8CRX

Cutibacterium acnes 70S ribosome with mRNA, P-site tRNA and Sarecycline bound

This is a non-PDB format compatible entry.

Summary for 8CRX

• Entry DOI: 10.2210/pdb8crx/pdb
• EMDB information: 26959
• Descriptor: RNA (1537-MER), 30S ribosomal protein S18, 30S ribosomal protein S20, ... (58 entities in total)
• Functional Keywords: ribosome, sarecycline, acne, antibiotic
• Biological source: Cutibacterium acnes; More
• Total number of polymer chains: 54
• Total formula weight: 2282924.41

Authors

Lomakin, I.B.,Devarkar, S.C.,Bunick, C.G. (deposition date: 2022-05-12, release date: 2023-03-22, Last modification date: 2023-04-19)

• Primary citation: Lomakin, I.B.,Devarkar, S.C.,Patel, S.,Grada, A.,Bunick, C.G.; Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism.; Nucleic Acids Res., 51:2915-2930, 2023; PubMed: 36864821; DOI: 10.1093/nar/gkad103

Experimental method

ELECTRON MICROSCOPY (2.78 Å)