5EI3
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![BU of 5ei3 by Molmil](/molmil-images/mine/5ei3) | Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | Descriptor: | Eukaryotic translation initiation factor 4 gamma, Eukaryotic translation initiation factor 4E, SULFATE ION, ... | Authors: | Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. | Deposit date: | 2015-10-29 | Release date: | 2016-09-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124, 2016
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5GAG
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![BU of 5gag by Molmil](/molmil-images/mine/5gag) | RNC in complex with SRP-SR in the closed state | Descriptor: | 1A9L SS, 23S rRNA, 50S ribosomal protein L10, ... | Authors: | Jomaa, A, Boehringer, D, Leibundgut, M, Ban, N. | Deposit date: | 2015-11-26 | Release date: | 2016-01-27 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon. Nat Commun, 7, 2016
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5FCI
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![BU of 5fci by Molmil](/molmil-images/mine/5fci) | Structure of the vacant uL3 W255C mutant 80S yeast ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Mailliot, J, Garreau de Loubresse, N, Yusupova, G, Dinman, J.D, Yusupov, M. | Deposit date: | 2015-12-15 | Release date: | 2016-05-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Crystal Structures of the uL3 Mutant Ribosome: Illustration of the Importance of Ribosomal Proteins for Translation Efficiency. J.Mol.Biol., 428, 2016
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5GAF
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![BU of 5gaf by Molmil](/molmil-images/mine/5gaf) | RNC in complex with SRP | Descriptor: | 1A9L SS, 23S ribosomal RNA, 50S ribosomal protein L10, ... | Authors: | Jomaa, A, Boehringer, D, Leibundgut, M, Ban, N. | Deposit date: | 2015-11-25 | Release date: | 2016-02-03 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon Nat Commun, 7, 2016
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5DOX
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![BU of 5dox by Molmil](/molmil-images/mine/5dox) | Crystal structure of the Thermus thermophilus 70S ribosome in complex with Hygromycin-A at 3.1A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Polikanov, Y.S, Starosta, A.L, Juette, M.F, Altman, R.B, Terry, D.S, Lu, W, Burnett, B.J, Dinos, G, Reynolds, K, Blanchard, S.C, Steitz, T.A, Wilson, D.N. | Deposit date: | 2015-09-11 | Release date: | 2015-12-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A. Mol.Cell, 58, 2015
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5EKV
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![BU of 5ekv by Molmil](/molmil-images/mine/5ekv) | Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | Descriptor: | 3-[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione, Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1 | Authors: | Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. | Deposit date: | 2015-11-04 | Release date: | 2016-09-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.61 Å) | Cite: | Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124, 2016
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5EL5
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![BU of 5el5 by Molmil](/molmil-images/mine/5el5) | Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Rozov, A, Demeshkina, N, Khusainov, I, Yusupov, M, Yusupova, G. | Deposit date: | 2015-11-04 | Release date: | 2016-01-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code. Nat Commun, 7, 2016
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5H2F
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![BU of 5h2f by Molmil](/molmil-images/mine/5h2f) | Crystal structure of the PsbM-deletion mutant of photosystem II | Descriptor: | (3R)-beta,beta-caroten-3-ol, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... | Authors: | Uto, S, Kawakami, K, Umena, Y, Iwai, M, Ikeuchi, M, Shen, J.R, Kamiya, N. | Deposit date: | 2016-10-15 | Release date: | 2017-03-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mutual relationships between structural and functional changes in a PsbM-deletion mutant of photosystem II. Faraday Discuss., 198, 2017
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5GAH
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![BU of 5gah by Molmil](/molmil-images/mine/5gah) | RNC in complex with SRP with detached NG domain | Descriptor: | 1A9L SS, 23S rRNA, 50S ribosomal protein L10, ... | Authors: | Jomaa, A, Boehringer, D, Leibundgut, M, Ban, N. | Deposit date: | 2015-11-26 | Release date: | 2016-01-27 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon. Nat Commun, 7, 2016
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5EL6
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![BU of 5el6 by Molmil](/molmil-images/mine/5el6) | Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position and antibiotic paromomycin | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Rozov, A, Demeshkina, N, Khusainov, I, Yusupov, M, Yusupova, G. | Deposit date: | 2015-11-04 | Release date: | 2016-01-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code. Nat Commun, 7, 2016
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5EHC
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![BU of 5ehc by Molmil](/molmil-images/mine/5ehc) | Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | Descriptor: | 3-[[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-7-[(3-chlorophenyl)methyl]-6-oxidanylidene-1~{H}-purin-7-ium-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione, Eukaryotic translation initiation factor 4 gamma 1, Eukaryotic translation initiation factor 4E | Authors: | Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. | Deposit date: | 2015-10-28 | Release date: | 2016-09-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124, 2016
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5E7K
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![BU of 5e7k by Molmil](/molmil-images/mine/5e7k) | Structure of T. thermophilus 70S ribosome complex with mRNA and cognate tRNALys in the A-site | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Rozov, A, Demeshkina, N, Khusainov, I, Yusupov, M, Yusupova, G. | Deposit date: | 2015-10-12 | Release date: | 2016-01-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code. Nat Commun, 7, 2016
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5GAD
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![BU of 5gad by Molmil](/molmil-images/mine/5gad) | RNC-SRP-SR complex early state | Descriptor: | 1A9L SS, 23S rRNA, 50S ribosomal protein L10, ... | Authors: | Jomaa, A, Boehringer, D, Leibundgut, M, Ban, N. | Deposit date: | 2015-11-24 | Release date: | 2016-01-27 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon. Nat Commun, 7, 2016
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8BN3
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![BU of 8bn3 by Molmil](/molmil-images/mine/8bn3) | Yeast 80S, ES7s delta, eIF5A, Stm1 containing | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | Authors: | Dimitrova-Paternoga, L, Paternoga, H, Wilson, D.N. | Deposit date: | 2022-11-12 | Release date: | 2024-01-10 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Evolving precision: rRNA expansion segment 7S modulates translation velocity and accuracy in eukaryal ribosomes. Nucleic Acids Res., 52, 2024
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7A4H
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![BU of 7a4h by Molmil](/molmil-images/mine/7a4h) | |
7A4G
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![BU of 7a4g by Molmil](/molmil-images/mine/7a4g) | |
8CRX
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![BU of 8crx by Molmil](/molmil-images/mine/8crx) | Cutibacterium acnes 70S ribosome with mRNA, P-site tRNA and Sarecycline bound | Descriptor: | 23S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Lomakin, I.B, Devarkar, S.C, Bunick, C.G. | Deposit date: | 2022-05-12 | Release date: | 2023-03-22 | Last modified: | 2023-04-19 | Method: | ELECTRON MICROSCOPY (2.78 Å) | Cite: | Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism. Nucleic Acids Res., 51, 2023
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8CAM
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![BU of 8cam by Molmil](/molmil-images/mine/8cam) | Evernimicin bound to the 50S subunit | Descriptor: | 23S rRNA, 50S ribosomal protein L15, 50S ribosomal protein L25, ... | Authors: | Paternoga, H, Crowe-McAuliffe, C, Novacek, J, Wilson, D.N. | Deposit date: | 2023-01-24 | Release date: | 2023-07-26 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (1.86 Å) | Cite: | Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
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7AC7
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![BU of 7ac7 by Molmil](/molmil-images/mine/7ac7) | Structure of accomodated trans-translation complex on E. Coli stalled ribosome. | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Guyomar, C, D'Urso, G, Chat, S, Giudice, E, Gillet, R. | Deposit date: | 2020-09-10 | Release date: | 2021-08-18 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Structures of tmRNA and SmpB as they transit through the ribosome. Nat Commun, 12, 2021
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7A0S
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![BU of 7a0s by Molmil](/molmil-images/mine/7a0s) | 50S Deinococcus radiodurans ribosome bounded with mycinamicin I | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | Authors: | Breiner, E, Eyal, Z, Matzov, D, Halfon, Y, Cimicata, G, Rozenberg, H, Zimmerman, E, Bashan, A, Yonath, A. | Deposit date: | 2020-08-10 | Release date: | 2021-08-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.22 Å) | Cite: | Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida. Nucleic Acids Res., 49, 2021
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7A0R
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![BU of 7a0r by Molmil](/molmil-images/mine/7a0r) | 50S Deinococcus radiodurans ribosome bounded with mycinamicin I | Descriptor: | 50S ribosomal protein L13, 50S ribosomal protein L14, 50S ribosomal protein L15, ... | Authors: | Breiner, E, Eyal, Z, Matzov, D, Halfon, Y, Cimicata, G, Rozenberg, H, Zimmerman, E, Bashan, A, Yonath, A. | Deposit date: | 2020-08-10 | Release date: | 2021-08-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida. Nucleic Acids Res., 49, 2021
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8CKB
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![BU of 8ckb by Molmil](/molmil-images/mine/8ckb) | Asymmetric reconstruction of the crAss001 virion | Descriptor: | Auxiliary capsid protein gp36, Cargo protein 1 gp45, Head fiber dimer protein gp29, ... | Authors: | Bayfield, O.W, Shkoporov, A.N, Yutin, N, Khokhlova, E.V, Smith, J.L.R, Hawkins, D.E.D.P, Koonin, E.V, Hill, C, Antson, A.A. | Deposit date: | 2023-02-16 | Release date: | 2023-11-22 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.39 Å) | Cite: | Structural atlas of the most abundant human gut virus Nature
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8C3A
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![BU of 8c3a by Molmil](/molmil-images/mine/8c3a) | Crystal structure of ailanthone bound to the Candida albicans 80S ribosome | Descriptor: | 18S, 25S, 3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-glucopyranose, ... | Authors: | Kolosova, O, Zgadzay, Y, Yusupov, M. | Deposit date: | 2022-12-23 | Release date: | 2024-01-10 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | New crystal system to promote screening for new eukaryotic inhibitors To Be Published
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7B5K
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![BU of 7b5k by Molmil](/molmil-images/mine/7b5k) | E. coli 70S containing suppressor tRNA in the A-site stabilized by a Negamycin analogue and P-site tRNA-nascent chain. | Descriptor: | 16S rRNA, 2-[[[(3~{R},5~{R})-3-azanyl-6-(3-azanylpropylamino)-5-oxidanyl-hexanoyl]amino]-methyl-amino]ethanoic acid, 23S rRNA, ... | Authors: | Albers, S, Beckert, B, Matthies, M, Schuster, R, Riedner, M, Seuring, C, Sanyal, S, Torda, A, Wilson, N.D, Ignatova, Z. | Deposit date: | 2020-12-03 | Release date: | 2021-05-26 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Harnessing evolutionarily flexibility in tRNAs to maximize nonsense suppression activities Nat Commun, 2021
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8CVL
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![BU of 8cvl by Molmil](/molmil-images/mine/8cvl) | Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMTHSMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.30A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Syroegin, E.A, Aleksandrova, E.V, Polikanov, Y.S. | Deposit date: | 2022-05-18 | Release date: | 2022-10-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Insights into the ribosome function from the structures of non-arrested ribosome-nascent chain complexes. Nat.Chem., 15, 2023
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