure of the Rap1 C-terminal domain (Rap1-RCT) in complex with the Rap1 binding module of Rif1 (Rif1-RBM) | Descriptor: | 1,2-ETHANEDIOL, DNA-BINDING PROTEIN RAP1, TELOMERE LENGTH REGULATOR PROTEIN RIF1 | Authors: | Shi, T, Bunker, R.D, Gut, H, Scrima, A, Thoma, N.H. | Deposit date: | 2013-04-19 | Release date: | 2013-06-19 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Rif1 and Rif2 Shape Telomere Funcation and Architecture Through Multivalent RAP1 Interactions Cell(Cambridge,Mass.), 153, 2013
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3TPV
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![BU of 3tpv by Molmil](/molmil-images/mine/3tpv) | Structure of pHipA bound to ADP | Descriptor: | ADENINE, SULFATE ION, Serine/threonine-protein kinase HipA | Authors: | Schumacher, M.A, Link, T.M, Brennan, R.G. | Deposit date: | 2011-09-08 | Release date: | 2012-10-03 | Last modified: | 2012-10-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Role of Unusual P Loop Ejection and Autophosphorylation in HipA-Mediated Persistence and Multidrug Tolerance. Cell Rep, 2, 2012
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4BJ6
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![BU of 4bj6 by Molmil](/molmil-images/mine/4bj6) | Crystal structure Rif2 in complex with the C-terminal domain of Rap1 (Rap1-RCT) | Descriptor: | DNA-BINDING PROTEIN RAP1, RAP1-INTERACTING FACTOR 2, SULFATE ION | Authors: | Shi, T, Bunker, R.D, Gut, H, Scrima, A, Thoma, N.H. | Deposit date: | 2013-04-16 | Release date: | 2013-06-19 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.26 Å) | Cite: | Rif1 and Rif2 Shape Telomere Funcation and Architecture Through Multivalent RAP1 Interactions Cell(Cambridge,Mass.), 153, 2013
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7ZLO
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![BU of 7zlo by Molmil](/molmil-images/mine/7zlo) | Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 12 | Descriptor: | Elongin-B, Elongin-C, Suppressor of cytokine signaling 2, ... | Authors: | Ramachandran, S, Ciulli, A, Makukhin, N. | Deposit date: | 2022-04-15 | Release date: | 2023-04-26 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14, 2023
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7ZLP
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![BU of 7zlp by Molmil](/molmil-images/mine/7zlp) | Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 9 | Descriptor: | Elongin-B, Elongin-C, PHOSPHATE ION, ... | Authors: | Ramachandran, S, Ciulli, A, Makukhin, N. | Deposit date: | 2022-04-15 | Release date: | 2023-04-26 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14, 2023
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7ZLN
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![BU of 7zln by Molmil](/molmil-images/mine/7zln) | Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 11 | Descriptor: | Elongin-B, Elongin-C, Suppressor of cytokine signaling 2, ... | Authors: | Ramachandran, S, Ciulli, A, Makukhin, N. | Deposit date: | 2022-04-15 | Release date: | 2023-04-26 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14, 2023
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7ZLS
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![BU of 7zls by Molmil](/molmil-images/mine/7zls) | co-crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 13 | Descriptor: | 1,2-ETHANEDIOL, Elongin-B, Elongin-C, ... | Authors: | Ramachandran, S, Ciulli, A, Makukhin, N. | Deposit date: | 2022-04-15 | Release date: | 2023-04-26 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14, 2023
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7ZLR
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![BU of 7zlr by Molmil](/molmil-images/mine/7zlr) | Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 13 | Descriptor: | Elongin-B, Elongin-C, Suppressor of cytokine signaling 2, ... | Authors: | Ramachandran, S, Ciulli, A, Makukhin, N. | Deposit date: | 2022-04-15 | Release date: | 2023-04-26 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14, 2023
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7ZLM
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![BU of 7zlm by Molmil](/molmil-images/mine/7zlm) | Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound MN551 | Descriptor: | Elongin-B, Elongin-C, Suppressor of cytokine signaling 2, ... | Authors: | Ramachandran, S, Ciulli, A, Makukhin, N. | Deposit date: | 2022-04-15 | Release date: | 2023-04-26 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14, 2023
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3SXK
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![BU of 3sxk by Molmil](/molmil-images/mine/3sxk) | |
3S7A
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![BU of 3s7a by Molmil](/molmil-images/mine/3s7a) | Human dihydrofolate reductase binary complex with PT684 | Descriptor: | 4-({5-[(2,4-diaminopteridin-6-yl)methyl]-5H-dibenzo[b,f]azepin-2-yl}oxy)butanoic acid, Dihydrofolate reductase, SULFATE ION | Authors: | Cody, V, Pace, J, Nowak, J. | Deposit date: | 2011-05-26 | Release date: | 2011-10-05 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural analysis of human dihydrofolate reductase as a binary complex with the potent and selective inhibitor 2,4-diamino-6-{2'-O-(3-carboxypropyl)oxydibenz[b,f]-azepin-5-yl}methylpteridine reveals an unusual binding mode. Acta Crystallogr.,Sect.D, 67, 2011
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4BRW
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![BU of 4brw by Molmil](/molmil-images/mine/4brw) | Crystal structure of the yeast Dhh1-Pat1 complex | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ATP-DEPENDENT RNA HELICASE DHH1, DNA TOPOISOMERASE 2-ASSOCIATED PROTEIN PAT1, ... | Authors: | Sharif, H, Ozgur, S, Sharma, K, Basquin, C, Urlaub, H, Conti, E. | Deposit date: | 2013-06-05 | Release date: | 2013-07-24 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.795 Å) | Cite: | Structural Analysis of the Yeast Dhh1-Pat1 Complex Reveals How Dhh1 Engages Pat1, Edc3 and RNA in Mutually Exclusive Interactions Nucleic Acids Res., 41, 2013
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3SN2
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![BU of 3sn2 by Molmil](/molmil-images/mine/3sn2) | |
3SNP
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![BU of 3snp by Molmil](/molmil-images/mine/3snp) | |
3UKG
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![BU of 3ukg by Molmil](/molmil-images/mine/3ukg) | Crystal structure of Rap1/DNA complex | Descriptor: | CALCIUM ION, DNA-binding protein RAP1, telomeric DNA | Authors: | Matot, B, Le Bihan, Y.-V, Gasparini, S, LeDu, M.H. | Deposit date: | 2011-11-09 | Release date: | 2011-12-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | The orientation of the C-terminal domain of the Saccharomyces cerevisiae Rap1 protein is determined by its binding to DNA. Nucleic Acids Res., 40, 2012
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3TPT
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![BU of 3tpt by Molmil](/molmil-images/mine/3tpt) | Structure of HipA(D309Q) bound to ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, SULFATE ION, ... | Authors: | schumacher, M.A, link, T, Brennan, R.G. | Deposit date: | 2011-09-08 | Release date: | 2012-10-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Role of Unusual P Loop Ejection and Autophosphorylation in HipA-Mediated Persistence and Multidrug Tolerance. Cell Rep, 2, 2012
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3T1B
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![BU of 3t1b by Molmil](/molmil-images/mine/3t1b) | Crystal structure of the full-length AphB N100E variant | Descriptor: | Transcriptional regulator, LysR family | Authors: | Taylor, J.L, De Silva, R.S, Kovacikova, G, Lin, W, Taylor, R.K, Skorupski, K, Kull, F.J. | Deposit date: | 2011-07-21 | Release date: | 2011-11-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The crystal structure of AphB, a virulence gene activator from Vibrio cholerae, reveals residues that influence its response to oxygen and pH. Mol.Microbiol., 83, 2012
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3SXM
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![BU of 3sxm by Molmil](/molmil-images/mine/3sxm) | |
3SXY
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![BU of 3sxy by Molmil](/molmil-images/mine/3sxy) | |
3SZP
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![BU of 3szp by Molmil](/molmil-images/mine/3szp) | Full-length structure of the Vibrio cholerae virulence activator, AphB, a member of the LTTR protein family | Descriptor: | Transcriptional regulator, LysR family | Authors: | Taylor, J.L, De Silva, R.S, Kovacikova, G, Lin, W, Taylor, R.K, Skorupski, K, Kull, F.J. | Deposit date: | 2011-07-19 | Release date: | 2011-11-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.202 Å) | Cite: | The crystal structure of AphB, a virulence gene activator from Vibrio cholerae, reveals residues that influence its response to oxygen and pH. Mol.Microbiol., 83, 2012
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3SXZ
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![BU of 3sxz by Molmil](/molmil-images/mine/3sxz) | |
3UA4
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![BU of 3ua4 by Molmil](/molmil-images/mine/3ua4) | Crystal Structure of Protein Arginine Methyltransferase PRMT5 | Descriptor: | GLYCEROL, Protein arginine N-methyltransferase 5 | Authors: | Sun, L, Wang, M, Lv, Z, Yang, N, Liu, Y, Bao, S, Gong, W, Xu, R.M. | Deposit date: | 2011-10-21 | Release date: | 2011-12-14 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.005 Å) | Cite: | Structural insights into protein arginine symmetric dimethylation by PRMT5 Proc.Natl.Acad.Sci.USA, 108, 2011
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3TPB
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![BU of 3tpb by Molmil](/molmil-images/mine/3tpb) | Structure of HipA(S150A) | Descriptor: | CHLORIDE ION, PHOSPHATE ION, Serine/threonine-protein kinase HipA | Authors: | schumacher, M.A. | Deposit date: | 2011-09-07 | Release date: | 2012-10-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Role of Unusual P Loop Ejection and Autophosphorylation in HipA-Mediated Persistence and Multidrug Tolerance. Cell Rep, 2, 2012
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4DDR
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![BU of 4ddr by Molmil](/molmil-images/mine/4ddr) | Human dihydrofolate reductase complexed with NADPH and P218 | Descriptor: | 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Yuthavong, Y, Tarnchompoo, B, Vilaivan, T, Chitnumsub, P, Kamchonwongpaisan, S, Charman, S.A, McLennan, D.N, White, K.L, Vivas, L, Bongard, E, Thongphanchang, C, Taweechai, S, Vanichtanankul, J, Rattanajak, R, Arwon, U, Fantauzzi, P, Yuvaniyama, J, Charman, W.N, Matthews, D. | Deposit date: | 2012-01-19 | Release date: | 2012-11-14 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target Proc.Natl.Acad.Sci.USA, 109, 2012
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